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However, AI is less helpful in developing drugs when there is no existing therapy. AI is also less helpful for drugs that are either entirely novel or those that are incremental \u201cfollowon\u201d drugs. Examining AI skills, a key component of AI innovation capability, we find that the main effect of AI innovation capability comes from employees possessing the combination of AI skills and domain expertise in drug discovery as opposed to employees possessing AI skills only. Having the combination is key because developing and improving AI tools is an iterative process requiring synthesizing inputs from both AI and domain experts during both the development and the operational stages of the tool. Taken together, our study sheds light on both the advantages and the limitations of using AI in drug discovery and how to effectively manage AI resources for drug development.<\/jats:p>","DOI":"10.25300\/misq\/2021\/16565","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T16:20:58Z","timestamp":1631722858000},"page":"1451-1482","source":"Crossref","is-referenced-by-count":133,"title":["AI on Drugs: Can Artificial Intelligence Accelerate Drug Development? 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