{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T16:56:49Z","timestamp":1767200209296,"version":"build-2238731810"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"DOI":"10.2527\/jas.2016.1078","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T15:28:41Z","timestamp":1486654121000},"page":"671-680","source":"Crossref","is-referenced-by-count":9,"title":["Age-related effects on markers of inflammation and cartilage metabolism in response to an intra-articular lipopolysaccharide challenge in horses"],"prefix":"10.1093","volume":"95","author":[{"given":"M. K.","family":"Kahn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Coverdale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Leatherwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. E.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Dabareiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. N.","family":"Bradbery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Millican","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"T. H.","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20180208014719_r1","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1053\/jvet.2001.28430","article-title":"Synovial fluid cytokines and eicosanoids as markers of joint disease in horses","volume":"30","author":"Bertone","year":"2001","journal-title":"Vet. Surg."},{"key":"key\n\t\t\t\t20180208014719_r2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1136\/ard.57.11.697","article-title":"Matrix metalloproteinase activity in equine synovial fluid: Influence of age, osteoarthritis, and osteochondrosis","volume":"57","author":"Brama","year":"1998","journal-title":"Ann. Rheum. Dis."},{"key":"key\n\t\t\t\t20180208014719_r3","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1365-2885.2009.01131.x","article-title":"Age-related differences in prostaglandin E2 synthesis by equine cartilage explants and synoviocytes","volume":"33","author":"Briston","year":"2009","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"key\n\t\t\t\t20180208014719_r4","doi-asserted-by":"crossref","first-page":"R35","DOI":"10.1186\/ar2640","article-title":"Inflammatory mediators and cartilage biomarkers in synovial fluid after a single inflammatory insult: A longitudinal experimental study","volume":"11","author":"de Grauw","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"key\n\t\t\t\t20180208014719_r5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2746\/042516406777749236","article-title":"Arthrogenic lameness of the fetlock: Synovial fluid markers of inflammation and cartilage turnover in relation to clinical joint pain","volume":"38","author":"de Grauw","year":"2006","journal-title":"Equine Vet. J."},{"key":"key\n\t\t\t\t20180208014719_r6","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/B1-41-600123-9\/50085-1","article-title":"Synovial joint biology and pathobiology","volume-title":"Equine surgery.","author":"Frisbie","year":"2006"},{"key":"key\n\t\t\t\t20180208014719_r7","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.joca.2008.03.008","article-title":"Changes in synovial fluid and serum biomarkers with exercise and early osteoarthritis in horses","volume":"16","author":"Frisbie","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"key\n\t\t\t\t20180208014719_r8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.tvjl.2010.04.011","article-title":"Biomarkers of cartilage turnover. Part 1: Markers of collagen degradation and synthesis","volume":"185","author":"Garvican","year":"2010","journal-title":"Vet. J."},{"key":"key\n\t\t\t\t20180208014719_r9","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/9781118269312","article-title":"Normal physiological data","volume-title":"Horse owner's veterinary handbook.","author":"Gore","year":"2008"},{"key":"key\n\t\t\t\t20180208014719_r10","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/1529-0131(200101)44:1<120::AID-ANR16>3.0.CO;2-X","article-title":"Early degradation of type IX and type II collagen with the onset of experimental inflammatory arthritis","volume":"44","author":"Kojima","year":"2001","journal-title":"Arthritis Rheum."},{"key":"key\n\t\t\t\t20180208014719_r11","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.2527\/1998.7641216x","article-title":"Statistical analysis of repeated measures data using SAS procedures","volume":"76","author":"Littell","year":"1998","journal-title":"J. Anim. Sci."},{"key":"key\n\t\t\t\t20180208014719_r12","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.2527\/jas.2012-5981","article-title":"Influence of an intra-articular lipopolysaccharide challenge on markers of inflammation and cartilage metabolism in young horses","volume":"91","author":"Lucia","year":"2013","journal-title":"J. Anim. Sci."},{"key":"key\n\t\t\t\t20180208014719_r13","article-title":"Joint disease in the horse","author":"McIlwraith","year":"1996"},{"key":"key\n\t\t\t\t20180208014719_r14","article-title":"Nutrient requirements of horses","author":"NRC","year":"2007","edition":"6th rev. ed"},{"key":"key\n\t\t\t\t20180208014719_r15","doi-asserted-by":"crossref","first-page":"ii78","DOI":"10.1136\/ard.61.suppl_2.ii78","article-title":"Type II collagen degradation and its regulation in articular cartilage in osteoarthritis","volume":"61","author":"Poole","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"key\n\t\t\t\t20180208014719_r16","first-page":"1","article-title":"Anatomy and physiology of synovial joints","volume-title":"Joint disease in the horse.","author":"Todhunter","year":"1996"},{"key":"key\n\t\t\t\t20180208014719_r17","first-page":"980","article-title":"Pathophysiology of synovitis: Clinical signs and examinations in horses","volume":"26","author":"Todhunter","year":"1990","journal-title":"Compend. Contin. Educ. Pract. Vet."},{"key":"key\n\t\t\t\t20180208014719_r18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.joca.2008.07.014","article-title":"Osteochondral injury increases type II collagen degradation products (C2C) in synovial fluid of Thoroughbred racehorses","volume":"17","author":"Trumble","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"key\n\t\t\t\t20180208014719_r19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2746\/0425164054530740","article-title":"Influence of repeated arthrocentesis and exercise on synovial fluid concentrations of nitric oxide, prostaglandin E2 and glycosaminoglycans in healthy equine joints","volume":"37","author":"van den Boom","year":"2005","journal-title":"Equine Vet. J."}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jas\/article-pdf\/95\/2\/671\/23798973\/671.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T01:47:58Z","timestamp":1518054478000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/95\/2\/671\/4701978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,1]]},"references-count":19,"aliases":["10.2527\/jas2016.1078"],"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2,1]]}},"URL":"https:\/\/doi.org\/10.2527\/jas.2016.1078","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,2]]},"published":{"date-parts":[[2017,2,1]]}}}