{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T11:22:11Z","timestamp":1709551331360},"reference-count":41,"publisher":"Consilium Medicum","issue":"6","license":[{"start":{"date-parts":[[2019,6,15]],"date-time":"2019-06-15T00:00:00Z","timestamp":1560556800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>History of antithrombotic therapy in cardiology has almost 70 years, and it is undoubtedly the importance of the achievements of Soviet scientists. The creation of a domestic thrombolytic fibrinolysin at MSU G. V. Andreenko, its first successful application in patients with myocardial infarction (MI), conducted by E. I. Chazov, and then by other domestic researchers, played a crucial role in proving the need for a quick restoration of the patency of infarct related artery. The world's first intracoronary thrombolysys, conducted by E. I. Chazov, together with the staff of the all-Union cardiological center, allowed to verify thrombosis as the cause of MI and demonstrate the effectiveness of thrombolytic therapy. One of the most important achievements of domestic researchers of the 60s of the last century was the understanding of the need not only to eliminate the thrombus by using of fibrinolysin, but also to prevent its recurrence, with administration of heparin with transition to VKA. This conclusion, in fact, is a statement of the need for long - term antithrombotic therapy in patients with \u0441oronary artery disease (CAD). Over the past 70 years, antithrombotic therapy in CAD has undergone significant changes, this was facilitated by the undoubted progress in understanding the mechanisms of atherosclerosis and thrombosis development. Nevertheless, the basic principles of antithrombotic therapy, laid down by the national school in the 60s of the last century, have survived.<\/jats:p>","DOI":"10.26442\/00403660.2019.06.000296","type":"journal-article","created":{"date-parts":[[2019,8,4]],"date-time":"2019-08-04T23:15:48Z","timestamp":1564960548000},"page":"19-24","source":"Crossref","is-referenced-by-count":1,"title":["Antithrombotic therapy of coronary heart disease: time - tested essential principles"],"prefix":"10.26442","volume":"91","author":[{"given":"E. P","family":"Panchenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2019,6,15]]},"reference":[{"key":"ref1","unstructured":"\u0427\u0430\u0437\u043e\u0432 \u0415.\u0418. \u0420\u043e\u043b\u044c \u0441\u043f\u0430\u0437\u043c\u0430 \u0441\u043e\u0441\u0443\u0434\u043e\u0432 \u0432 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0438 \u0430\u043d\u0442\u0438\u0441\u0432\u0435\u0440\u0442\u044b\u0432\u0430\u044e\u0449\u0435\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b \u043a\u0440\u043e\u0432\u0438. \u0411\u044e\u043b\u043b\u0435\u0442\u0435\u043d\u044c \u044d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u043e\u0439 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u044b. 1960,(3):21-5."},{"key":"ref2","unstructured":"\u0427\u0430\u0437\u043e\u0432 \u0415.\u0418., \u0410\u043d\u0434\u0440\u0435\u0435\u043d\u043a\u043e \u0413.\u0412. \u041f\u0435\u0440\u0432\u044b\u0439 \u043e\u043f\u044b\u0442 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0442\u0440\u043e\u043c\u0431\u043e\u0437\u0430 \u043e\u0442\u0435\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u043b\u0438\u0437\u0438\u043d\u043e\u043c. \u041a\u0430\u0440\u0434\u0438\u043e\u043b\u043e\u0433\u0438\u044f. 1962,(4):59-64."},{"key":"ref3","unstructured":"\u041f\u0430\u043d\u0447\u0435\u043d\u043a\u043e \u0412.\u041c. \u041e\u043f\u044b\u0442 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u043b\u0438\u0437\u0438\u043d\u0430. \u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0440\u0445\u0438\u0432. 1964,(1):43-50."