{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T12:30:52Z","timestamp":1788093052714,"version":"build-2803163510"},"reference-count":0,"publisher":"HMP Communications, LLC","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wounds"],"abstract":"<jats:p>Background. Photobiomodulation (PBM) has shown promising results in accelerating wound healing and modulating inflammation. Objective. To evaluate the feasibility of PBM therapy in treating lower limb wounds in people with diabetes. Materials and Methods. This was a 12-week prospective, pilot, multicenter, nonrandomized clinical trial. The 25 participants were divided into the intervention group (IG), in which a laser was applied once a week (660 nm, 100 mW power, 2 J\/cm^{2}, continuous wave, visible beam) and hydrogel was applied daily, and the control group, in which hydrogel was applied daily. Participants older than 18 years with a diagnosis of diabetes mellitus and with lower limb wounds smaller than 100 cm\u00b2 were included. Participants with lupus, pyoderma gangrenosum, and Stevens-Johnson syndrome were excluded. Comparisons between the groups were performed using the Mann-Whitney U test, and comparisons between different time points were performed using the Friedman test. The Fisher exact test was used to assess associations between groups and qualitative variables. Results. No statistically significant difference in wound area was observed when comparing the 4 time points evaluated between groups. However, there was a significant difference when comparing the 4 time points in the IG (P &lt; .0083). No significant difference between groups was observed in the expression of the cytokines investigated. Conclusion. Application of PBM at an intensity of 2 J\/cm\u00b2 once a week did not produce measurable changes in the cytokine gene expression. However, significant reduction in wound area and an improvement in tissue repair were observed in patients treated with PBM.<\/jats:p>","DOI":"10.25270\/wnds\/25012","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T18:28:12Z","timestamp":1773167292000},"source":"Crossref","is-referenced-by-count":1,"title":["Photobiomodulation in Wounds of Individuals With Diabetes: A Nonrandomized Pilot Study"],"prefix":"10.25270","volume":"37","author":[{"suffix":"MSc","given":"Beatriz Barbieri","family":"Bortolozo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"MSc","given":"Amanda Ramiro Gomes da","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PhD","given":"Thais Paulino","family":"Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PhD","given":"Bianca Campos","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PhD","given":"Joseane","family":"Morari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PhD","given":"Fl\u00e1via Cristina","family":"Zanchetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PhD","given":"Eliana Pereira","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PhD","given":"Beatriz Guitton Renaud Baptista de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"BSN, PhD","given":"Bruna Maiara Ferreira Barreto","family":"Pires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PhD","given":"Priscila Peruzzo","family":"Apolinario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"RN, PhD","given":"Maria Helena M.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10906","published-online":{"date-parts":[[2025,11]]},"container-title":["Wounds: a compendium of clinical research and practice"],"original-title":[],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T18:28:13Z","timestamp":1773167293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hmpgloballearningnetwork.com\/site\/wounds\/original-research\/photobiomodulation-wounds-individuals-diabetes-nonrandomized-pilot"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"URL":"https:\/\/doi.org\/10.25270\/wnds\/25012","relation":{},"ISSN":["1943-2704"],"issn-type":[{"value":"1943-2704","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}