{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T07:29:26Z","timestamp":1781162966224,"version":"3.54.1"},"reference-count":7,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nThe aim was to study functional recovery in experimental animals (rabbits) with transected spinal cords treated with a combination of photo-cross-linked chitosan in a homogeneous mixture with polyethylene glycol (PEG-chitosan).<\/jats:p>\n<\/jats:sec>\n\nMethods: <\/jats:title>\n20 rabbits (n<\/jats:italic> = 10 experimental and n<\/jats:italic> = 10 controls) were submitted to complete spinal cord transection at T9. The experimental group received an intraoperative injection of PEG-chitosan. Neurological recovery was assessed using the modified Basso, Beattie, and Bresnahan scale.<\/jats:p>\n<\/jats:sec>\n\nResults: <\/jats:title>\nIn the experimental group, partial recovery of movements, sensory function, and sphincter control were all observed by postoperative day 30. Paraplegia and anesthesia persisted in the control group; 4 controls died versus none in the test group.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nPEG-chitosan is a candidate for neurological restoration after spinal paralysis.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_927_2023","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T05:57:36Z","timestamp":1702533456000},"page":"423","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chitosan\/PEG-mediated spinal cord fusion after complete dorsal transection in rabbits \u2013 functional results at 30 days"],"prefix":"10.25259","volume":"14","author":[{"given":"Michael","family":"Lebenstein-Gumovski","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, Stavropol State Medical University, Stavropol, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanzila","family":"Rasueva","sequence":"additional","affiliation":[{"name":"Clinic of Neurosurgery, N. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Zharchenko","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Stavropol State Medical University, Stavropol, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bashahanov","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Stavropol State Medical University, Stavropol, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry A.","family":"Kovalev","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Stavropol Research Institute for Plague Control, Stavropol, Russian Federation."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Zhirov","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Stavropol Research Institute for Plague Control, Stavropol, Russian Federation."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Shatokhin","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Stavropol State Medical University, Stavropol, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Grin","sequence":"additional","affiliation":[{"name":"Clinic of Neurosurgery, N. V. Sklifosovsky Research Institute for Emergency Medicine, Moscow Healthcare Department, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"10.25259\/SNI_927_2023\/ref-1","article-title":"The technology of head transplantation","author":"Canavero","year":"2020"},{"key":"10.25259\/SNI_927_2023\/ref-2","first-page":"83","article-title":"Spinal cord fusion in rodents and dogs","volume-title":"The technology of head transplantation","author":"Kim","year":"2020"},{"key":"10.25259\/SNI_927_2023\/ref-3","article-title":"Method for restoring the functions of the spinal cord after transection thereof, using PEG-chitosan conjugate, Russian Federation patent RU 2782119 C1, registration \u2116 2021120198","author":"Lebenstein-Gumovski","year":"2021"},{"key":"10.25259\/SNI_927_2023\/ref-4","article-title":"Method of treatment of spinal cord injury with restoration of its functions with PEG-chitosan conjugate \u00abNEURO-PEG\u00bb, Russian Federation patent RU 2801469 C1, registration No 2022128384","author":"Lebenstein-Gumovski","year":"2022"},{"key":"10.25259\/SNI_927_2023\/ref-5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.17116\/neiro20238705136","article-title":"Recovery of spinal cord functions after experimental complete crossection under the effect of chitosan polymeric compounds","volume":"87","author":"Lebenstein-Gumovski","year":"2023","journal-title":"Zh Vopr Neirokhir Im N N Burdenko"},{"key":"10.25259\/SNI_927_2023\/ref-6","first-page":"37","article-title":"Characterization of morphological and functional changes in the spinal cord after its section, under the influence of a hydrogel based on a modification of chitosan","volume":"3","author":"Lebenstein-Gumovski","year":"2021","journal-title":"Volgogr Nauchno Med Zh"},{"key":"10.25259\/SNI_927_2023\/ref-7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.25259\/SNI-19-2019","article-title":"Bridging the gap: Spinal cord fusion as a treatment of chronic spinal cord injury","volume":"10","author":"Ren","year":"2019","journal-title":"Surg Neurol Int"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/chitosan-peg-mediated-spinal-cord-fusion-after-complete-dorsal-transection-in-rabbits-functional-results-at-30-days\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/chitosan-peg-mediated-spinal-cord-fusion-after-complete-dorsal-transection-in-rabbits-functional-results-at-30-days\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T05:57:39Z","timestamp":1702533459000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/chitosan-peg-mediated-spinal-cord-fusion-after-complete-dorsal-transection-in-rabbits-functional-results-at-30-days\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":7,"alternative-id":["10.25259\/SNI_927_2023"],"URL":"https:\/\/doi.org\/10.25259\/sni_927_2023","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12,13]]},"article-number":"423"}}