{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T16:09:28Z","timestamp":1750435768006},"reference-count":0,"publisher":"HMP Communications, LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Manag Prev"],"abstract":"<jats:p>BACKGROUND: Incontinence-associated dermatitis (IAD) is one of the most common complications of incontinence. Improved diaper designs can minimize the occurrence of IAD. PURPOSE: To develop a novel diaper design to minimize the damaging effects of incontinence on the epidermal barrier. METHODS: An optimized diaper design was tested for surface dryness (ie, rewet), maintenance of a skin-adapted surface pH of 5.5, and ability to protect epidermal barrier function from an alkaline pH 10.7 challenge. RESULTS: The diapers released a mean (standard deviation [SD]) of 1.2 (0.2) mg\/cm2 of solution under pressure after the first loading and a mean of 2.9 (1.7) mg\/cm2 after the second loading. The surface pH remained between 4.5 and 5.5 over 5 hours. In healthy skin, transepidermal water loss (TEWL) increased by a mean of 3.43 (4.67) g\/m2\/h after the alkaline urine solution challenge with the new diaper design versus a mean of 8.38 (5.67) g\/m2\/h with a cellulose patch (P &lt; .001) as a control. The mean erythema readings were 1.18 (1.30) g\/m2\/h for the new design and 2.56 (1.25) g\/m2\/h for the cellulose patches (P &lt; .001). CONCLUSION: The new diaper design minimizes rewetting, maintains an acidic surface, and protects the epidermal barrier against an alkaline pH challenge. This design may help prevent IAD.<\/jats:p>","DOI":"10.25270\/wmp.23057","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T19:21:38Z","timestamp":1712949698000},"source":"Crossref","is-referenced-by-count":1,"title":["The Protective Effect of a New Absorbent Incontinence Design Against an Alkaline pH Challenge on the Epidermal Barrier"],"prefix":"10.25270","volume":"70","author":[{"given":"Olga","family":"Vechter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yana","family":"Arlouskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niuosha","family":"Sanaeifar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Kesselmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Beer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janina","family":"Tiemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Segiet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Rabczenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Smola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10906","published-online":{"date-parts":[[2024]]},"container-title":["Wound Management &amp; Prevention"],"original-title":[],"deposited":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T19:21:48Z","timestamp":1712949708000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hmpgloballearningnetwork.com\/site\/wmp\/empirical-studies\/protective-effect-new-absorbent-incontinence-design-against-alkaline-ph"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.25270\/wmp.23057","relation":{},"ISSN":["2640-5237"],"issn-type":[{"value":"2640-5237","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}