{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:39:56Z","timestamp":1778737196594,"version":"3.51.4"},"reference-count":126,"publisher":"MIS Quarterly","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:p>Containing skyrocketing health care costs is imperative. Toward that end, prescriptive analytics that analyzes health care data to recommend optimal decisions is both relevant and crucial. We develop a novel prescriptive analytics method to improve the cost effectiveness in clinical decision making (CDM), a critical health care dimension that can greatly benefit from analytics. Effective prescriptive analytics for CDM has to address its probabilistic, cost-sensitive, and investment-related characteristics simultaneously. Unlike existing methods that often overlook the investment-related characteristic, the proposed method accounts for all of these characteristics. Specifically, our method considers two sets of costs associated with clinical decisions\u2014before and after an investment\u2014in combination with the probabilities of cost changes due to the investment. In contrast, prevalent methods only emphasize one set of costs, before an investment. Furthermore, the proposed method involves both clinical and investment decisions, whereas existing methods ignore investment decisions. Empirical evaluations with two real-world clinical data sets indicate that the proposed method consistently and significantly outperforms several salient methods from previous research, thereby demonstrating the value of addressing the investment-related characteristic in efforts to improve CDM.<\/jats:p>","DOI":"10.25300\/misq\/2021\/14372","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T10:50:21Z","timestamp":1620125421000},"page":"83-115","source":"Crossref","is-referenced-by-count":22,"title":["A Prescriptive Analytics Method for Cost Reduction in Clinical Decision Making"],"prefix":"10.25300","volume":"45","author":[{"given":"Xiao","family":"Fang","sequence":"first","affiliation":[{"name":"Alfred Lerner College of Business and Economics, University of Delaware, 357 Purnell Hall, Newark, DE 19716 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The Cost-Effectiveness of Cardiac Monitoring in Breast Cancer Patients Who Have Received Cardiotoxic Therapies, unpublished Ph.D. Dissertation, University of Texas, Austin."},{"key":"2025082212234636100_b74-03_14372_ra_fanggaohu","unstructured":"Manyika, J., Chui, M., Brown, B., Bughin, J., Dobbs, R., Roxburgh, C., and Byers, A.\u20082011. \u201cBig Data: The Next Frontier for Innovation, Competition, and Productivity,\u201d McKinsey Global Institute (https:\/\/bigdatawg.nist.gov\/pdf\/MGI_big_data_full_report.pdf; accessed n February 21, 2019)."},{"key":"2025082212234636100_b75-03_14372_ra_fanggaohu","first-page":"270","article-title":"Class Probability Estimation and Cost-Sensitive Classification Decisions","author":"Margineantu","year":"2002"},{"issue":"4","key":"2025082212234636100_b76-03_14372_ra_fanggaohu","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1287\/isre.2013.0484","article-title":"Blunting Damocles\u2019 Sword: A Longitudinal Model of Healthcare IT Impact on 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