{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T20:18:54Z","timestamp":1768421934407,"version":"3.49.0"},"reference-count":15,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nOssifying fibromyxoid tumor (OFMT) is a rare musculoskeletal soft-tissue neoplasm of uncertain histogenesis most frequently occurring in the lower extremities. Conventionally, considered benign, these tumors are often managed by surgical resection followed by surveillance. However, malignant OFMTs with an increased propensity for local recurrence and distant metastasis have been recently identified, and the role of adjuvant therapy in these more aggressive cases is unclear.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nWe present, to the best of our knowledge, the first reported case of a primary, malignant, and intracranial OFMT. A 29-year-old female presented with recurrent headaches secondary to a large mass in her right frontal lobe. She underwent gross total resection of the brain mass with final pathology consistent with malignant OFMT demonstrating high-risk features including increased cellularity, grade, and mitotic activity. Due to these high-risk features, she received postoperative fractionated stereotactic radiation therapy (FSRT) to the resection cavity, and to the best of our knowledge, she represents the only known patient with OFMT to be treated with adjuvant FSRT. She tolerated the adjuvant treatment well with no acute or late toxicities and remains disease-free over 5 \u00bd years after resection.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nAdjuvant FSRT appears to be a safe and efficacious approach for managing this rare intracranial disease presentation. We review this patient\u2019s clinical course in the context of the literature to demonstrate the difficulties associated with accurate diagnosis of this rare tumor and the controversial role of adjuvant therapy in preventing disease recurrence in this patient population.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_827_2021","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T18:41:43Z","timestamp":1638297703000},"page":"588","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Malignant ossifying fibromyxoid tumor of the brain treated with post-operative fractionated stereotactic radiation therapy: A case report and literature review"],"prefix":"10.25259","volume":"12","author":[{"given":"Sasha","family":"Beyer","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, The Ohio State University, Columbus, Ohio,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil T.","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Emory University, Atlanta, Georgia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul Neal","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The Ohio State University, Columbus, Ohio,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The Ohio State University, Columbus, Ohio,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The Ohio State University, Columbus, Ohio,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kajal","family":"Madan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The Ohio State University, Columbus, Ohio,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The Ohio State University, Columbus, Ohio,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayeeta","family":"Ghose","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The Ohio State University, Columbus, Ohio,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dukagjin M.","family":"Blakaj","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The Ohio State University, Columbus, Ohio,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua D.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The Ohio State University, Columbus, Ohio,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Eltobgy","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, The Ohio State University, Columbus, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Otero","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, The Ohio State University, Columbus, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James B.","family":"Elder","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Ohio State University, Columbus, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raju R.","family":"Raval","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The Ohio State University, Columbus, Ohio,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"10.25259\/SNI_827_2021\/ref-1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.5858\/arpa.2014-0590-RS","article-title":"Ossifying fibromyxoid tumor: An update","volume":"140","author":"Bakiratharajan","year":"2016","journal-title":"Arch Pathol Lab Med"},{"key":"10.25259\/SNI_827_2021\/ref-2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cll.2017.06.005","article-title":"Soft tissue tumors of uncertain histogenesis: A review for dermatopathologists","volume":"37","author":"Buehler","year":"2017","journal-title":"Clin Lab Med"},{"key":"10.25259\/SNI_827_2021\/ref-3","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s00256-008-0562-0","article-title":"Ossifying fibromyxoid tumor invading the spine: A case report and review of the literature","volume":"37","author":"Cha","year":"2008","journal-title":"Skeletal Radiol"},{"key":"10.25259\/SNI_827_2021\/ref-4","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1097\/00000478-198910000-00001","article-title":"Ossifying fibromyxoid tumor of soft parts. 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