{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T05:17:14Z","timestamp":1719551834495},"reference-count":0,"publisher":"HMP Communications, LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wounds"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction. Lower extremity ulcer is a severe complication in patients with autoimmune disease, and treatment is difficult and time-consuming. L-PRF has been widely used in mammalian regenerative medicine owing to its ease of use and low cost. However, few studies have been published on the application of L-PRF in autoimmune-associated ulcers. Case Report. This case report discusses a 26-year-old male patient with SLE who presented to the authors' institution with a chronic lower extremity ulcer of 8 months\u2019 duration. He received once-weekly L-PRF treatment along with standard wound care. After 15 treatments, the ulcer was completely epithelialized, with a healing rate of 3.8 cm2 per week. Conclusions. This case report provides a promising therapeutic strategy for the treatment of autoimmune-associated ulcers. More robust data from case series and RCTs are required to further evaluate the clinical efficacy of L-PRF in refractory ulcers in patients with autoimmune disease.<\/jats:p>","DOI":"10.25270\/wnds\/21154","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T18:47:12Z","timestamp":1683312432000},"page":"e1-e6","source":"Crossref","is-referenced-by-count":1,"title":["Leukocyte- and Platelet-rich Fibrin Treatment of Chronic Lower Extremity Ulcer in a Patient with Systemic Lupus Erythematosus: A Case Report"],"prefix":"10.25270","volume":"35","author":[{"given":"Chunyu","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinqin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiying","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10906","published-online":{"date-parts":[[2023]]},"container-title":["Wounds: a compendium of clinical research and practice"],"original-title":[],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T18:47:35Z","timestamp":1683312455000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hmpgloballearningnetwork.com\/site\/wounds\/case-report\/leukocyte-and-platelet-rich-fibrin-treatment-chronic-lower-extremity-ulcer"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.25270\/wnds\/21154","relation":{},"ISSN":["1044-7946","1943-2704"],"issn-type":[{"value":"1044-7946","type":"print"},{"value":"1943-2704","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}