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\u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0441\u043b\u0443\u0447\u0430\u0435 \u0440\u0435\u0448\u0435\u043d\u0438\u0435 \u043d\u0443\u0436\u043d\u043e \u043f\u0440\u0438\u043d\u0438\u043c\u0430\u0442\u044c \u0441 \u0443\u0447\u0435\u0442\u043e\u043c \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e\u0441\u0442\u0435\u0439 \u043a\u043e\u043d\u043a\u0440\u0435\u0442\u043d\u043e\u0433\u043e \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430.<\/jats:p>\n                                                                                            <jats:p>In recent years, the life expectancy of patients with hemophilia has been steadily increasing as a result of significant expansion of treatment options. In this context, the prevalence of cardiovascular diseases (CVDs) among such patients has been also increasing. Since antithrombotic agents (antiplatelet agents and anticoagulants) represent a mandatory component of therapy for the majority of CVDs, and patients with hemophilia are at a very high risk of bleeding, the choice of treatment tactics is challenging. The situation is further complicated by the fact that, to date, data from clinical studies on the effectiveness and safety of antiplatelet agents and anticoagulants in patients with hemophilia are extremely limited. In this context, the significance of the challenge of managing CVDs in patients with hemophilia is indisputable; the expert community is engaged in substantial efforts to address this issue. This publication presents the results of the efforts of a working group, consisting of experts from 5 international scientific societies. The group formulated the most important practical issues related to the management of patients with hemophilia and various CVDs, analyzed the available scientific literature data and, based on this analysis, developed and ranked 3 degrees of convincing practical recommendations for the use of antithrombotic therapy in patients with hemophilia. The recommendations presented are intended for a wide range of physicians who may encounter patients with hemophilia and CVDs in their clinical practice. The recommendations provide general guidance for choosing appropriate therapy. However, in each clinical case, the decision must be made based on the characteristics of the individual patient.<\/jats:p>","DOI":"10.25555\/thr.2024.2.1095","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T14:40:30Z","timestamp":1719067230000},"source":"Crossref","is-referenced-by-count":0,"title":["Antithrombotic therapy in hemophilia patients"],"prefix":"10.25555","author":[{"given":"\u041d.\u0418.","family":"\u0417\u043e\u0437\u0443\u043b\u044f","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"19448","container-title":["\u0422\u0440\u043e\u043c\u0431\u043e\u0437, \u0433\u0435\u043c\u043e\u0441\u0442\u0430\u0437 \u0438 \u0440\u0435\u043e\u043b\u043e\u0433\u0438\u044f"],"original-title":["\u0410\u043d\u0442\u0438\u0442\u0440\u043e\u043c\u0431\u043e\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0433\u0435\u043c\u043e\u0444\u0438\u043b\u0438\u0435\u0439"],"language":"ru","deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T14:40:33Z","timestamp":1719067233000},"score":1,"resource":{"primary":{"URL":"https:\/\/gefest.rads-doi.org\/gefest\/project\/edit\/15439#:~:text=https%3A\/\/thrj.ru\/index.php\/thrj\/article\/view\/499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,22]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6,22]]}},"URL":"https:\/\/doi.org\/10.25555\/thr.2024.2.1095","relation":{},"ISSN":["2078-1008"],"issn-type":[{"value":"2078-1008","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,22]]}}}