{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T10:40:20Z","timestamp":1738924820731,"version":"3.37.0"},"reference-count":18,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nOptic nerve sheath hemangiomas (ONSHs) are rare vascular tumors from the blood vessels surrounding the optic nerve, accounting for <1% of optic tumors and 0.5% of vascular malformations. Although benign, their location near the optic nerve poses a risk of significant nerve damage and vision loss. Symptoms often include visual disturbances, eye pain, and strabismus, making it difficult to make a diagnosis. Advances in imaging, especially magnetic resonance imaging (MRI), have improved early detection and diagnosis. In addition, insights into the molecular mechanisms, including endothelial signaling and angiogenesis, have facilitated the development of more effective treatments, such as targeted therapies and minimally invasive surgical options.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nWe present the case of a 57-year-old woman who experienced progressive left-eye swelling, increased tearing, and declining visual acuity. Imaging studies, including MRI and computed tomography scans, revealed a left intraconal mass suggestive of ONSH. A transcranial-modified orbitofrontal approach was employed for tumor resection due to its proximity to vital structures. Postoperative histopathology confirmed hemangioma. At 1-year follow-up, the patient exhibited significant improvement in visual function and resolution of orbital swelling.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nThis case highlights the critical role of surgical intervention in managing ONSHs that threaten visual function and cause mass effects. The transcranial-modified orbitofrontal approach proved effective in providing optimal access for safe tumor resection and improving visual outcomes. Integrating advanced imaging techniques and intraoperative monitoring contributes significantly to enhancing prognosis in ONSH cases.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_979_2024","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T09:32:33Z","timestamp":1738920753000},"page":"35","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modified orbitofrontal approach for optic nerve sheath hemangioma: Illustrative case and literature review"],"prefix":"10.25259","volume":"16","author":[{"given":"Jos\u00e9 de Jes\u00fas","family":"Guti\u00e9rrez-Ba\u00f1os","sequence":"first","affiliation":[{"name":"st,"},{"name":"Department of Endovascular Neurosurgery, Stroke Team Mexico, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Castillo-Rangel","sequence":"additional","affiliation":[{"name":"st,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio Ivan","family":"Rodriguez-Pereira","sequence":"additional","affiliation":[{"name":"Department of Endovascular Neurosurgery, Stroke Team Mexico, Mexico City, Mexico"},{"name":"st,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Ordo\u00f1ez Granja","sequence":"additional","affiliation":[{"name":"st,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Oswaldo","family":"D\u00e1vila-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"st,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jecs\u00e1n","family":"Tovar-Fuentes","sequence":"additional","affiliation":[{"name":"Stroke Team Mexico, American Association of Neurological Surgeons Student Chapter, Autonomous University of the State of Hidalgo, Hidalgo, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alondra Sarai","family":"Tovar-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Stroke Team Mexico, American Association of Neurological Surgeons Student Chapter, Autonomous University of the State of Hidalgo, Hidalgo, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Alberto","family":"Hern\u00e1ndez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Stroke Team Mexico, American Association of Neurological Surgeons Student Chapter, Autonomous University of the State of Hidalgo, Hidalgo, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"10.25259\/SNI_979_2024\/ref-1","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in signaling and disease: Beyond discovery and development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell"},{"key":"10.25259\/SNI_979_2024\/ref-2","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1097\/IAE.0000000000002191","article-title":"Multimodal imaging of optic nerve head capillary hemangioma","volume":"38","author":"Cennamo","year":"2018","journal-title":"Retina"},{"key":"10.25259\/SNI_979_2024\/ref-3","doi-asserted-by":"crossref","first-page":"F1000","DOI":"10.12688\/f1000research.20152.1","article-title":"Hemangioma: Recent advances","volume":"8","author":"DeHart","year":"2019","journal-title":"F1000Res"},{"issue":"S1","key":"10.25259\/SNI_979_2024\/ref-4","first-page":"S43","article-title":"Interdisziplin\u00e4re