{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T09:57:09Z","timestamp":1648720629487},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"name":"Diamond V Corporation"},{"name":"Food Safety and Enteric Pathogen Research Unit","award":["USDACRADA #DVRP127407"],"award-info":[{"award-number":["USDACRADA #DVRP127407"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"DOI":"10.2527\/jas.2016.0662","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T20:27:33Z","timestamp":1483648053000},"page":"279-290","source":"Crossref","is-referenced-by-count":0,"title":["Fermentation products as feed additives mitigate some ill-effects of heat stress in pigs1,2"],"prefix":"10.1093","volume":"95","author":[{"given":"S.","family":"Kumar","sequence":"first","affiliation":[{"name":"Food Safety and Enteric Pathogen Research Unit, National Animal Disease Center, Ames, IA, 50010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. E.","family":"Bass","sequence":"additional","affiliation":[{"name":"Food Safety and Enteric Pathogen Research Unit, National Animal Disease Center, Ames, IA, 50010"},{"name":"Diamond V, Cedar Rapids, IA, 52404"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bandrick","sequence":"additional","affiliation":[{"name":"Food Safety and Enteric Pathogen Research Unit, National Animal Disease Center, Ames, IA, 50010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L.","family":"Loving","sequence":"additional","affiliation":[{"name":"Food Safety and Enteric Pathogen Research Unit, National Animal Disease Center, Ames, IA, 50010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. L.","family":"Brockmeier","sequence":"additional","affiliation":[{"name":"Virus and Prion Research Unit, National Animal Disease Center, Ames, IA, 50010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Looft","sequence":"additional","affiliation":[{"name":"Food Safety and Enteric Pathogen Research Unit, National Animal Disease Center, Ames, IA, 50010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Trachsel","sequence":"additional","affiliation":[{"name":"Food Safety and Enteric Pathogen Research Unit, National Animal Disease Center, Ames, IA, 50010"},{"name":"Interdepartmental Microbiology Graduate Training Program, Iowa State University, Ames 50010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Madson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames 50010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Grinnell College, Grinnell, IA 50112"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. A.","family":"Casey","sequence":"additional","affiliation":[{"name":"Food Safety and Enteric Pathogen Research Unit, National Animal Disease Center, Ames, IA, 50010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Frank","sequence":"additional","affiliation":[{"name":"Diamond V, Cedar Rapids, IA, 52404"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. B.","family":"Stanton","sequence":"additional","affiliation":[{"name":"Food Safety and Enteric Pathogen Research Unit, National Animal Disease Center, Ames, IA, 50010"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. K.","family":"Allen","sequence":"additional","affiliation":[{"name":"Food Safety and Enteric Pathogen Research Unit, National Animal Disease Center, Ames, IA, 50010"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20180328133935_r1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev-micro-091213-113052","article-title":"Altered egos: Antibiotic effects on food animal microbiomes","volume":"68","author":"Allen","year":"2014","journal-title":"Annu. Rev. Microbiol."},{"key":"key\n\t\t\t\t20180328133935_r2","doi-asserted-by":"crossref","first-page":"a002584","DOI":"10.1101\/cshperspect.a002584","article-title":"Physiology and function of the tight junction","volume":"1","author":"Anderson","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"key\n\t\t\t\t20180328133935_r3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1089\/fpd.2011.0983","article-title":"Use estimates of in-feed antimicrobials in swine production in the United States","volume":"9","author":"Apley","year":"2012","journal-title":"Foodborne Pathog. Dis."},{"issue":"Suppl 1","key":"key\n\t\t\t\t20180328133935_r4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/jpn.12041","article-title":"Effect of dietary supplementation of prebiotics and probiotics on intestinal microarchitecture in broilers reared under cyclic heat stress","volume":"97","author":"Ashraf","year":"2013","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"key\n\t\t\t\t20180328133935_r5","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.2527\/jas.2011-4675","article-title":"Ruminant Nutrition Symposium: Ruminant production and metabolic responses to heat stress","volume":"90","author":"Baumgard","year":"2012","journal-title":"J. Anim. Sci."},{"key":"key\n\t\t\t\t20180328133935_r6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-animal-031412-103644","article-title":"Effects of heat stress on postabsorptive metabolism and energetics","volume":"1","author":"Baumgard","year":"2013","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"key\n\t\t\t\t20180328133935_r7","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: Minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"key\n\t\t\t\t20180328133935_r8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fnint.2013.00086","article-title":"Stress modulates intestinal secretory immunoglobulin A","volume":"7","author":"Campos-Rodriguez","year":"2013","journal-title":"Front. Integr. Neurosci."},{"key":"key\n\t\t\t\t20180328133935_r9","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.2527\/jas.2014-8108","article-title":"Effects of ambient temperature on energy and nitrogen utilization in lipopolysaccharide-challenged growing pigs","volume":"92","author":"Campos","year":"2014","journal-title":"J. Anim. Sci."