{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:20:01Z","timestamp":1784920801867,"version":"3.55.0"},"reference-count":0,"publisher":"HMP Communications, LLC","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wounds"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:p>Introduction. MTX-LPD is a complication that occurs during MTX treatment. Skin lesions in MTX-LPD are often subcutaneous nodules with occasional necrosis and ulceration. Although MTX-LPD regression is frequently observed upon discontinuation of oral MTX treatment, delayed diagnosis of MTX-LPD with associated ulceration may lead to ulcer enlargement and the need for surgical procedures such as skin grafts. Case Report. A 74-year-old female was diagnosed with RA and administered MTX for 3 years and 8 months. The patient presented with a 2-month-old ulcer on the dorsum of the hand. The ulcer size was 6.5 cm \u00d7 5 cm, and it was surrounded by an embankment tumor measuring 7 cm \u00d7 6 cm. Although a definitive diagnosis could not be made based on the biopsy specimen, excision of the ulcer-containing mass confirmed MTX-LPD diagnosis. MTX was discontinued, and free-flap reconstruction was performed 3 weeks after the first surgery. The postoperative period was uneventful, and MTX-LPD recurrence was not observed 10 months after the second surgery. Conclusion. Although MTX-LPD with ulceration is rare, it should be considered in cases of refractory ulcers in patients with RA. The discontinuation of MTX based on early MTX-LPD diagnosis is critical to avoid surgical procedures such as skin grafts and flap reconstruction.<\/jats:p>","DOI":"10.25270\/wnds\/22103","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T20:59:18Z","timestamp":1689195558000},"page":"e189-e192","source":"Crossref","is-referenced-by-count":3,"title":["Methotrexate-associated Lymphoproliferative Disorder Presenting as an Ulcer With Tendon Exposure on the Dorsum of the Hand: A Case Report and Literature Review"],"prefix":"10.25270","volume":"35","author":[{"given":"Haruka","family":"Kawamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Shimbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Koshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10906","published-online":{"date-parts":[[2023]]},"container-title":["Wounds: a compendium of clinical research and practice"],"original-title":[],"deposited":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T20:59:26Z","timestamp":1689195566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hmpgloballearningnetwork.com\/site\/wounds\/case-report\/methotrexate-associated-lymphoproliferative-disorder-presenting-ulcer"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023]]},"published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.25270\/wnds\/22103","relation":{},"ISSN":["1044-7946","1943-2704"],"issn-type":[{"value":"1044-7946","type":"print"},{"value":"1943-2704","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}