{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T08:55:38Z","timestamp":1753520138851},"reference-count":17,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nMultiple anterior cervical diskectomy\/fusion (ACDF) techniques now use a variety of Polyehteretherketone (PEEK) cages; stand-alone (SA) and zero-profile (ZP) with\/without screws, cages filled with demineralized bone matrix\/autograft, and cages coated with hydroxyapatite or titanium. We compared the safety\/ efficacy between different PEEK ACDF cage constructs in 17 studies, and in some cases, additionally contrasted results with \u201croutine\u201d ACDF (i.e. series\/historical data performed with combinations of iliac autograft\/allograft and plates).<\/jats:p>\n<\/jats:sec>\n\nMethods: <\/jats:title>\nWe focused on the clinical outcomes, fusion rates, postoperative radiographic changes\/lordosis\/ subsidence, and\/or reoperation rates for various PEEK ACDF constructs vs. \u201croutine\u201d ACDF.<\/jats:p>\n<\/jats:sec>\n\nResults: <\/jats:title>\nOne to 3 and 4-level PEEK ACDF cages demonstrated high fusion rates, few cage failures, and low reoperation rates. Subsidence for PEEK ACDF cages did not reduce fusion rates or diminish the quality of postoperative outcomes. Further, titanium-coated (T-C) PEEK cages lowered fusion rates in one study (i.e. 44.1% fusions vs. 88.2% for routine PEEK ACDF) while ACDF PEEK cages coated with hydroxyapatite (HA) showed only a \u201ctrend\u201d toward enhanced arthrodesis.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nOne to 3-4 multilevel ACDF PEEK cage constructs demonstrated comparable safety\/efficacy when compared with each other, or in select cases, with \u201croutine\u201d ACDF (i.e. using autograft\/allograft and plates).<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_992_2022","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T06:31:15Z","timestamp":1669357875000},"page":"556","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Review of anterior cervical diskectomy\/fusion (ACDF) using different polyetheretherketone (PEEK) cages"],"prefix":"10.25259","volume":"13","author":[{"given":"Nancy E.","family":"Epstein","sequence":"first","affiliation":[{"name":"Clinical Professor of Neurosurgery, School of Medicine, State University of NY at Stony Brook, and Editor-in-Chief Surgical Neurology International NY and \u2105 Dr. Marc Agulnick 1122 Frankllin Avenue Suite 106, Garden City, NY 11530, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A.","family":"Agulnick","sequence":"additional","affiliation":[{"name":"Assistant Clinical Professor of Orthopedics, NYU Langone Hospital, Long Island, NY, USA. 1122 Franklin Avenue Suite 106 Garden City, NY 11530, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"10.25259\/SNI_992_2022\/ref-1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/jcvjs.JCVJS_62_20","article-title":"Stand-alone polyetheretherketone cages for anterior cervical discectomy and fusion for successive four-level degenerative disc disease without plate fixation","volume":"11","author":"Ashour","year":"2020","journal-title":"J Craniovertebr Junction Spine"},{"key":"10.25259\/SNI_992_2022\/ref-2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02688697.2021.2005772","article-title":"A pragmatic single centre retrospective comparative review of complication profile between PEEK cages and zero-P cage screw constructs","author":"Balakumar","year":"2021","journal-title":"Br J Neurosurg"},{"key":"10.25259\/SNI_992_2022\/ref-3","first-page":"e17457","article-title":"Effectiveness of a fully impregnated hydroxyapatite polyetheretherketone cage on fusion in anterior cervical spine surgery","volume":"13","author":"Chin","year":"2021","journal-title":"Cureus"},{"key":"10.25259\/SNI_992_2022\/ref-4","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1097\/00006123-200212000-00003","article-title":"Preliminary experience using a polyetheretherketone (PEEK) cage in the treatment of cervical disc 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spondylotic myelopathy: Results from a minimum 2-year follow-up","volume":"13","author":"Ng","year":"2019","journal-title":"Asian Spine J"},{"key":"10.25259\/SNI_992_2022\/ref-11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jocn.2016.01.042","article-title":"Subsidence after single-level anterior cervical fusion with a stand-alone cage","volume":"33","author":"Park","year":"2016","journal-title":"J Clin Neurosci"},{"key":"10.25259\/SNI_992_2022\/ref-12","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.jocn.2012.10.028","article-title":"Anterior cervical discectomy plus intervertebral polyetheretherketone cage fusion over three and four levels without plating is safe and effective long-term","volume":"20","author":"Pereira","year":"2013","journal-title":"J Clin Neurosci"},{"key":"10.25259\/SNI_992_2022\/ref-13","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00701-015-2630-2","article-title":"Clinical and radiological outcome after anterior cervical discectomy and fusion with stand-alone empty polyetheretherketone (PEEK) cages","volume":"158","author":"Shiban","year":"2016","journal-title":"Acta Neurochir (Wien)"},{"key":"10.25259\/SNI_992_2022\/ref-14","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00701-018-3495-y","article-title":"No correlation between radiological and clinical outcome 1 year following cervical arthrodesis","volume":"160","author":"Shiban","year":"2018","journal-title":"Acta Neurochir (Wien)"},{"key":"10.25259\/SNI_992_2022\/ref-15","doi-asserted-by":"crossref","first-page":"268","DOI":"10.14740\/jocmr3326w","article-title":"Correlation of clinical and radiological outcome after anterior cervical discectomy and fusion with a polyetheretherketone cage","volume":"10","author":"Spanos","year":"2018","journal-title":"J Clin Med 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