{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T18:45:13Z","timestamp":1776105913678,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009496","name":"Oklahoma Agricultural Experiment Station","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009496","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ancillary therapy (ANC) is commonly provided in conjunction with an antimicrobial when treating calves for suspected bovine respiratory disease (BRD) in an attempt to improve the response to a suspected BRD challenge. The first experiment evaluated the effects of 3 ANC in combination with an antimicrobial in high-risk calves treated for BRD during a 56-d receiving period. Newly received crossbred steers (n = 516; initial BW = 217 \u00b1 20 kg) were monitored by trained personnel for clinical signs of BRD. Calves that met antimicrobial treatment criteria (n = 320) were then randomly assigned to experimental ANC treatment (80 steers\/experimental ANC treatment): intravenous flunixin meglumine injection (NSAID), intranasal viral vaccination (VACC), intramuscular vitamin C injection (VITC), or no ANC (NOAC). Animal served as the experimental unit for all variables except DMI and G:F (pen served as the experimental unit for DMI and G:F). Within calves treated 3 times for BRD, those receiving NOAC had lower (P &amp;lt; 0.01) clinical severity scores (severity scores ranged from 0 to 4 on the basis of observed clinical signs and severity) and heavier (P = 0.01) BW than those receiving NSAID, VACC, or VITC at the time of third treatment. Between the second and third BRD treatments, calves receiving NOAC had decreased (P &amp;lt; 0.01) daily BW loss (\u22120.13 kg ADG) compared with those receiving NSAID, VACC, or VITC (\u22121.30, \u22121.90, and \u22121.41 kg ADG, respectively). There were no differences in rectal temperature, combined mortalities and removals, or overall performance among the experimental ANC treatments. Overall, morbidity and mortality attributed to BRD across treatments were 66.5% and 13.2%, respectively. After the receiving period, a subset of calves (n = 126) were allocated to finishing pens to evaluate the effects ANC administration on finishing performance, carcass characteristics, and lung scores at harvest. Ultrasound estimates, BW, and visual appraisal were used to target a common physiological end point for each pen of calves. There were no differences among the experimental ANC observed during the finishing period (P \u2265 0.11). In summary, the use of NSAID, VACC, and VITC do not appear to positively impact clinical health and could potentially be detrimental to performance during the receiving period in high-risk calves receiving antimicrobial treatment for suspected BRD.<\/jats:p>","DOI":"10.2527\/jas.2015-9023","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T15:17:36Z","timestamp":1435850256000},"page":"3661-3674","source":"Crossref","is-referenced-by-count":33,"title":["Evaluation of multiple ancillary therapies used in combination with an antimicrobial in newly received high-risk calves treated for bovine respiratory disease1"],"prefix":"10.1093","volume":"93","author":[{"given":"B. K.","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Animal Science, Oklahoma State University, Stillwater 74078"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. L.","family":"Step","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Oklahoma State University, Stillwater 74078"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L.","family":"Maxwell","sequence":"first","affiliation":[{"name":"Department of Animal Science, Oklahoma State University, Stillwater 74078"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Wagner","sequence":"first","affiliation":[{"name":"Department of Animal Science, Oklahoma State University, Stillwater 74078"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Richards","sequence":"first","affiliation":[{"name":"Department of Animal Science, Oklahoma State University, Stillwater 74078"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"Krehbiel","sequence":"first","affiliation":[{"name":"Department of Animal Science, Oklahoma State University, Stillwater 74078"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"2020051822181909300_r1","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.2460\/ajvr.1990.51.09.1464","article-title":"Pharmacokinetics of flunixin meglumine in lactating cattle after single and multiple intramuscular and intravenous administrations","volume":"51","author":"Anderson","year":"1990","journal-title":"Am. J. Vet. Res."},{"key":"2020051822181909300_r2","first-page":"124","article-title":"Ancillary therapy for bovine respiratory disease","volume":"26","author":"Apley","year":"1994","journal-title":"Proc. Am. Assoc. Bov. Pract."