{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:05:28Z","timestamp":1790226328096,"version":"4.1.0"},"reference-count":44,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Malignant peripheral nerve sheath tumors (MPNSTs) are rare malignant soft-tissue sarcomas arising from peripheral nerves. Little data exist regarding MPNST originating intracranially. Here, we present a 7<jats:sup>th<\/jats:sup>\/8<jats:sup>th<\/jats:sup> nerve complex MPNST, discuss the treatment strategy and patient outcome, and provide a comprehensive review of existing literature.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Methods: <\/jats:title>\n<jats:p>Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, PubMed and crossed references were queried, yielding 37 publications from 1952 to the present. Fifty-three cases of primary intracranial and extra-axial MPNST were identified.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results: <\/jats:title>\n<jats:p>We additionally report a 40-year-old female presented with acute onset dizziness and subsequent hearing loss with associated right-sided facial numbness. Magnetic resonance imaging revealed a 0.5 cm \u00d7 1.7 cm enhancing lesion within the right internal auditory canal extending into the cerebellopontine angle. The patient was initially treated with retro sigmoid craniotomy for tumor resection followed by a trans labyrinth approach for residual tumor resection. She completed adjuvant fractionated radiation therapy and underwent facial nerve transfer to restore complete hemifacial paralysis. The most common cranial nerves involved were V and VIII (43.4% each), with 66% of patients male and 34% female. The average age was 43.4 \u00b1 17.4 years. The mean survival time for reported non-survivors after tissue diagnosis was 15 \u00b1 4 months. Two-year survival for patients receiving gross total resection was 33.3% versus 22.8% with subtotal resection.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>MPNSTs comprise a group of highly aggressive neoplasms that rarely arise intracranially. Gross total surgical resection should be pursued when feasible.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_931_2023","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T10:13:23Z","timestamp":1711102403000},"page":"101","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intracranial malignant peripheral nerve sheath tumor: A case report and comprehensive literature review"],"prefix":"10.25259","volume":"15","author":[{"given":"Brandon Michael","family":"Wilkinson","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, State University of New York Upstate Medical University (SUNY), Syracuse, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, State University of New York Upstate Medical University (SUNY), Syracuse, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Davila","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, State University of New York Upstate Medical University (SUNY), Syracuse, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Nicholas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, White Plains Hospital, White Plains, New York, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Babu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, State University of New York Upstate Medical University (SUNY), Syracuse, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"10.25259\/SNI_931_2023\/ref-1","doi-asserted-by":"crossref","first-page":"E205","DOI":"10.1093\/ons\/opz014","article-title":"Multidisciplinary approach to malignant peripheral nerve sheath tumor of the trigeminal nerve: 2-dimensional operative video","volume":"17","author":"Abou-Al-Shaar","year":"2019","journal-title":"Oper Neurosurg (Hagerstown)"},{"key":"10.25259\/SNI_931_2023\/ref-2","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s007010050475","article-title":"Primary intracranial malignant schwannoma of trigeminal nerve. 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Case report","volume":"41","author":"Tegos","year":"1997","journal-title":"J Neurosurg Sci"},{"key":"10.25259\/SNI_931_2023\/ref-37","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2176\/nmc.44.38","article-title":"Malignant peripheral nerve sheath tumor in the anterior skull base associated with neurofibromatosis type 1--case report","volume":"44","author":"Ueda","year":"2004","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10.25259\/SNI_931_2023\/ref-38","doi-asserted-by":"crossref","first-page":"654.e1","DOI":"10.1016\/j.wneu.2012.08.007","article-title":"Malignant peripheral nerve sheath tumor of the abducens nerve and a review of the literature","volume":"80","author":"Voorhies","year":"2013","journal-title":"World Neurosurg"},{"key":"10.25259\/SNI_931_2023\/ref-39","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/1097-0142(19930215)71:4<1247::AID-CNCR2820710413>3.0.CO;2-S","article-title":"Malignant peripheral nerve sheath tumors. 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