{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:53:03Z","timestamp":1791550383364,"version":"4.3.4"},"reference-count":0,"publisher":"Swiss Chemical Society","issue":"9","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chimia"],"abstract":"<jats:p>Ketene and diketene are cornerstone intermediates of industrial chemistry, enabling synthesis of a wide range of functional products. Beyond their established applications, side products of ketene dimerization provide access to 1,3-cyclobutanedione and triketene chemistry. This review highlights industrial relevance, reactivity, scalable access to 1,3-cyclobutanedione via the dione salt, and emerging applications of cyclobutane motifs in pharmaceuticals, emphasizing opportunities for further derivatization and process development.<\/jats:p>","DOI":"10.2533\/chimia.2026.617","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:40:22Z","timestamp":1790725222000},"page":"617-622","source":"Crossref","is-referenced-by-count":0,"title":["Ketene, Diketene, and 1,3-Cyclobutanedione Chemistry \u2013 Industrial Relevance, Reactivity, and Emerging Applications of Cyclobutane Motifs"],"prefix":"10.2533","volume":"80","author":[{"given":"Philipp","family":"Kohler","sequence":"first","affiliation":[{"name":"Tech. Evaluation & Development, Arxada AG, CH-3930 Visp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Taeschler","sequence":"additional","affiliation":[{"name":"Tech. Evaluation & Development, Arxada AG, CH-3930 Visp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne Jan","family":"Stepen","sequence":"additional","affiliation":[{"name":"Tech. Evaluation & Development, Arxada AG, CH-3930 Visp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Schmid","sequence":"additional","affiliation":[{"name":"Tech. Evaluation & Development, Arxada AG, CH-3930 Visp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Mayerhoeffer","sequence":"additional","affiliation":[{"name":"Tech. Evaluation & Development, Arxada AG, CH-3930 Visp"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1442","published-online":{"date-parts":[[2026,9,30]]},"container-title":["CHIMIA"],"original-title":[],"link":[{"URL":"https:\/\/www.chimia.ch\/chimia\/article\/download\/2026_617\/2026_617","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.chimia.ch\/chimia\/article\/download\/2026_617\/2026_617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:03:01Z","timestamp":1791547381000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.chimia.ch\/chimia\/article\/view\/2026_617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9,30]]}},"URL":"https:\/\/doi.org\/10.2533\/chimia.2026.617","relation":{},"ISSN":["2673-2424","0009-4293"],"issn-type":[{"value":"2673-2424","type":"electronic"},{"value":"0009-4293","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,30]]}}}