{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:27:44Z","timestamp":1786116464402,"version":"build-2736575974"},"reference-count":0,"publisher":"Swiss Chemical Society","issue":"6","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chimia"],"abstract":"<jats:p>Chirality is often discussed in chemistry as if it were a matter of degree: molecules are described as \u2018more\u2019 or \u2018less\u2019 chiral depending on the number of stereogenic elements, the magnitude of helical twist, or the extent of structural distortion. From a mathematical perspective, however, chirality is strictly binary\u2014a structure is either superimposable on its mirror image or it is not. This apparent contradiction reflects a deeper issue: the classifications commonly used in chemistry obscure a more fundamental distinction. In this Perspective, we revisit molecular chirality through the lens of geometry and topology. We demonstrate that the vast majority of familiar stereochemical motifs\u2014classified as central, axial, planar, or helical chirality\u2014are topologically trivial and belong to a single class in which enantiomers are interconvertible by continuous deformation of the molecular geometry, without bond breaking. But there exists a fundamentally distinct class: topologically chiral molecules, such as certain interlocked and knotted architectures, whose enantiomers cannot be interconverted by any continuous deformation, even under the assumption of complete conformational flexibility. Viewed from this perspective, while some classification remains useful, extensive classification risks adding unnecessary complexity without improving our understanding of how chirality functions in practice. What ultimately matters to chemists is identifying the conditions under which chirality can be observed, preserved, and used. This Perspective does not aim to provide a comprehensive, mathematically rigorous unification of stereochemical classes, but rather to illustrate, through selected model systems, the relationship between topological chirality and classical, rigidly chiral frameworks.<\/jats:p>","DOI":"10.2533\/chimia.2026.405","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:48:41Z","timestamp":1782258521000},"page":"405-410","source":"Crossref","is-referenced-by-count":0,"title":["How Much Chirality is Enough?"],"prefix":"10.2533","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6107-2310","authenticated-orcid":false,"given":"Michel","family":"Rickhaus","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, University of Geneva, CH-1205 Geneva"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0013-4116","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"\u0160olomek","sequence":"additional","affiliation":[{"name":"Van\u2019t Hoff Institute for Molecular Sciences, University of Amsterdam, 1090 GD Amsterdam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5595-431X","authenticated-orcid":false,"given":"Michal","family":"Jur\u00ed\u010dek","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Zurich, CH-8057 Zurich"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1442","published-online":{"date-parts":[[2026,6,24]]},"container-title":["CHIMIA"],"original-title":[],"link":[{"URL":"https:\/\/www.chimia.ch\/chimia\/article\/download\/2026_405\/2026_405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.chimia.ch\/chimia\/article\/download\/2026_405\/2026_405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T10:22:02Z","timestamp":1786011722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.chimia.ch\/chimia\/article\/view\/2026_405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6,24]]}},"URL":"https:\/\/doi.org\/10.2533\/chimia.2026.405","relation":{},"ISSN":["2673-2424","0009-4293"],"issn-type":[{"value":"2673-2424","type":"electronic"},{"value":"0009-4293","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,24]]}}}