{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T11:45:24Z","timestamp":1761306324862,"version":"build-2065373602"},"reference-count":16,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Subarachnoid hemorrhage (SAH) is a neurological emergency typically presenting with a sudden, severe headache. Focal neurological deficits are generally unilateral and correspond to the location of the aneurysm or hematoma. Bilateral lower limb paresis as an initial manifestation is extremely rare and may delay diagnosis. This report highlights a unique case and explores potential mechanisms underlying this atypical presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Case Description:<\/jats:title>\n                    <jats:p>\n                      A 62-year-old woman presented with acute bilateral leg weakness and headache. Imaging revealed diffuse SAH from a ruptured aneurysm at the right internal carotid\u2013posterior communicating artery junction, without mass effect . Magnetic resonance imaging revealed acute infarcts in the bilateral medial frontal lobes and the splenium of the corpus callosum, consistent with an infarction in the anterior cerebral artery territory. Angiography revealed no vasospasm, and spinal pathology was excluded. The aneurysm was successfully treated with coil embolization. The patient\u2019s leg strength gradually improved over the 1\n                      <jats:sup>st<\/jats:sup>\n                      month.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This case underscores the importance of including SAH in the differential diagnosis of acute paraparesis, even in the absence of classic signs. Bilateral infarcts may result from early microthrombosis or transient cerebral hypoperfusion following a sudden increase in intracranial pressure. Recognizing such mechanisms is essential for timely diagnosis and management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.25259\/sni_805_2025","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T11:37:56Z","timestamp":1761305876000},"page":"440","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bilateral lower-extremity paresis as an atypical presentation of subarachnoid hemorrhage: A case report"],"prefix":"10.25259","volume":"16","author":[{"given":"Saaya","family":"Maruyama","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, National Hospital Organization Mito Medical Center, Mito, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Hospital Organization Mito Medical Center, Mito, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniyuki","family":"Onuma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Hospital Organization Mito Medical Center, Mito, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Hospital Organization Mito Medical Center, Mito, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Hospital Organization Mito Medical Center, Mito, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"10.25259\/SNI_805_2025\/ref-1","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.07.009","article-title":"Focal neurological deficit at onset of aneurysmal subarachnoid hemorrhage: Frequency and causes","volume":"25","author":"Behrouz","year":"2016","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.25259\/SNI_805_2025\/ref-2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.7326\/0003-4819-146-1-200701020-00007","article-title":"Narrative review: Reversible cerebral vasoconstriction syndromes","volume":"146","author":"Calabrese","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.25259\/SNI_805_2025\/ref-3","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1161\/STROKEAHA.123.042799","article-title":"Sympathetic nervous hyperactivity impairs microcirculation leading to early brain injury after subarachnoid hemorrhage","volume":"54","author":"Demura","year":"2023","journal-title":"Stroke"},{"key":"10.25259\/SNI_805_2025\/ref-4","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3389\/fneur.2018.00292","article-title":"Neuroinflammation as a target for intervention in subarachnoid hemorrhage","volume":"9","author":"De Oliveira Manoel","year":"2018","journal-title":"Front Neurol"},{"key":"10.25259\/SNI_805_2025\/ref-5","doi-asserted-by":"crossref","first-page":"e5258","DOI":"10.1097\/MD.0000000000005258","article-title":"Mild encephalopathy with a reversible splenial lesion mimicking transient ischemic attack","volume":"95","author":"Dong","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.25259\/SNI_805_2025\/ref-6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.surneu.2004.12.019","article-title":"Paraparesis associated with ruptured anterior cerebral artery territory aneurysms","volume":"64","author":"Endo","year":"2005","journal-title":"Surg Neurol"},{"key":"10.25259\/SNI_805_2025\/ref-7","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/jcbfm.2011.154","article-title":"Experimental subarachnoid hemorrhage causes early and long-lasting microarterial constriction and microthrombosis: An invivo microscopy study","volume":"32","author":"Friedrich","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.25259\/SNI_805_2025\/ref-8","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1227\/00006123-198804000-00006","article-title":"The critical first minutes after subarachnoid hemorrhage","volume":"22","author":"Grote","year":"1988","journal-title":"Neurosurgery"},{"key":"10.25259\/SNI_805_2025\/ref-9","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0140-6736(07)60442-5","article-title":"Subarachnoid haemorrhage","volume":"369","author":"Holbrook","year":"2007","journal-title":"Lancet"},{"key":"10.25259\/SNI_805_2025\/ref-10","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.3390\/brainsci13071083","article-title":"Early brain injury and neuroprotective treatment after aneurysmal subarachnoid hemorrhage: A literature review","volume":"13","author":"Li","year":"2023","journal-title":"Brain Sci"},{"key":"10.25259\/SNI_805_2025\/ref-11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000507953","article-title":"Subarachnoid hemorrhage due to ruptured spinal artery aneurysm: A diagnostic challenge","volume":"12","author":"Nguyen","year":"2020","journal-title":"Case Rep Neurol"},{"key":"10.25259\/SNI_805_2025\/ref-12","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1179\/016164106X115008","article-title":"Molecular mechanisms of early brain injury after subarachnoid hemorrhage","volume":"28","author":"Ostrowski","year":"2006","journal-title":"Neurol Res"},{"key":"10.25259\/SNI_805_2025\/ref-13","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1089\/neu.2009.0924","article-title":"Acute hypoperfusion immediately after subarachnoid hemorrhage: A xenon contrast-enhanced CT study","volume":"26","author":"Schubert","year":"2009","journal-title":"J Neurotrauma"},{"key":"10.25259\/SNI_805_2025\/ref-14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pneurobio.2012.02.003","article-title":"The importance of early brain injury after subarachnoid hemorrhage","volume":"97","author":"Sehba","year":"2012","journal-title":"Prog Neurobiol"},{"key":"10.25259\/SNI_805_2025\/ref-15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00004647-200201000-00012","article-title":"Blood-brain barrier disruption in white matter lesions in a rat model of chronic cerebral hypoperfusion","volume":"22","author":"Ueno","year":"2002","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.25259\/SNI_805_2025\/ref-16","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1177\/0271678X211013595","article-title":"Acute micro-thrombosis after subarachnoid hemorrhage: A new therapeutic target?","volume":"41","author":"Ye","year":"2021","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/bilateral-lower-extremity-paresis-as-an-atypical-presentation-of-subarachnoid-hemorrhage-a-case-report","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/bilateral-lower-extremity-paresis-as-an-atypical-presentation-of-subarachnoid-hemorrhage-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T11:37:59Z","timestamp":1761305879000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/bilateral-lower-extremity-paresis-as-an-atypical-presentation-of-subarachnoid-hemorrhage-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":16,"alternative-id":["10.25259\/SNI_805_2025"],"URL":"https:\/\/doi.org\/10.25259\/sni_805_2025","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"type":"electronic","value":"2152-7806"},{"type":"print","value":"2229-5097"}],"subject":[],"published":{"date-parts":[[2025,10,24]]},"article-number":"440"}}