{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T06:02:30Z","timestamp":1673071350386},"reference-count":12,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackgound: <\/jats:title>\nPituitary apoplexy is associated with stroke, head injury, and brain tumors. Still, its presentation due to the ruptured aneurysm is rare and its presentation with akinetic mutism has not been reported.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nThe patient in the present study is 21-year-old female who presented in our emergency department in an altered sensorium with Glasgow comma score (GCS) E2V1M1. She was intubated and resuscitated. Routine blood investigations, lipid profile, and hormonal studies were normal. Initial noncontrast computed tomography (NCCT) head revealed subarachnoid hemorrhage in the interhemispheric fissure and evidence of bleeding in the pituitary gland. Magnetic resonance imaging (MRI) brain was soon done, which showed an infarct and hemorrhage in the pituitary gland; there was an evidence of an infarct in the bilateral medial frontal gyrus, basal ganglia, and supplementary motor area. MR arteriography revealed an aneurysm at the left A1-anterior communicating artery (Acom) junction directed superomedially with diffuse spasm in a bilateral anterior cerebral artery. Pterional craniotomy was done with clipping of the aneurysm and evacuation of blood clots from the interhemispheric fissure and pituitary gland. Histopathology features suggestive of the non-functioning pituitary tumor with interspersed hemorrhagic necrosis. Intraarterial vasodilation with microcatheter injection was given, but vasospasm did not improve. Postoperatively, Levodopa was started. She used to track objects in front of her eye and started nodding her head in \u201cyes and no fashion,\u201d with power in limbs improved to 3\/5 at 6 months of follow-up.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nPituitary apoplexy with ruptured A1-Acom junction aneurysm with nonfunctioning pituitary macroadenoma is rare, and its presentation with akinetic mutism has not been reported. As there is scarce literature suggesting an association between pituitary apoplexy and ruptured aneurysm, it is challenging to comment regarding its pathogenesis. Although akinetic mutism generally has a poor prognosis, it may respond to Levodopa with a better outcome.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_942_2022","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T07:30:32Z","timestamp":1672990232000},"page":"4","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management dilemma in a rare case of pituitary apoplexy with akinetic mutism in the setting of ruptured junctional brain aneurysm: A case report and literature review"],"prefix":"10.25259","volume":"14","author":[{"given":"Vikas Chandra","family":"Jha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Shahnawaz","family":"Alam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek Sharan","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"10.25259\/SNI_942_2022\/ref-1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neubiorev.2020.02.006","article-title":"On the pathophysiology and treatment of akinetic mutism","volume":"112","author":"Arnts","year":"2020","journal-title":"Neurosci Biobehav Rev"},{"key":"10.25259\/SNI_942_2022\/ref-2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/02688690410001732698","article-title":"Subarachnoid hemorrhage and akinetic mutism","volume":"18","author":"Choudhari","year":"2004","journal-title":"Br J Neurosurg"},{"key":"10.25259\/SNI_942_2022\/ref-3","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s004150070161","article-title":"Akinetic mutism from frontal lobe damage responding to Levodopa","volume":"247","author":"Combarros","year":"2000","journal-title":"J Neurol"},{"key":"10.25259\/SNI_942_2022\/ref-4","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0967-5868(02)00323-5","article-title":"Coexistence of aneurysmal subarachnoid hemorrhage and pituitary apoplexy: Case report and review of the literature","volume":"10","author":"Laidlaw","year":"2003","journal-title":"J Clin Neurosci"},{"key":"10.25259\/SNI_942_2022\/ref-5","first-page":"273","article-title":"Akinetic mutism caused by subarachnoid hemorrhage. 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