{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:17:40Z","timestamp":1791328660465,"version":"4.3.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":337,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["2013-01919"],"award-info":[{"award-number":["2013-01919"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To determine the effects of poor maternal nutrition on offspring body and organ growth during gestation, pregnant Western White-faced ewes (n = 82) were randomly assigned into a 3 \u00d7 4 factorial treatment structure at d 30.2 \u00b1 0.2 of gestation (n = 5 to 7 ewes per treatment). Ewes were individually fed 100% (control), 60% (restricted) or 140% (over) of NRC requirements for TDN. Ewes were euthanized at d 45, 90 or 135 of gestation or underwent parturition (birth) and tissues were collected from the offspring (n = 10 to 15 offspring per treatment). Offspring from control, restricted and overfed ewes are referred to as CON, RES and OVER, respectively. Ewe data were analyzed as a completely randomized design and offspring data were analyzed as a split-plot design using PROC MIXED. Ewe BW did not differ at d 30 (P \u2265 0.43), however restricted ewes weighed less than overfed and overfed were heavier than controls at d 45, and restricted weighed less and overfed were heavier than controls at d 90 and 135 and birth (P \u2264 0.05). Ewe BCS was similar at d 30, 45 and 90 (P \u2264 0.07), however restricted ewes scored lower than control at d 135 and birth (P \u2264 0.05) and over ewes scored higher than control at d 135 (P \u2264 0.05) but not at birth (P = 0.06). A maternal diet by day of gestation interaction indicated that at birth the body weight (BW) of RES offspring was less than CON and OVER (P \u2264 0.04) and heart girth of RES was smaller than CON and OVER (P \u2264 0.004). There was no interaction of maternal diet and day of gestation on crown-rump, fetal, or nose occipital length, or orbit or umbilical diam. (P \u2265 0.31). A main effect of maternal diet indicated that the RES crown-rump length was shorter than CON and OVER (P \u2264 0.05). An interaction was observed for liver, kidney and renal fat (P \u2264 0.02). At d 45 the liver of RES offspring was larger than CON and OVER (P \u2264 0.002), but no differences observed at d 90, 135 or birth (P \u2265 0.07). At d 45, the kidneys of OVER offspring were larger than CON and RES (P \u2264 0.04), but no differences observed at d 90, 135 or birth (P \u2265 0.60). At d 135, OVER had more perirenal fat than CON and RES (P \u2264 0.03), and at birth RES had more perirenal fat than CON and OVER (P \u2264 0.04). There was no interaction observed for offspring heart weight, length or width, kidney length, adrenal gland weight, loin eye area or rib width (P \u2265 0.09). In conclusion, poor maternal nutrition differentially alters offspring body size and organ growth depending on the stage of gestation.<\/jats:p>","DOI":"10.2527\/tas2016.0002","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T22:05:51Z","timestamp":1544565951000},"page":"16-25","source":"Crossref","is-referenced-by-count":41,"title":["Fetal and organ development at gestational days 45, 90, 135 and at birth of lambs exposed to under- or over-nutrition during gestation1,2,3"],"prefix":"10.1093","volume":"1","author":[{"given":"S. M.","family":"Pillai","sequence":"first","affiliation":[{"name":"Department of Animal Science, University of Connecticut, Storrs 06269"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Animal Science, University of Connecticut, Storrs 06269"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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E.","family":"Govoni","sequence":"first","affiliation":[{"name":"Department of Animal Science, University of Connecticut, Storrs 06269"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,2,1]]},"reference":[{"issue":"12","key":"2020051902190327400_r1","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.bbadis.2010.03.002","article-title":"Maternal nutrition, low nephron number and arterial hypertension in later life","volume":"1802","author":"Benz","year":"2010","journal-title":"Biochim. Biophys. Acta."},{"key":"2020051902190327400_r2","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-10-S11-S2","article-title":"Facilitating functional annotation of chicken microarray data","volume-title":"BMC Bioinformatics.","author":"Buza","year":"2009"},{"key":"2020051902190327400_r3","unstructured":"Caton\n              J. S.\n            , HessB. A.\n          2010. 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