},{"key":"2020051822181909300_r3","article-title":"Ancillary therapy of respiratory disease in food animals: What can we give in addition to an antibiotic?","author":"Apley","year":"2010"},{"key":"2020051822181909300_r4","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.2527\/2005.83102423x","article-title":"The physiological and production effects of increased dietary intake of vitamins E and C in feedlot cattle challenged with bovine herpesvirus 1","volume":"83","author":"Cusack","year":"2005","journal-title":"J. Anim. Sci."},{"key":"2020051822181909300_r5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cvfa.2010.03.005","article-title":"Control methods for bovine respiratory disease for feedlot cattle","volume":"26","author":"Edwards","year":"2010","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"2020051822181909300_r6","article-title":"Resflor Gold\u00ae: Florfenicol and flunixin meglumine (in 2-pyrrolidone and triacetin) injectable solution","volume-title":"FDA CVM Freedom of Information Summary. NADA 141-299.","author":"FDA","year":"2009"},{"key":"2020051822181909300_r7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cvfa.2011.12.003","article-title":"Evidence related to the use of ancillary drugs in bovine respiratory disease (anti-inflammatory and others): Are they justified or not?","volume":"28","author":"Francoz","year":"2012","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"2020051822181909300_r8","article-title":"Treatment of respiratory disease in U.S. feedlots","author":"NAHMS","year":"2001"},{"key":"2020051822181909300_r9","article-title":"Feedlot 2011. Part IV: Health and health management on U.S. feedlots with a capacity of 1000 or more head","author":"NAHMS","year":"2013"},{"key":"2020051822181909300_r10","article-title":"Beef quality assurance national guidelines","author":"National Cattlemen's Beef Association","year":"2001"},{"key":"2020051822181909300_r11","article-title":"Nutrient requirements of beef cattle: Update 2000","author":"NRC","year":"2000","edition":"7th ed."},{"key":"2020051822181909300_r12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1365-2885.1995.tb00589.x","article-title":"Pharmacokinetics of flunixin and its effect on prostaglandin F2a metabolite concentrations after oral and intravenous administration in heifers","volume":"18","author":"Odensvik","year":"1995","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"2020051822181909300_r13","article-title":"Livestock health series: Bovine respiratory disease. Div. Agric. Fact Sheet No. FSA3082","author":"Powell","year":"2013"},{"key":"2020051822181909300_r14","doi-asserted-by":"publisher","first-page":"3146","DOI":"10.2527\/jas.2008-0883","article-title":"Effects of commingling beef calves from different sources and weaning protocols during a forty-two-day receiving period on performance and bovine respiratory disease","volume":"86","author":"Step","year":"2008","journal-title":"J. Anim. Sci."},{"key":"2020051822181909300_r15","first-page":"1351","article-title":"The epidemiology of bovine respiratory disease: What is the evidence for preventive measures?","volume":"51","author":"Taylor","year":"2010","journal-title":"Can. Vet. J."},{"key":"2020051822181909300_r16","doi-asserted-by":"crossref","first-page":"140","DOI":"10.21423\/bovine-vol45no2p140-148","article-title":"A survey to describe current feeder cattle health and well-being program recommendations made by feedlot veterinary consultants in the United States and Canada","volume":"45","author":"Terrell","year":"2011","journal-title":"Bov. Pract."},{"key":"2020051822181909300_r17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.livsci.2011.05.003","article-title":"An evaluation of the effects of \u03b1-tocopherol and ascorbic acid in bovine respiratory disease complex occurring in feedlot calves after transport","volume":"141","author":"Urban-Chmiel","year":"2011","journal-title":"Livest. Sci."}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jas\/article-pdf\/93\/7\/3661\/33219683\/3661.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jas\/article-pdf\/93\/7\/3661\/33219683\/3661.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T20:32:44Z","timestamp":1717965164000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/93\/7\/3661\/4701859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,1]]},"references-count":17,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,1]]},"published-print":{"date-parts":[[2015,7,1]]}},"URL":"https:\/\/doi.org\/10.2527\/jas.2015-9023","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,7]]},"published":{"date-parts":[[2015,7,1]]}}}