},{"key":"ref4","unstructured":"\u041c\u0430\u0437\u0443\u0440 \u041d.\u0410., \u0421\u0430\u043f\u0435\u0433\u0438\u043d\u0430 \u0422.\u0421., \u0422\u0440\u0443\u0431\u0435\u0446\u043a\u043e\u0439 \u0410.\u0412. \u041e \u0441\u043e\u0441\u0443\u0434\u043e\u0440\u0430\u0441\u0448\u0438\u0440\u044f\u044e\u0449\u0435\u043c \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0438 \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u043b\u0438\u0437\u0438\u043d\u0430. \u041a\u0430\u0440\u0434\u0438\u043e\u043b\u043e\u0433\u0438\u044f. 1965,(1):58."},{"key":"ref5","unstructured":"\u042f\u043d\u0443\u0448\u043a\u0435\u0432\u0438\u0447\u0443\u0441 \u0417.\u041a., \u0411\u043b\u0443\u0436\u0430\u0441 \u0418.\u041d. \u041e\u0441\u043d\u043e\u0432\u043d\u044b\u0435 \u043f\u043e\u043b\u043e\u0436\u0435\u043d\u0438\u044f \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0430\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u043e\u0432 \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0441\u0440\u0435\u0434\u0441\u0442\u0432. \u041a\u0430\u0443\u043d\u0430\u0441: \u0428\u0432\u0438\u0435\u0441\u0430, 1966."},{"key":"ref6","unstructured":"\u0413\u0435\u0444\u0442\u0435\u0440 \u0410.\u0418., \u041f\u043e\u043d\u043e\u043c\u0430\u0440\u0435\u0432\u0430 \u0410.\u0413., \u0416\u0434\u0430\u043d\u043e\u0432 \u042e.\u0415. \u041b\u0435\u0447\u0435\u043d\u0438\u0435 \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u043b\u0438\u0437\u0438\u043d\u043e\u043c \u0438 \u0433\u0435\u043f\u0430\u0440\u0438\u043d\u043e\u043c \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0438\u043d\u0444\u0430\u0440\u043a\u0442\u043e\u043c \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430 \u0438 \u0441 \u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u043c\u0438 \u0442\u0440\u043e\u043c\u0431\u043e\u044d\u043c\u0431\u043e\u043b\u0438\u044f\u043c\u0438. \u0422\u0435\u0437\u0438\u0441\u044b \u0434\u043e\u043a\u043b\u0430\u0434\u043e\u0432 8-\u0433\u043e \u0441\u044a\u0435\u0437\u0434\u0430 \u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u043e\u0432 \u0423\u043a\u0440\u0430\u0438\u043d\u0441\u043a\u043e\u0439 \u0421\u0421\u0420. \u041a\u0438\u0435\u0432, 1965. \u0421. 65."},{"key":"ref7","unstructured":"\u041f\u0430\u043d\u0447\u0435\u043d\u043a\u043e \u0412.\u041c. \u041e\u043f\u044b\u0442 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u043b\u0438\u0437\u0438\u043d\u0430 \u0412\u0440\u0430\u0447\u0435\u0431\u043d\u043e\u0435 \u0434\u0435\u043b\u043e. 1966,(11):8."},{"key":"ref8","unstructured":"\u041f\u0430\u043d\u0447\u0435\u043d\u043a\u043e \u0412.\u041c. \u0421\u0432\u0435\u0440\u0442\u044b\u0432\u0430\u044e\u0449\u0430\u044f \u0438 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0441\u0432\u0435\u0440\u0442\u044b\u0432\u0430\u044e\u0449\u0430\u044f \u0441\u0438\u0441\u0442\u0435\u043c\u0430 \u0432 \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u0435\u0437\u0435 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u0438 \u0432\u043d\u0443\u0442\u0440\u0438\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0445 \u0442\u0440\u043e\u043c\u0431\u043e\u0437\u043e\u0432. \u041c.: \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430, 1967."},{"key":"ref9","unstructured":"\u041c\u0430\u0437\u0443\u0440 \u041d.\u0410., \u0420\u0443\u0434\u0430 \u041c.\u042f., \u041a\u0430\u0446 \u0418.\u0410., \u041e\u0432\u0440\u0443\u0446\u043a\u0438\u0439 \u042f.\u0421. \u0418\u0437\u0443\u0447\u0435\u043d\u0438\u0435 \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432 \u043d\u0430 \u044d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u044b\u0439 \u0442\u0440\u043e\u043c\u0431\u043e\u0437. \u041a\u0430\u0440\u0434\u0438\u043e\u043b\u043e\u0433\u0438\u044f. 1967,(7):67."