},{"key":"key\n\t\t\t\t20180328133935_r10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.rvsc.2006.09.005","article-title":"Quantification of stress sensitive markers in single fecal samples do not accurately predict excretion of these in the pig","volume":"82","author":"Carlsson","year":"2007","journal-title":"Res. Vet. Sci."},{"key":"key\n\t\t\t\t20180328133935_r11","doi-asserted-by":"crossref","first-page":"G204","DOI":"10.1152\/ajpgi.00401.2005","article-title":"Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability","volume":"290","author":"Dokladny","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"key\n\t\t\t\t20180328133935_r12","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1152\/japplphysiol.00536.2015","article-title":"Intestinal epithelial barrier function and tight junction proteins with heat and exercise","volume":"120","author":"Dokladny","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"key\n\t\t\t\t20180328133935_r13","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1083\/jcb.17.2.375","article-title":"Junctional complexes in various epithelia","volume":"17","author":"Farquhar","year":"1963","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20180328133935_r14","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1021\/jf300249j","article-title":"Effects of selenium-enriched probiotics on heat shock protein mRNA levels in piglet under heat stress conditions","volume":"61","author":"Gan","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"key\n\t\t\t\t20180328133935_r15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.dci.2008.06.003","article-title":"Porcine T lymphocytes and NK cells\u2013an update","volume":"33","author":"Gerner","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"key\n\t\t\t\t20180328133935_r16","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1152\/physrev.00019.2012","article-title":"Claudins and the modulation of tight junction permeability","volume":"93","author":"Gunzel","year":"2013","journal-title":"Physiol. Rev."},{"key":"key\n\t\t\t\t20180328133935_r17","doi-asserted-by":"crossref","first-page":"208","DOI":"10.2527\/2005.831208x","article-title":"Hepatic corticosteroid-binding globulin (CBG) messenger RNA expression and plasma CBG concentrations in young pigs in response to heat and social stress","volume":"83","author":"Heo","year":"2005","journal-title":"J. Anim. Sci."},{"key":"key\n\t\t\t\t20180328133935_r18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40104-015-0014-3","article-title":"Study and use of the probiotic Lactobacillus reuteri in pigs: A review","volume":"6","author":"Hou","year":"2015","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"key\n\t\t\t\t20180328133935_r19","doi-asserted-by":"crossref","first-page":"E101","DOI":"10.2527\/jas.2008-1339","article-title":"Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects","volume":"87","author":"Lambert","year":"2009","journal-title":"J. Anim. Sci."},{"key":"key\n\t\t\t\t20180328133935_r20","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.2527\/jas.2008-1624","article-title":"Heat-stress-induced damage to porcine small intestinal epithelium associated with downregulation of epithelial growth factor signaling","volume":"87","author":"Liu","year":"2009","journal-title":"J. Anim. Sci."},{"key":"key\n\t\t\t\t20180328133935_r21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key\n\t\t\t\t20180328133935_r22","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.biologicals.2013.07.001","article-title":"Porcine granulocyte-colony stimulating factor (G-CSF) delivered via replication-defective adenovirus induces a sustained increase in circulating peripheral blood neutrophils","volume":"41","author":"Loving","year":"2013","journal-title":"Biologicals"},{"key":"key\n\t\t\t\t20180328133935_r23","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1016\/S0264-410X(99)00378-3","article-title":"Strain-dependent induction of cytokine profiles in the gut by orally administered Lactobacillus strains","volume":"18","author":"Maassen","year":"2000","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20180328133935_r24","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1128\/MCB.00811-10","article-title":"Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism","volume":"31","author":"Mashukova","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20180328133935_r25","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-2249.2005.02790.x","article-title":"Probiotic Lactobacillus-induced improvement in murine chronic inflammatory bowel disease is associated with the down-regulation of pro-inflammatory cytokines in lamina propria mononuclear cells","volume":"140","author":"Matsumoto","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"key\n\t\t\t\t20180328133935_r26","article-title":"National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals","author":"National Research Council","year":"2011","edition":"8th ed."},{"key":"key\n\t\t\t\t20180328133935_r27","doi-asserted-by":"crossref","first-page":"G418","DOI":"10.1152\/ajpgi.00166.2013","article-title":"Regional susceptibility to stress-induced intestinal injury in the mouse","volume":"305","author":"Novosad","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"key\n\t\t\t\t20180328133935_r28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jim.2004.10.002","article-title":"Gammadelta T-lymphocyte cytotoxic activity against Mycobacterium bovis analyzed by flow cytometry","volume":"297","author":"Olin","year":"2005","journal-title":"J. Immunol. Methods"},{"key":"key\n\t\t\t\t20180328133935_r29","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1095\/biolreprod.108.071779","article-title":"A single, mild, transient scrotal heat stress causes hypoxia and oxidative stress in mouse testes, which induces germ cell death","volume":"80","author":"Paul","year":"2009","journal-title":"Biol. Reprod."