{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:08:44Z","timestamp":1780646924788,"version":"3.54.1"},"reference-count":10,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nCastleman\u2019s disease (CD) is a rare lymphoproliferative disease of unknown origin which rarely affects the spine. Here, we present CD involving a lytic, destructive C3 lesion with extension into the spinal canal contributing to upper cervical cord compression. Notably, the lesion mimicked other primary bone lesions, metastatic tumors, and\/or lymphoma.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nA 52-year-old male presented with progressive quadriparesis (i.e. weakness, instability of gait) and loss of dexterity in both hands over 2 weeks. The MRI, X-ray, and CT scans revealed a destructive lytic lesion involving the C3 vertebral body (i.e. including both anterior and posterior elements). The patient underwent a C3 total and C4 partial laminectomy followed by a C2-C4\/5 instrumented fusion (i.e. included C2 pedicle screws\/laminar screws, and C4\/C5 lateral mass fixation). Histopathology showed a lymphoproliferative disorder with follicles of different sizes, central abnormal germinal structures, and a Mantle zone (i.e. expanded germinal centre with concentric layering with an \u201conionskin\u201d appearance). These findings were all consistent with the diagnosis of CD (i.e. hyaline-vascular type).<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nCD, a rare lymphoproliferative disease of unknown origin rarely affects the spine. Here, we presented a 52-year-old male with a C3 lytic lesion resulting in C3\/4 cord compression that favorably responded to a C3\/4 laminectomy with posterior instrumented fusion.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_909_2021","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T10:29:20Z","timestamp":1636453760000},"page":"552","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Subaxial cervical Castleman\u2019s disease: A rare cause of myelopathy"],"prefix":"10.25259","volume":"12","author":[{"given":"Abhinandan Reddy","family":"Mallepally","sequence":"first","affiliation":[{"name":"Department of Spine Services, Indian Spinal Injuries Centre, New Delhi,"},{"name":"Department of Intern, Seth GSMC and KEM Hospital, Mumbai, Maharashtra, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrit","family":"Gantaguru","sequence":"additional","affiliation":[{"name":"Department of Spine Services, Indian Spinal Injuries Centre, New Delhi,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandan","family":"Marathe","sequence":"additional","affiliation":[{"name":"Department of Spine Services, Indian Spinal Injuries Centre, New Delhi,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarush","family":"Rustagi","sequence":"additional","affiliation":[{"name":"Department of Spine Services, Indian Spinal Injuries Centre, New Delhi,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alhad","family":"Mulkalwar","sequence":"additional","affiliation":[{"name":"Department of Intern, Seth GSMC and KEM Hospital, Mumbai, Maharashtra, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalidutta","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Spine Services, Indian Spinal Injuries Centre, New Delhi,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"10.25259\/SNI_909_2021\/ref-1","first-page":"122","article-title":"Successful treatment of pure red cell aplasia complicated by multicentric Castleman disease with prednisolone","volume":"61","author":"Arai","year":"2020","journal-title":"Rinsho Ketsueki"},{"key":"10.25259\/SNI_909_2021\/ref-2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/1097-0142(195607\/08)9:4<822::AID-CNCR2820090430>3.0.CO;2-4","article-title":"Localized mediastinal lymph-node hyperplasia resembling thymoma","volume":"9","author":"Castleman","year":"1956","journal-title":"Cancer"},{"key":"10.25259\/SNI_909_2021\/ref-3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3171\/spi.2007.6.5.455","article-title":"Castleman disease of the spine mimicking a nerve sheath tumor. Case report","volume":"6","author":"Finn","year":"2007","journal-title":"J Neurosurg Spine"},{"key":"10.25259\/SNI_909_2021\/ref-4","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1227\/00006123-198904000-00021","article-title":"Castleman\u2019s disease manifesting in the central nervous system: Case report with immunological studies","volume":"24","author":"Gianaris","year":"1989","journal-title":"Neurosurgery"},{"key":"10.25259\/SNI_909_2021\/ref-5","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3816\/CLM.2009.n.050","article-title":"Multicentric hyaline vascular type Castleman disease presenting as an epidural mass causing paraplegia: A case report","volume":"9","author":"Gupta","year":"2009","journal-title":"Clin Lymphoma Myeloma"},{"key":"10.25259\/SNI_909_2021\/ref-6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.clineuro.2011.10.033","article-title":"Castleman disease of the sacral spine","volume":"114","author":"McMillan","year":"2012","journal-title":"Clin Neurol Neurosurg"},{"key":"10.25259\/SNI_909_2021\/ref-7","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3904\/kjim.2019.330","article-title":"The clinical, laboratory, and radiologic improvement due to siltuximab treatment in idiopathic multicentric Castleman\u2019s disease","volume":"36","author":"Min","year":"2020","journal-title":"Korean J Intern Med"},{"key":"10.25259\/SNI_909_2021\/ref-8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3171\/jns.1988.69.2.0283","article-title":"Castleman\u2019s disease of the leptomeninges, Report of three cases","volume":"69","author":"Severson","year":"1988","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_909_2021\/ref-9","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1182\/blood-2018-07-862334","article-title":"International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease","volume":"132","author":"van Rhee","year":"2018","journal-title":"Blood"},{"key":"10.25259\/SNI_909_2021\/ref-10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/1097-0142(197908)44:2<457::AID-CNCR2820440212>3.0.CO;2-4","article-title":"Remission of giant lymph node hyperplasia with anemia after radiotherapy","volume":"44","author":"Weisenburger","year":"1979","journal-title":"Cancer"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/subaxial-cervical-castlemans-disease-a-rare-cause-of-myelopathy\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/subaxial-cervical-castlemans-disease-a-rare-cause-of-myelopathy\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T10:29:26Z","timestamp":1636453766000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/subaxial-cervical-castlemans-disease-a-rare-cause-of-myelopathy\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,8]]},"references-count":10,"alternative-id":["10.25259\/SNI_909_2021"],"URL":"https:\/\/doi.org\/10.25259\/sni_909_2021","relation":{},"ISSN":["2152-7806"],"issn-type":[{"value":"2152-7806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,8]]},"article-number":"552"}}