{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:57:50Z","timestamp":1793228270931,"version":"4.5.0"},"reference-count":10,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nTeratomas are a unique family of tumors derived from two or more of the three embryonic layers: endoderm, mesoderm, and ectoderm. Mature teratomas are comprised the most well-differentiated tissue types and may contain skin, hair, teeth, smooth muscle, respiratory tissues, etc. Infrequently, mature teratomas may be found within the central nervous system and, in exceedingly rare cases, may be occur within the spinal cord itself (i.e., intramedullary\/intradural).<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nA 78-year-old female presented with a subacute progressive lower extremity paraparesis. The MR revealed a cystic 81 \u00d7 30 \u00d7 25 mm intradural\/intramedullary spinal mass involving the distal conus with exophytic extension into the L1-L4 spinal canal. Following surgical intervention consisting of a L1-L4 laminectomy, the lesion was largely removed. Pathology of the mass confirmed a large mature teratoma containing a multilobulated cyst that intraoperatively compressed the conus and cauda equina. Immediately postoperatively, the patient significantly improved neurologically. However, on postoperative day 2, she acutely developed a change in mental status with the left gaze preference and hemiparesis. CT brain in the acute setting showed no evidence of causative pathology and subsequent MR brain was unremarkable. The patient\u2019s neurologic deficits progressively improved leading to eventual discharge.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nIntrathecal intramedullary\/extramedullary mature teratomas of the conus that results in subacute cauda equina syndromes are rare. The differential diagnosis for such lesions exophytic to the conus must include mature teratomas which, though rare, may be readily resected resulting in generally favorable outcomes.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_845_2021","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T09:07:16Z","timestamp":1641978436000},"page":"16","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Symptomatic mature teratoma of the lumbar spine: A case report"],"prefix":"10.25259","volume":"13","author":[{"given":"Coby","family":"Cunningham","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Drexel University College of Medicine, Philadelphia, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Flores","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Drexel University College of Medicine, Philadelphia, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Dabecco","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Allegheny General Hospital, Pittsburgh, Pennsylvania, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palgun","family":"Nisarga","sequence":"additional","affiliation":[{"name":"Department of Pathology, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Pathology, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Allegheny General Hospital, Pittsburgh, Pennsylvania, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"10.25259\/SNI_845_2021\/ref-1","first-page":"1719","article-title":"Primary central nervous system germ cell tumors: A review and update","volume":"6","author":"Fetcko","year":"2018","journal-title":"Med Res Arch"},{"key":"10.25259\/SNI_845_2021\/ref-2","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-323-44941-0.00018-7","article-title":"Germ cell tumors","volume-title":"Practical Surgical Neuropathology: A Diagnostic Approach","author":"Hattab","year":"2018","edition":"2nd ed"},{"key":"10.25259\/SNI_845_2021\/ref-3","doi-asserted-by":"crossref","first-page":"bcr2017223742","DOI":"10.1136\/bcr-2017-223742","article-title":"Acute regrowth and dissemination of a mature spinal cord teratoma after partial resection","volume":"2018","author":"Kawai","year":"2018","journal-title":"BMJ Case Rep"},{"key":"10.25259\/SNI_845_2021\/ref-4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/jnen\/61.3.215","article-title":"The WHO classification of tumors of the nervous system","volume":"61","author":"Kleihues","year":"2002","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.25259\/SNI_845_2021\/ref-5","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1148\/rg.2019180200","article-title":"Intradural extramedullary spinal neoplasms: Radiologic-pathologic correlation","volume":"39","author":"Koeller","year":"2019","journal-title":"Radiographics"},{"key":"10.25259\/SNI_845_2021\/ref-6","doi-asserted-by":"crossref","first-page":"844","DOI":"10.3171\/jns.1998.89.5.0844","article-title":"Intradural spinal teratoma: Evidence for a dysembryogenic origin. Report of four cases","volume":"89","author":"Koen","year":"1998","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_845_2021\/ref-7","first-page":"568062","article-title":"Malignant transformation in a mature teratoma with metastatic deposits in the omentum: A case report","volume":"2012","author":"Mandal","year":"2012","journal-title":"Case Rep Pathol"},{"key":"10.25259\/SNI_845_2021\/ref-8","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1148\/radiographics.21.2.g01mr09475","article-title":"Ovarian teratomas: Tumor types and imaging characteristics","volume":"21","author":"Outwater","year":"2001","journal-title":"Radiographics"},{"key":"10.25259\/SNI_845_2021\/ref-9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4103\/1793-5482.161181","article-title":"Spinal intradural extramedullary mature cystic teratoma in an adult: A rare tumor with review of literature","volume":"10","author":"Pandey","year":"2015","journal-title":"Asian J Neurosurg"},{"key":"10.25259\/SNI_845_2021\/ref-10","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3340\/jkns.2008.44.5.334","article-title":"Spinal intradural extramedullary mature cystic teratoma in an adult","volume":"44","author":"Sung","year":"2008","journal-title":"J Korean Neurosurg Soc"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/symptomatic-mature-teratoma-of-the-lumbar-spine-a-case-report\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/symptomatic-mature-teratoma-of-the-lumbar-spine-a-case-report\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T09:07:24Z","timestamp":1641978444000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/symptomatic-mature-teratoma-of-the-lumbar-spine-a-case-report\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,12]]},"references-count":10,"alternative-id":["10.25259\/SNI_845_2021"],"URL":"https:\/\/doi.org\/10.25259\/sni_845_2021","relation":{},"ISSN":["2152-7806"],"issn-type":[{"value":"2152-7806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,12]]},"article-number":"16"}}