therapie der erkrankungen der orbita [Interdisciplinary management of orbital diseases]","volume":"103","author":"Eckstein","year":"2024","journal-title":"Laryngorhinootologie"},{"key":"10.25259\/SNI_979_2024\/ref-5","article-title":"International Society for the Study of Vascular Anomalies","author":"ISSVA classification of vascular tumors and vascular malformations","year":"2018"},{"key":"10.25259\/SNI_979_2024\/ref-6","doi-asserted-by":"crossref","first-page":"1446046","DOI":"10.3389\/fmed.2024.1446046","article-title":"Targeted therapies for vascular malformations","volume":"11","author":"Kane","year":"2024","journal-title":"Front Med"},{"key":"10.25259\/SNI_979_2024\/ref-7","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.jfo.2021.02.012","article-title":"A holy ball for the optic nerve head: Aesthetic capillary hemangioma","volume":"44","author":"Kaspi","year":"2021","journal-title":"J Fran\u00e7 Ophtalmol"},{"key":"10.25259\/SNI_979_2024\/ref-8","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.3390\/ijms23042358","article-title":"ISSVA classification of vascular anomalies and molecular biology","volume":"23","author":"Kunimoto","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.25259\/SNI_979_2024\/ref-9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1023\/A:1006416003964","article-title":"VEGF in brain tumors","volume":"50","author":"Machein","year":"2000","journal-title":"J NeuroOncol"},{"key":"10.25259\/SNI_979_2024\/ref-10","doi-asserted-by":"crossref","first-page":"15585","DOI":"10.3390\/ijms232415585","article-title":"The VEGF\/VEGFR axis revisited: Implications for cancer therapy","volume":"23","author":"Mabeta","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.25259\/SNI_979_2024\/ref-11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/00002341-199905000-00005","article-title":"Removal of orbital apex hemangioma using new transorbital craniotomy through suprabrow approach","volume":"15","author":"Maus","year":"1999","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"10.25259\/SNI_979_2024\/ref-12","first-page":"71","article-title":"The 5th edition of the World Health Organization classification of tumours of the eye and orbit","volume-title":"Ocular Oncol Pathol","volume":"9","author":"Milman","year":"2023"},{"key":"10.25259\/SNI_979_2024\/ref-13","first-page":"510","article-title":"Klinische und neuroradiologische diagnostik bei orbitatumoren [Clinical and neuroradiological diagnostics of orbital tumors]","volume":"108","author":"Poloschek","year":"2011","journal-title":"Ophthalmol"},{"key":"10.25259\/SNI_979_2024\/ref-14","doi-asserted-by":"crossref","first-page":"122","DOI":"10.25259\/SNI_1016_2023","article-title":"Surgical treatment of orbital tumors in a single center: Analysis and results","volume":"15","author":"Reyes-Soto","year":"2024","journal-title":"Surg Neurol Int"},{"key":"10.25259\/SNI_979_2024\/ref-15","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.oret.2020.04.004","article-title":"Swept source OCT angiography of optic nerve head retinal capillary hemangioma","volume":"4","author":"Statler","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"10.25259\/SNI_979_2024\/ref-16","doi-asserted-by":"crossref","first-page":"66","DOI":"10.17116\/oftalma202213802166","article-title":"Gemangiomy diska zritel\u2019nogo nerva [Hemangiomas of the optic nerve head]","volume":"138","author":"Stoyukhina","year":"2022","journal-title":"Vest Oftalmol"},{"key":"10.25259\/SNI_979_2024\/ref-17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/his.14458","article-title":"The genetics of vascular tumours: An update","volume":"80","author":"Torrence","year":"2022","journal-title":"Histopathology"},{"key":"10.25259\/SNI_979_2024\/ref-18","doi-asserted-by":"crossref","first-page":"117181","DOI":"10.1016\/j.biopha.2024.117181","article-title":"Insights into the mechanisms of angiogenesis in infantile hemangioma","volume":"178","author":"Xiang","year":"2024","journal-title":"Biomed Pharmacother"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/modified-orbitofrontal-approach-for-optic-nerve-sheath-hemangioma-illustrative-case-and-literature-review\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/modified-orbitofrontal-approach-for-optic-nerve-sheath-hemangioma-illustrative-case-and-literature-review\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T09:32:43Z","timestamp":1738920763000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/modified-orbitofrontal-approach-for-optic-nerve-sheath-hemangioma-illustrative-case-and-literature-review\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,7]]},"references-count":18,"alternative-id":["10.25259\/SNI_979_2024"],"URL":"https:\/\/doi.org\/10.25259\/sni_979_2024","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,7]]},"article-number":"35"}}