{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:35:30Z","timestamp":1782398130676,"version":"3.54.5"},"reference-count":37,"publisher":"Consilium Medicum","issue":"5","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim: to propose diagnostic algorithm of IgG4-related disease (IgG4-RD). Materials and methods. One center retrospective research. 52 pts with IgG4-RD were included. The diagnosis was proved histologically and immunohistochemically. 48 out of 52 pts received treatment. Treatment included one of the following schemes (along with low oral glucocorticoids): rituximab monotherapy, cyclophosphamide monotherapy or their combination. Results. The mean age was 47.4\u00b15.9 years, the mean age of the disease onset was 43.9\u00b116.0 years. Median time before the diagnosis was 24 months. The most often sites of IgG4-RD were lacrimal (63.5%), salivary (46.2%) glands, lungs (48%), lymph nodes (34.6%) and retroperitoneum (17.3%). In clinical picture the leading complain was organ enlargement, but not its dysfunction. Pain was characteristic for retroperitoneum localization. In 56.8% of pts with IgG4-related syalo - and\/or dacryoadenitis there was association with ear - nose - throat organs affection. In 4 pts (7.7%) IgG4-RD was combined with some malignant disease, including MALT-lymphoma of lacrimal glands. Irreversible organ damage as an IgG4-RD outcome had 15.4% of pts. The main laboratory markers of IgG4-RD were ESR elevation (38.5%), blood eosinophilia (9.6%), immunological disturbances (serum total IgG and IgG4 elevation, IgE elevation, antinuclear antibodies, rheumatoid factor detection, hypocomplementemia). Serum IgG4 level &gt;1.35 g\/l was elevated in 88% of pts and correlated with the number of affected organs (Spearman correlation coefficient 0.39, Student\u2019s test, \u0440=0.0056). Monoclonal serum secretion and B-cell clonality in the tissue was detected in 4 (23.5%) out of 17 pts, but not all of them had both signs. Conclusion. Based on the analysis of clinical and laboratory characteristics of IgG4-RD a diagnostic algorithm was proposed that enhances the detection and examination of the patients with suspected IgG4-RD.<\/jats:p>","DOI":"10.26442\/00403660.2019.05.000236","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T11:37:45Z","timestamp":1561549065000},"page":"40-48","source":"Crossref","is-referenced-by-count":6,"title":["Clinical and laboratory characteristics of IgG4-realated disease and its diagnostic algorithm"],"prefix":"10.26442","volume":"91","author":[{"given":"E V","family":"Sokol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V I","family":"Vasilyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S G","family":"Palshina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N V","family":"Kokosadze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N A","family":"Probatova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Kovrigina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T N","family":"Safonova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E B","family":"Rodionova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I V","family":"Gaiduk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E I","family":"Selifanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18344","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/mod"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60720-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.08.013"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Carruthers M.N, Khosroshahi A, Augustin T, Deshpande V, Stone J.H. 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Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Aug;118(2):e40-3. doi: 10.1016\/j. oooo.2014.01.023","DOI":"10.1016\/j.oooo.2014.01.023"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Lindau R.H, Su Y.B, Kobayashi R, Smith R.B. Immunoglobulin G4-related sclerosing disease of the paranasal sinus. Head & Neck. 2013;35(10):321-4. https:\/\/doi.org\/10.1002\/hed.23175","DOI":"10.1002\/hed.23175"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2011.07.017"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.07"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.4103\/0971-3026.134384"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205187"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3171\/2016.11.SPINE16924"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Voulgarelis M, Moutsopoulos H.M. 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