{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:56:39Z","timestamp":1767833799592,"version":"3.49.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"DOI":"10.2527\/jas.2012-5208","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T02:34:26Z","timestamp":1362537266000},"page":"2405-2413","source":"Crossref","is-referenced-by-count":10,"title":["Immune modulation effect of porcine placenta extracts in weaned the pig1"],"prefix":"10.1093","volume":"91","author":[{"given":"K. H.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Animal and Food Bioscience, College of Natural Science, Konkuk University, Chung-ju 380-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Bioscience, College of Natural Science, Konkuk University, Chung-ju 380-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. G.","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Animal Biotechnology, College of Animal Biotechnology, Konkuk University, Seoul 143-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Biotechnology, College of Animal Biotechnology, Konkuk University, Seoul 143-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. S.","family":"Lim","sequence":"additional","affiliation":[{"name":"Korea Feed Ltd., Busan 617-050, Chungbuk National University, Choung-ju 361-763, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Bioscience, College of Natural Science, Konkuk University, Chung-ju 380-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science, College of Agriculture, Chungbuk National University, Choung-ju 361-763, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, College of Life Science, CHA University, Seongnam 463-836, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Konkuk University, Chung-ju 380-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. S.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, School of Medicine, Konkuk University, Chung-ju 380-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H.","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Bioscience, College of Natural Science, Konkuk University, Chung-ju 380-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Bioscience, College of Natural Science, Konkuk University, Chung-ju 380-701, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20180302052415_bib1","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1128\/AAC.45.7.2054-2059.2001","article-title":"Effect of abolishment of the use of antimicrobial agents for growth promotion on occurrence of antimicrobial resistance in fecal enterococci from food animals in Denmark","volume":"45","author":"Aarestrup","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"key\n\t\t\t\t20180302052415_bib2","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000222673","article-title":"BCG priming of dendritic cells enhances T regulatory and Th1 function and suppresses allergen-induced Th2 function in vitro and in vivo","volume":"150","author":"Ahrens","year":"2009","journal-title":"Int. Arch. Allergy Immunol."},{"key":"key\n\t\t\t\t20180302052415_bib3","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S1473-3099(01)00145-1","article-title":"Vancomycin-resistant enterococci: Why are they here, and where do they come from?","volume":"1","author":"Bonten","year":"2001","journal-title":"Lancet Infect. Dis."},{"key":"key\n\t\t\t\t20180302052415_bib4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.intimp.2005.07.018","article-title":"In vitro induction of nitric oxide by mouse peritoneal macrophages treated with human placental extract","volume":"6","author":"Chakraborty","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"key\n\t\t\t\t20180302052415_bib5","doi-asserted-by":"crossref","first-page":"460S","DOI":"10.1093\/ajcn\/66.2.460S","article-title":"Nutrition and the immune system: An introduction","volume":"66","author":"Chandra","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"key\n\t\t\t\t20180302052415_bib6","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.cell.2010.09.039","article-title":"Microbial stimulation fully differentiates monocytes to DC-SIGN\/CD209+ dendritic cells for immune T cell areas","volume":"143","author":"Cheong","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180302052415_bib7","first-page":"401","article-title":"Antimicrobial and promicrobial agents","volume-title":"Factors that influence swine nutrition.","author":"Cromwell","year":"2001","edition":"2nd ed."},{"key":"key\n\t\t\t\t20180302052415_bib8","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0731-7085(03)00654-X","article-title":"Spectroscopic and chromatographic evidences of NADPH in human placental extract used as wound healer","volume":"34","author":"Datta","year":"2004","journal-title":"J. Pharm. Biomed. Anal."},{"key":"key\n\t\t\t\t20180302052415_bib9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0168-1605(02)00426-9","article-title":"Relations between the occurrence of resistance to antimicrobial growth promoters among enterococcus faecium isolated from broilers and broiler meat","volume":"84","author":"Emborg","year":"2003","journal-title":"Int. J. Food Microbiol."},{"key":"key\n\t\t\t\t20180302052415_bib10","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2527\/jas.2006-482","article-title":"Effects of feeding Salmonella enterica serovar Typhimurium or serovar Choleraesuis on growth performance and circulating insulin-like growth factor-I, tumor necrosis factor-\u03b1, and interleukin-1\u03b2 in weaned pigs","volume":"85","author":"Fraser","year":"2006","journal-title":"J. Anim. Sci."