{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:40:55Z","timestamp":1774366855667,"version":"3.50.1"},"reference-count":53,"publisher":"Consilium Medicum","issue":"1","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>The review presents the results of a number of experimental and clinical studies proving the prospects of using L-carnitine in the clinic of internal diseases. Due to the antioxidant and antihypoxant properties, the additional use of L-carnitine in addition to the main etiopathogenetic therapy is prescribed by cardiologists, nephrologists, neurologists, gerontologists. Experimental studies we conducted earlier showed no effect of L-carnitine on the activity of the P450 CYP 3A4 system, which reduces the likelihood of drug-drug interaction at the level of metabolism of drugs metabolized by P450 3A4. When using L-carnitine as part of complex pharmacotherapy, the drug has an increased safety profile in comorbid patients taking L-carnitine.<\/jats:p>","DOI":"10.26442\/00403660.2019.01.000040","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T11:37:16Z","timestamp":1552649836000},"page":"114-120","source":"Crossref","is-referenced-by-count":9,"title":["Significance of L-carnitine in internal medicine"],"prefix":"10.26442","volume":"91","author":[{"given":"Zh M","family":"Sizova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E V","family":"Shikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A A","family":"Makhova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"ref1","unstructured":"\u041ay\u043aec \u0412.\u0413., \u0421\u044b\u0447\u0435\u0432 \u0414.\u0410. \u041fepco\u043da\u043b\u0438\u0437\u0438po\u0432a\u043d\u043da\u044f \u043ce\u0434\u0438\u0446\u0438\u043da: \u043do\u0432\u044be \u0432o\u0437\u043co\u0436\u043doc\u0442\u0438 \u0434\u043b\u044f \u043fo\u0432\u044b\u0448e\u043d\u0438\u044f \u0431e\u0437o\u043fac\u043doc\u0442\u0438 \u0444ap\u043ca\u043ao\u0442epa\u043f\u0438\u0438. 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Semin Dial. 2002;15(1):7","DOI":"10.1046\/j.1525-139x.2002.0020a.x"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00402"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.29296\/25877305-2018-04-09"},{"key":"ref49","unstructured":"\u0413\u0443\u0441\u0435\u0432 \u0415.\u0418., \u041a\u0443\u0437\u0438\u043d \u0412.\u041c., \u041a\u043e\u043b\u0435\u0441\u043d\u0438\u043a\u043e\u0432\u0430 \u0422.\u041d. \u0438 \u0434\u0440. \u041a\u0430\u0440\u043d\u0438\u0442\u0438\u043d - \u0432\u0435\u0434\u0443\u0449\u0438\u0439 \u0444\u0430\u043a\u0442\u043e\u0440 \u0440\u0435\u0433\u0435\u043d\u0435\u0440\u0430\u0446\u0438\u0438 \u043d\u0435\u0440\u0432\u043d\u043e\u0439 \u0442\u043a\u0430\u043d\u0438. \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u043e\u043d\u043d\u044b\u0439 \u0432\u0435\u0441\u0442\u043d\u0438\u043a. 1999 (\u0444\u0435\u0432\u0440\u0430\u043b\u044c):11-23."},{"key":"ref50","unstructured":"\u0411\u043e\u0434\u044b\u0445\u043e\u0432 \u041c.\u041a., \u0421\u0442\u0430\u0445\u043e\u0432\u0441\u043a\u0430\u044f \u041b.\u0412., \u0421\u0430\u043b\u0438\u043c\u043e\u0432 \u041a.\u0410., \u0421\u0443\u043d \u0427\u0435\u0440 \u0418. \u041e\u0446\u0435\u043d\u043a\u0430 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u0438 \u0438 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u0430 \u00ab\u042d\u043b\u044c\u043a\u0430\u0440\u00bb (\u043b\u0435\u0432\u043e\u043a\u0430\u0440\u043d\u0438\u0442\u0438\u043d) \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0432 \u043e\u0441\u0442\u0440\u043e\u043c \u043f\u0435\u0440\u0438\u043e\u0434\u0435 \u0438\u0448\u0435\u043c\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0438\u043d\u0441\u0443\u043b\u044c\u0442\u0430 \u0432 \u043a\u0430\u0440\u043e\u0442\u0438\u0434\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u0435. \u0420\u041c\u0416 - \u041d\u0435\u0432\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2011;11:3-6."},{"key":"ref51","unstructured":"\u0427\u0438\u0447\u0430\u043d\u043e\u0432\u0441\u043a\u0430\u044f \u041b.\u0412., \u0411\u0430\u0445\u0430\u0440\u0435\u0432\u0430 \u041e.\u041d., \u0421\u043e\u0440\u043e\u043a\u0438\u043d\u0430 \u041a.\u0411. \u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u0438 \u0438 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 L-\u043a\u0430\u0440\u043d\u0438\u0442\u0438\u043d\u0430 \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0432 \u0440\u0430\u043d\u043d\u0435\u043c \u0432\u043e\u0441\u0441\u0442\u0430\u043d\u043e\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u043c \u043f\u0435\u0440\u0438\u043e\u0434\u0435 \u0438\u0448\u0435\u043c\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0438\u043d\u0441\u0443\u043b\u044c\u0442\u0430. \u0416\u0443\u0440\u043d\u0430\u043b \u043d\u0435\u0432\u0440\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043f\u0441\u0438\u0445\u0438\u0430\u0442\u0440\u0438\u0438 \u0438\u043c \u0421.\u0421. \u041a\u043e\u0440\u0441\u0430\u043a\u043e\u0432\u0430. 2017;12(\u0412\u044b\u043f. 2):65-9."},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Makhova A.A, Shich E.V, Kukes V.G, Sizova O.S, Ramenskaya G.V, Shumyantseva V.V, Bulko T.V, Archakov A.I, Usanov S.A. Electroanalysis of cytochrome P450 3A4 catalytic properties with nanostructured electrodes: the influence of vitamin B group on diclofenac metabolism. 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