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Reprod."},{"key":"key\n\t\t\t\t20180302051344_bib75","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1095\/biolreprod.109.077370","article-title":"Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle","volume":"81","author":"Sheldon","year":"2009","journal-title":"Biol. Reprod."},{"key":"key\n\t\t\t\t20180302051344_bib76","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jri.2010.02.006","article-title":"Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice","volume":"85","author":"Shima","year":"2010","journal-title":"J. Reprod. Immunol."},{"key":"key\n\t\t\t\t20180302051344_bib77","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1749-6632.1977.tb29431.x","article-title":"Progesterone and maintenance of pregnancy: Is progesterone Nature's immunosuppressant?","volume":"286","author":"Siiteri","year":"1977","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"key\n\t\t\t\t20180302051344_bib78","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.anireprosci.2007.12.015","article-title":"Postpartum suppression of ovarian activity with a Deslorelin implant enhanced uterine involution in lactating dairy cows","volume":"110","author":"Silvestre","year":"2009","journal-title":"Anim. Reprod. Sci."},{"key":"key\n\t\t\t\t20180302051344_bib79","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1095\/biolreprod45.5.655","article-title":"Hormonal regulation of uterine secretion of prostaglandin F2\u03b1 during luteolysis in ruminants","volume":"45","author":"Silvia","year":"1991","journal-title":"Biol. Reprod."},{"key":"key\n\t\t\t\t20180302051344_bib80","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1600-0897.1995.tb01143.x","article-title":"Effects of endometrial serpin-like proteins on immune responses in sheep","volume":"33","author":"Skopets","year":"1995","journal-title":"Am. J. Reprod. Immunol."},{"key":"key\n\t\t\t\t20180302051344_bib81","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.placenta.2011.11.026","article-title":"Rat placentation: An experimental model for investigating the hemochorial maternal-fetal interface","volume":"33","author":"Soares","year":"2012","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20180302051344_bib82","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2567.2004.01869.x","article-title":"Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset","volume":"112","author":"Somerset","year":"2004","journal-title":"Immunology"},{"key":"key\n\t\t\t\t20180302051344_bib83","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/00365540110026584","article-title":"Cytolytic T cells in the immune response to mycobacterium tuberculosis","volume":"33","author":"Stenger","year":"2001","journal-title":"Scand. J. Infect. Dis."},{"key":"key\n\t\t\t\t20180302051344_bib84","first-page":"157","article-title":"Leptin and adiponectin: From energy and metabolic dysbalance to inflammation and autoimmunity","volume":"43","author":"Stofkova","year":"2009","journal-title":"Endocr. Regl."},{"key":"key\n\t\t\t\t20180302051344_bib85","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0093-691X(00)00300-9","article-title":"Peripheral and intrauterine neutrophil function in the cow: The influence of endogenous and exogenous sex steroid hormones","volume":"53","author":"Subandrio","year":"2000","journal-title":"Theriogenology"},{"key":"key\n\t\t\t\t20180302051344_bib86","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.4049\/jimmunol.154.9.4476","article-title":"Regulatory role of \u03b3\u03b4 T cells in uterine intraepithelial lymphocytes in maternal antifetal immune response","volume":"154","author":"Suzuki","year":"1995","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20180302051344_bib87","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1262\/jrd.18170","article-title":"A review of gene expression in porcine endometrial lymphocytes, endothelium and trophoblast during pregnancy success and failure","volume":"53","author":"Tayade","year":"2007","journal-title":"J. Reprod. Dev."},{"key":"key\n\t\t\t\t20180302051344_bib88","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1177\/153537020222700913","article-title":"Natural-killer like cells in the sheep: Functional characterization and regulation by pregnancy-associated proteins","volume":"227","author":"Tekin","year":"2002","journal-title":"Exp. Biol. Med."},{"key":"key\n\t\t\t\t20180302051344_bib89","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0093-691X(02)01131-7","article-title":"Lymphocyte-mediated lysis of sheep chorion: Susceptibility of chorionic cells to third-party and maternal cytotoxic lymphocytes and presence of cells in the endometrium exhibiting cytotoxicity toward natural-killer cell targets","volume":"59","author":"Tekin","year":"2003","journal-title":"Theriogenology"},{"key":"key\n\t\t\t\t20180302051344_bib90","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1046\/j.8755-8920.2003.00125.x","article-title":"Regulation of numbers of macrophages in the endometrium of the sheep by systemic effects of pregnancy, local presence of the conceptus, and progesterone","volume":"51","author":"Tekin","year":"2004","journal-title":"Am. J. Reprod. 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Biol."},{"key":"key\n\t\t\t\t20180302051344_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3181\/00379727-128-32928","article-title":"Survival of skin homografts in uteri of pregnant and progesterone-estrogen treated rats","volume":"128","author":"Watnick","year":"1968","journal-title":"Proc. Soc. Exp. Med."},{"key":"key\n\t\t\t\t20180302051344_bib98","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1007\/s00018-011-0699-1","article-title":"Modulation of \u03b3\u03b4 T cell responses by TLR ligands","volume":"68","author":"Wesch","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"key\n\t\t\t\t20180302051344_bib99","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2460\/ajvr.1977.38.04.455","article-title":"Demonstration and quantitation of immunoglobulins in bovine serum, follicular fluid, and uterine and vaginal secretions with reference to bovine viral diarrhea","volume":"38","author":"Whitmore","year":"1977","journal-title":"Am. J. Vet. 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