},{"key":"key\n\t\t\t\t20180328133935_r30","doi-asserted-by":"crossref","first-page":"e70215","DOI":"10.1371\/journal.pone.0070215","article-title":"Heat stress reduces intestinal barrier integrity and favors intestinal glucose transport in growing pigs","volume":"8","author":"Pearce","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180328133935_r31","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.2527\/jas.2013-6759","article-title":"Heat stress and reduced plane of nutrition decreases intestinal integrity and function in pigs","volume":"91","author":"Pearce","year":"2013","journal-title":"J. Anim. Sci."},{"key":"key\n\t\t\t\t20180328133935_r32","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.2527\/jas.2014-8407","article-title":"Short-term exposure to heat stress attenuates appetite and intestinal integrity in growing pigs","volume":"92","author":"Pearce","year":"2014","journal-title":"J. Anim. Sci."},{"key":"key\n\t\t\t\t20180328133935_r33","first-page":"841","article-title":"Measurement of immunoglobulin concentrations in the feces of healthy dogs","volume":"11","author":"Peters","year":"2004","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"key\n\t\t\t\t20180328133935_r34","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0304-3940(02)01423-4","article-title":"Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data","volume":"339","author":"Ramakers","year":"2003","journal-title":"Neurosci. Lett."},{"key":"key\n\t\t\t\t20180328133935_r35","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1017\/S1751731111002448","article-title":"Adaptation to hot climate and strategies to alleviate heat stress in livestock production","volume":"6","author":"Renaudeau","year":"2012","journal-title":"Animal"},{"key":"key\n\t\t\t\t20180328133935_r36","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.2527\/jas.2012-5689","article-title":"Effect of thermal heat stress on energy utilization in two lines of pigs divergently selected for residual feed intake","volume":"91","author":"Renaudeau","year":"2013","journal-title":"J. Anim. Sci."},{"key":"key\n\t\t\t\t20180328133935_r37","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.2527\/jas.2010-3329","article-title":"A meta-analysis of the effects of high ambient temperature on growth performance of growing-finishing pigs","volume":"89","author":"Renaudeau","year":"2011","journal-title":"J. Anim. Sci."},{"key":"key\n\t\t\t\t20180328133935_r38","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3945\/an.112.003376","article-title":"Nutritional interventions to alleviate the negative consequences of heat stress","volume":"4","author":"Rhoads","year":"2013","journal-title":"Adv. Nutr."},{"key":"key\n\t\t\t\t20180328133935_r39","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.molcel.2010.10.006","article-title":"The heat shock response: Life on the verge of death","volume":"40","author":"Richter","year":"2010","journal-title":"Mol. Cell"},{"key":"key\n\t\t\t\t20180328133935_r40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13028-015-0094-2","article-title":"Infrared skin temperature measurements for monitoring health in pigs: A review","volume":"57","author":"Soerensen","year":"2015","journal-title":"Acta Vet. Scand."},{"key":"key\n\t\t\t\t20180328133935_r41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2527\/2005.831243x","article-title":"Diet modifications to improve finishing pig growth performance and pork quality attributes during periods of heat stress","volume":"83","author":"Spencer","year":"2005","journal-title":"J. Anim. Sci."},{"key":"key\n\t\t\t\t20180328133935_r42","doi-asserted-by":"crossref","first-page":"E52","DOI":"10.3168\/jds.S0022-0302(03)74040-5","article-title":"Economic losses from heat stress by US livestock industries","volume":"86","author":"St-Pierre","year":"2003","journal-title":"J. Dairy Sci."},{"key":"key\n\t\t\t\t20180328133935_r43","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3945\/jn.110.135657","article-title":"Regulation of tight junction permeability by intestinal bacteria and dietary components","volume":"141","author":"Ulluwishewa","year":"2011","journal-title":"J. Nutr."},{"key":"key\n\t\t\t\t20180328133935_r44","doi-asserted-by":"crossref","first-page":"e0138975","DOI":"10.1371\/journal.pone.0138975","article-title":"Differences in susceptibility to heat stress along the chicken intestine and the protective effects of galacto-oligosaccharides","volume":"10","author":"Varasteh","year":"2015","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180328133935_r45","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1017\/S0007114514004231","article-title":"Down-regulation of monocarboxylate transporter 1 (MCT1) gene expression in the colon of piglets is linked to bacterial protein fermentation and pro-inflammatory cytokine-mediated signalling","volume":"113","author":"Villodre Tudela","year":"2015","journal-title":"Br. J. Nutr."},{"key":"key\n\t\t\t\t20180328133935_r46","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","article-title":"Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension","volume":"92","author":"Wang","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20180328133935_r47","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1152\/jappl.1995.79.3.732","article-title":"Thermal stresses reduce natural killer cell cytotoxicity","volume":"79","author":"Won","year":"1995","journal-title":"J. Appl. Physiol."},{"key":"key\n\t\t\t\t20180328133935_r48","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cbpa.2010.01.008","article-title":"Effect of heat stress on the porcine small intestine: A morphological and gene expression study","volume":"156","author":"Yu","year":"2010","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jas\/article-pdf\/95\/1\/279\/23803588\/279.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T18:43:49Z","timestamp":1522262629000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/95\/1\/279\/4703006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1,1]]}},"URL":"https:\/\/doi.org\/10.2527\/jas.2016.0662","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,1]]},"published":{"date-parts":[[2017,1,1]]}}}