{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T06:02:30Z","timestamp":1673071350464},"reference-count":18,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Signet-ring cell carcinoma (SRCC) is a rare subtype of adenocarcinoma that frequently originates in the stomach. Uncommonly, this tumor can lead to brain metastases; an event rarely reported in the literature.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>A 76-year-old man with a history of cognitive impairment was diagnosed with two brain space-occupying lesions. A whole-body 18F-FDG PET\/computed tomography scan revealed a hypermetabolic lesion in a segment of the ileum corresponding to mural thickening and an ulcerated lesion detected on colonoscopy. A brain biopsy, using an immunohistochemistry protocol, showed signet-ring cells with a pattern that suggested an intestinal origin. The diagnosis of SRCC brain metastases with an ileal origin was made, and a treatment protocol was designed. However, the patient rapidly deteriorated, and passed away shortly afterward.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>To the best of our knowledge, this is the first case report of an ileal SRCC with brain metastases.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_870_2022","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T07:10:34Z","timestamp":1672989034000},"page":"6","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ileal signet-ring cell carcinoma with brain metastases: A case report"],"prefix":"10.25259","volume":"14","author":[{"given":"Jorge","family":"Cabrera-Montes","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Fuel-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Rey Juan Carlos University Hospital, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Lara-Almunia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Madrid, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"10.25259\/SNI_870_2022\/ref-1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.dld.2004.12.015","article-title":"Primary signet-ring cell carcinoma mimicking segmental Crohn\u2019s colitis","volume":"37","author":"Achneck","year":"2005","journal-title":"Dig Liver Dis"},{"key":"10.25259\/SNI_870_2022\/ref-2","first-page":"E89","article-title":"Leptomeningeal 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