{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:41:01Z","timestamp":1773243661006,"version":"3.50.1"},"reference-count":0,"publisher":"HMP Communications, LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Wounds"],"abstract":"<jats:p>Background. Diabetic foot ulcers (DFUs) significantly affect patients and health care systems, often resulting in amputation and high morbidity. Objective. To evaluate whether cellular, acellular, and matrix-like products (CAMPs) are more effective than the standard of care in reducing lower limb amputation (LLA) risk and improving survival in DFU patients. Methods. This retrospective cohort study used a proprietary database to identify patients with type 1 or type 2 diabetes and foot ulcers. Two cohorts were compared: those receiving debridement and those receiving CAMPs. Propensity score matching (PSM) balanced baseline characteristics. The primary outcome was 5-year LLA risk and amputation-free survival. Results. Before PSM, the CAMPs cohort (n = 2273) had higher rates of comorbidities compared with the debridement-only cohort (n = 31,050). After matching, cohorts were well-balanced (n = 2272 each). Treatment with CAMPs significantly reduced the risk of LLA compared with debridement alone, with a 4.9% absolute risk reduction (95% CI, -7.4 to \u22122.4%; P &lt; .0001) and a 24% relative risk reduction (risk ratio, 0.763; 95% CI, 0.664-0.876). Kaplan-Meier analysis demonstrated improved 5-year amputation-free survival in the CAMPs cohort (75.7% vs 71.3. Conclusion. CAMP therapy significantly reduces LLA risk and improves amputation-free survival in DFU patients.<\/jats:p>","DOI":"10.25270\/wnds\/25051","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:14:49Z","timestamp":1773173689000},"source":"Crossref","is-referenced-by-count":0,"title":["Preserving Limbs and Lives: The Role of Cellular, Acellular, and Matrix-like Products in Diabetic Foot Ulcer Care"],"prefix":"10.25270","author":[{"given":"Abigail","family":"Royfman","sequence":"first","affiliation":[{"name":"^{1}University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA; ^{2}Jobst Vascular Institute\/ProMedica, Toledo, OH, USA; ^{3}Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Lux","sequence":"additional","affiliation":[{"name":"^{1}University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA; ^{2}Jobst Vascular Institute\/ProMedica, Toledo, OH, USA; ^{3}Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennedy","family":"Couch","sequence":"additional","affiliation":[{"name":"^{1}University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA; ^{2}Jobst Vascular Institute\/ProMedica, Toledo, OH, USA; ^{3}Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molynna","family":"Nguyen","sequence":"additional","affiliation":[{"name":"^{1}University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA; ^{2}Jobst Vascular Institute\/ProMedica, Toledo, OH, USA; ^{3}Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"Wong","sequence":"additional","affiliation":[{"name":"^{1}University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA; ^{2}Jobst Vascular Institute\/ProMedica, Toledo, OH, USA; ^{3}Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Gong","sequence":"additional","affiliation":[{"name":"^{1}University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA; ^{2}Jobst Vascular Institute\/ProMedica, Toledo, OH, USA; ^{3}Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Simman","sequence":"additional","affiliation":[{"name":"^{1}University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA; ^{2}Jobst Vascular Institute\/ProMedica, Toledo, OH, USA; ^{3}Department of Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10906","published-online":{"date-parts":[[2026,2]]},"container-title":["Wounds: a compendium of clinical research and practice"],"original-title":[],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:14:50Z","timestamp":1773173690000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hmpgloballearningnetwork.com\/site\/wounds\/original-research\/preserving-limbs-and-lives-role-cellular-acellular-and-matrix"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.25270\/wnds\/25051","relation":{},"ISSN":["1943-2704"],"issn-type":[{"value":"1943-2704","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]}}}