},{"key":"key\n\t\t\t\t20180302052415_bib11","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.imbio.2007.03.006","article-title":"Epidemiological and immunological evidence for the hygiene hypothesis","volume":"212","author":"Garn","year":"2007","journal-title":"Immunobiology"},{"key":"key\n\t\t\t\t20180302052415_bib12","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0093-691X(95)00225-W","article-title":"Effects of the whole extract and the chromatographic fractions of the pig placenta on lymphocyte proliferation and humoral immune response","volume":"44","author":"Georgieva","year":"1995","journal-title":"Theriogenology"},{"key":"key\n\t\t\t\t20180302052415_bib13","article-title":"Effectiveness of feed additive usage of antibacterial agents in swine and poultry production, Off","author":"Hays","year":"1977"},{"key":"key\n\t\t\t\t20180302052415_bib14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0378-8741(01)00371-3","article-title":"Inhibitory effect of a Korean traditional medicine, Honghwain-Jahage (water extracts of Carthamus tinctorius L. Seed and Hominis placenta) on interleukin-1-mediated bone resorption","volume":"79","author":"Hong","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"key\n\t\t\t\t20180302052415_bib15","doi-asserted-by":"crossref","first-page":"G1074","DOI":"10.1152\/ajpgi.1999.276.5.G1074","article-title":"I. Mucosal dendritic cells: Their specialized role in initiating t cell responses","volume":"276","author":"Iwasaki","year":"1999","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"key\n\t\t\t\t20180302052415_bib16","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.intimp.2007.07.011","article-title":"Human placenta promotes IL-8 expression through activation of JNK\/SAPK and transcription factors NF-\u03baB and AP-1 in PMA-differentiated THP-1 cells","volume":"7","author":"Kang","year":"2007","journal-title":"Int. Immunopharmacol."},{"key":"key\n\t\t\t\t20180302052415_bib17","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1093\/jn\/117.9.1629","article-title":"Immunologically mediated growth depression in chicks: Influence of feed intake, corticosterone and interleukin-1","volume":"117","author":"Klasing","year":"1987","journal-title":"J. Nutr."},{"key":"key\n\t\t\t\t20180302052415_bib18","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1740-0929.2006.00379.x","article-title":"Variations of blood corpuscles and immunoglobulin G of plasma and milk in placenta-fed sows","volume":"77","author":"Lee","year":"2006","journal-title":"Anim. Sci. J."},{"key":"key\n\t\t\t\t20180302052415_bib19","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1378\/chest.82.3.266","article-title":"Human alveolar macrophages suppress the proliferative response of peripheral blood lymphocytes","volume":"82","author":"McCombs","year":"1982","journal-title":"Chest"},{"key":"key\n\t\t\t\t20180302052415_bib20","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature10540","article-title":"Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules","volume":"479","author":"Moussion","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180302052415_bib21","volume-title":"Janeway's immunobiology.","author":"Murphy","year":"2008","edition":"7th ed."},{"key":"key\n\t\t\t\t20180302052415_bib22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2527\/jas.2006-153","article-title":"Immune responses of piglets to weaning stress: Impacts of photoperiod","volume":"85","author":"Niekamp","year":"2007","journal-title":"J. Anim. Sci."},{"key":"key\n\t\t\t\t20180302052415_bib23","article-title":"Why we get sick: The new science of Darwinian medicine","author":"Nesse","year":"1996"},{"key":"key\n\t\t\t\t20180302052415_bib24","doi-asserted-by":"crossref","first-page":"G257","DOI":"10.1152\/ajpgi.1999.277.2.G257","article-title":"IV. Paneth cell antimicrobial peptides and the biology of the mucosal barrier","volume":"277","author":"Ouellette","year":"1999","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"key\n\t\t\t\t20180302052415_bib25","doi-asserted-by":"crossref","first-page":"701","DOI":"10.5851\/kosfa.2011.31.5.701","article-title":"Immune modulation effect of pig placenta extracts in a mouse model: Putative use as a functional food supplement","volume":"31","author":"Park","year":"2011","journal-title":"Korean J. Food. Sci. Anim. Resour."},{"key":"key\n\t\t\t\t20180302052415_bib26","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1398-9995.2007.01462.x","article-title":"The role of the intestinal microbiota in the development of atopic disorders","volume":"62","author":"Penders","year":"2007","journal-title":"Allergy"},{"key":"key\n\t\t\t\t20180302052415_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2567.2008.03007.x","article-title":"Review series on helminths, immune modulation and the hygiene hypothesis: The broader implications of the hygiene hypothesis","volume":"126","author":"Rook","year":"2009","journal-title":"Immunology"},{"key":"key\n\t\t\t\t20180302052415_bib28","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nri2515","article-title":"The gut microbiota shapes intestinal immune responses during health and disease","volume":"9","author":"Round","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"key\n\t\t\t\t20180302052415_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0065-2776(07)96002-2","article-title":"Regulation of interferon \u03b3 during innate and adaptive immune responses","volume":"96","author":"Schoenborn","year":"2007","journal-title":"Adv. Immunol."},{"key":"key\n\t\t\t\t20180302052415_bib30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma: An overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"key\n\t\t\t\t20180302052415_bib31","doi-asserted-by":"crossref","first-page":"E232","DOI":"10.1371\/journal.pmed.0020232","article-title":"Agricultural antibiotics and human health","volume":"2","author":"Smith","year":"2005","journal-title":"PLoS Med."},{"key":"key\n\t\t\t\t20180302052415_bib32","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1054\/tuld.1998.0014","article-title":"Suppression of lymphoproliferation by alveolar macrophages in the guinea pig","volume":"79","author":"Zhang","year":"1998","journal-title":"Tuber. Lung Dis."}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jas\/article-pdf\/91\/5\/2405\/23974648\/2405.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T10:25:48Z","timestamp":1519986348000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/91\/5\/2405\/4717283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,1]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5,1]]}},"URL":"https:\/\/doi.org\/10.2527\/jas.2012-5208","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,5]]},"published":{"date-parts":[[2013,5,1]]}}}