{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:01:22Z","timestamp":1780596082978,"version":"3.54.1"},"reference-count":0,"publisher":"HMP Communications, LLC","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wounds"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>Advanced wound treatments are derived primarily from human placental membranes or animal tissue sources and composed of cellular and acellular dermal substitutes. The use of advanced wound treatments is practitioner directed and individualized to the wound characteristics. A multidisciplinary approach to wound closure is necessary, including the use of advanced treatments (eg, human umbilical cord derivatives) to achieve durable resolution of hard-to-heal wounds. In this case series, DHUC was used as an alternative to amniotic and amnion\/chorion allografts for closure of a deep heel ulcer and a wound of the plantar aspect of the foot. The allografts were applied after wound closure had stalled with previous treatment attempts, which demonstrates use of DHUC in a staged approach to wound bed preparation and closure. The thickness and durability of DHUC allowed it to be used more like a skin graft for deep wounds. The meshed product can be expanded to provide a cost-effective solution to cover larger wound surfaces. It can be applied in an outpatient setting, thus avoiding more invasive and costly procedures (eg, split-thickness skin grafts). The use of umbilical allografts in the current report resulted in closure of stalled wounds and avoided hospitalization, thus reducing overall costs.<\/jats:p>","DOI":"10.25270\/wnds\/21126","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T16:21:53Z","timestamp":1666023713000},"page":"e91-e95","source":"Crossref","is-referenced-by-count":3,"title":["Expandable Dehydrated Human Umbilical Cord Allograft for the Management of Nonhealing Lower Extremity Wounds in Patients With Diabetes: A Case Series"],"prefix":"10.25270","volume":"34","author":[{"given":"Matthew","family":"Garoufalis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Tettelbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10906","published-online":{"date-parts":[[2022]]},"container-title":["Wounds: a compendium of clinical research and practice"],"original-title":[],"deposited":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T16:21:56Z","timestamp":1666023716000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hmpgloballearningnetwork.com\/site\/wounds\/case-series\/expandable-dehydrated-human-umbilical-cord-allograft-management-nonhealing"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022]]},"published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.25270\/wnds\/21126","relation":{},"ISSN":["1044-7946","1943-2704"],"issn-type":[{"value":"1044-7946","type":"print"},{"value":"1943-2704","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}