{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:52:31Z","timestamp":1791550351425,"version":"4.3.4"},"reference-count":0,"publisher":"Swiss Chemical Society","issue":"9","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chimia"],"abstract":"<jats:p>The increasing structural complexity of active pharmaceutical ingredients (APIs) poses significant challenges for early-phase drug substance development, where speed and reliability are critical for clinical readiness. To address these limitations, we present an integrated, technology-driven framework combining AI-enabled route scouting, high-throughput experimentation (HTE), model-based process optimization (Design2OptimizeTM) and AI-assisted co-crystal prediction. Case studies demonstrating substantial benefits, including reductions in synthetic step count, material consumption, experimental effort, and overall development time will be discussed. This integrated approach de-risks early-phase development, supports more sustainable development practices, and enables strategic decision-making, offering a paradigm shift toward faster, smarter, and more resilient drug substance development.<\/jats:p>","DOI":"10.2533\/chimia.2026.576","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:39:38Z","timestamp":1790725178000},"page":"576-582","source":"Crossref","is-referenced-by-count":0,"title":["Fast-Tracking Drug Substance Development with AI, HTE, and Digital Twins"],"prefix":"10.2533","volume":"80","author":[{"given":"Aaron","family":"Johnson","sequence":"first","affiliation":[{"name":"Advanced Chemistry Technologies, Lonza AG, CH-3930 Visp, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichola","family":"McCann","sequence":"additional","affiliation":[{"name":"Advanced Chemistry Technologies, Lonza AG, CH-3930 Visp, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Oeschger","sequence":"additional","affiliation":[{"name":"Advanced Chemistry Technologies, Lonza AG, CH-3930 Visp, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Advanced Chemistry Technologies, Lonza AG, CH-3930 Visp, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Wagschal","sequence":"additional","affiliation":[{"name":"Advanced Chemistry Technologies, Lonza AG, CH-3930 Visp, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1442","published-online":{"date-parts":[[2026,9,30]]},"container-title":["CHIMIA"],"original-title":[],"link":[{"URL":"https:\/\/www.chimia.ch\/chimia\/article\/download\/2026_576\/2026_576","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.chimia.ch\/chimia\/article\/download\/2026_576\/2026_576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:02:34Z","timestamp":1791547354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.chimia.ch\/chimia\/article\/view\/2026_576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9,30]]}},"URL":"https:\/\/doi.org\/10.2533\/chimia.2026.576","relation":{},"ISSN":["2673-2424","0009-4293"],"issn-type":[{"value":"2673-2424","type":"electronic"},{"value":"0009-4293","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,30]]}}}