{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:02:16Z","timestamp":1791442936904,"version":"4.3.3"},"reference-count":0,"publisher":"HMP Communications, LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wound Manag Prev"],"abstract":"<jats:p>BACKGROUND: Venous leg ulcers (VLUs) are associated with various physical and social adverse effects for patients but also contribute to a significant socioeconomic burden. PURPOSE: To examine the clinical performance and safety of a collagen-alginate dressing in combination with standard wound care in non-healing VLUs. METHODS: In an observational, explorative, single-center study, VLUs of 60 patients were covered with a collagen-alginate dressing. Wounds were assessed during 5 visits over a 4-week period. At the final visit, health care professionals gave an overall assessment of the dressing. Outcome parameters were wound area reduction, wound pain, wound-related quality of life (QoL), and incidence of adverse events. RESULTS: The mean wound area decreased (17.8 \u00b1 11.2 cm\u00b2 versus 11.4 \u00b1 9.0 cm\u00b2; P &lt; .0001), and 4 patients achieved complete closure. Wound pain decreased after 2 weeks, and intake of analgesics reduced. Patients\u2019 wound-related QoL improved and a correlation between the well-being sub-score and wound area reduction was found. All health care professionals rated the collagen-alginate dressing as \u2018very good\u2019 or \u2018good.\u2019 CONCLUSION: The collagen-alginate dressing is safe and effective in promoting healing and addressing the pain of VLUs. It also improves patients\u2019 QoL, possibly by reducing wound area, pain, and exudate.<\/jats:p>","DOI":"10.25270\/wmp.23113","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T20:21:23Z","timestamp":1736972483000},"source":"Crossref","is-referenced-by-count":2,"title":["Observational Study of Venous Leg Ulcer Treated With a Native Collagen-Alginate Dressing and the Impact on Wound-Related Quality of Life"],"prefix":"10.25270","volume":"70","author":[{"given":"Alisha","family":"Oropallo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farisha","family":"Baksh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Del Pin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Isgro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10906","published-online":{"date-parts":[[2024]]},"container-title":["Wound Management &amp; Prevention"],"original-title":[],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T20:21:27Z","timestamp":1736972487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hmpgloballearningnetwork.com\/site\/wmp\/empirical-studies\/observational-study-venous-leg-ulcer-treated-native-collagen-alginate"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.25270\/wmp.23113","relation":{},"ISSN":["2640-5245"],"issn-type":[{"value":"2640-5245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}