{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:07:20Z","timestamp":1776413240826,"version":"3.51.2"},"reference-count":17,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Meningioma 1 (gene) (MN1)-altered astroblastoma is a rare central nervous system (CNS) lesion with variable and unpredictable morphology. Mainly affecting female children and young adults, it is believed to comprise only 0.45\u20132.8% of all neuroglial tumors.<\/jats:p>\n <\/jats:sec>\n \n Case Description:<\/jats:title>\n Herein, we present the case of a 21-year-old female who complained of diplopia and severe left-sided weakness for a month. Following a detailed molecular analysis, she was diagnosed with right frontoparietal MN1-altered astroblastoma, with MN1-BEN domain containing 2 (gene) fusion. She underwent surgical resection and fully recovered from her symptoms.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n This case report offers additional insights into cerebral MN1-astroblastoma, with a specific focus on its presentation in South Asian young adult patients. It emphasizes the importance of advanced molecular diagnostics for the correct classification of CNS tumors, to fully understand this rare but potentially aggressive pathology.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_85_2026","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T07:26:14Z","timestamp":1776410774000},"page":"227","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Frontoparietal astroblastoma with MN:1BEND2 fusion in a young woman: A case report"],"prefix":"10.25259","volume":"17","author":[{"given":"Amna Arshad","family":"Saroya","sequence":"first","affiliation":[{"name":"Medical College, Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zainab Haider","family":"Ejaz","sequence":"additional","affiliation":[{"name":"Medical College, Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usman","family":"Attique","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Section of Histopathology, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha Hassan","family":"Memon","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Section of Histopathology, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayan Sirat Maheen","family":"Anwar","sequence":"additional","affiliation":[{"name":"Department of Radiology, Section of Neuroradiology, Aga Khan University Hospital, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akbar Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Neurosurgery, Maroof International Hospital, Islamabad, 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