},{"key":"ref10","unstructured":"\u0427\u0430\u0437\u043e\u0432 \u0415.\u0418. \u0410\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u043d\u0430\u044f \u0438 \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f. \u0412 \u043a\u043d.: \u041e\u0441\u0442\u0440\u044b\u0439 \u0438\u043d\u0444\u0430\u0440\u043a\u0442 \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430. \u041c., 1969."},{"key":"ref11","unstructured":"\u0427\u0430\u0437\u043e\u0432 \u0415.\u0418., \u041b\u0430\u043a\u0438\u043d \u041a.\u041c. \u0410\u043d\u0442\u0438\u043a\u043e\u0430\u0433\u0443\u043b\u044f\u043d\u0442\u044b \u0438 \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u0430. \u041c.: \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430, 1977."},{"key":"ref12","unstructured":"\u0427\u0430\u0437\u043e\u0432 \u0415.\u0418., \u041c\u0430\u0442\u0432\u0435\u0435\u0432\u0430 \u041b.\u0421., \u041c\u0430\u0437\u0430\u0435\u0432 \u0410.\u0412., \u0421\u0430\u0440\u0433\u0438\u043d \u041a.\u0415., \u0421\u0430\u0434\u043e\u0432\u0441\u043a\u0430\u044f \u0413.\u0412., \u0420\u0443\u0434\u0430 \u041c.\u042f. \u0412\u043d\u0443\u0442\u0440\u0438\u043a\u043e\u0440\u043e\u043d\u0430\u0440\u043d\u043e\u0435 \u0432\u0432\u0435\u0434\u0435\u043d\u0438\u0435 \u0444\u0438\u0431\u0440\u0438\u043d\u043e\u043b\u0438\u0437\u0438\u043d\u0430 \u043f\u0440\u0438 \u043e\u0441\u0442\u0440\u043e\u043c \u0438\u043d\u0444\u0430\u0440\u043a\u0442\u0435 \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430. \u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0440\u0445\u0438\u0432. 1976,48(4):8-19."},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"De Wood M.A, Spores J, Notske R, et al. Prevalence of total coronary occlusion during the early hours of transmural MI. N Engl J Med. 1980,303:897.","DOI":"10.1056\/NEJM198010163031601"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Rentrop K.P, Blanke H, Karsch K.R, et al. Intracoronary application of nitroglycerin and SK. Clin Cardiol. 1979,(1):354.","DOI":"10.1002\/clc.4960020507"},{"key":"ref15","unstructured":"Gruppo Italiano per lo Studio della Streptochinasi nell\u2019Infarto Miocardica (GISSI): Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet. 1986,(1):397-402."},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Gruppo Italiano per lo Studio della Streptochinasi nell\u2019Infarto Miocardica (GISSI): Long - term effects of intravenous thrombolysis in acute myocardial infarction: final report of the GISSI study. Lancet. 1987;(2):871.","DOI":"10.1016\/S0140-6736(87)91369-9"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both or neither among 17, 187 cases of suspected acute myocardial infarction: ISIS-2. Lancet. 1988;(2):349-60.","DOI":"10.1016\/S0140-6736(88)92833-4"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Lewis H.D, Davis J.W, Archibald D.G, et al. Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of Veterans Administration Cooperative Study. N Engl J Med. 1983;309:396-403.","DOI":"10.1056\/NEJM198308183090703"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Cairns J.A, Gent M, Singer J, et al. Aspirin, sulfinpyrasone, or both in unstable angina. Results of Canadian multicenter trial. N Engl J Med. 1985,313:1369-75.","DOI":"10.1056\/NEJM198511283132201"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Th\u00e9roux P, Ouimet H, Mc Cans J, Latour J.G, Joly P, L\u00e9vy G, Pelletier E, Juneau M, Stasiak J, de Guise P, et al. Aspirin, heparin, or both to treat acute unstable angina. N Engl J Med. 1988,319:1105-11.","DOI":"10.1056\/NEJM198810273191701"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Risk of myocardial infarction and death during traetment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. The RISK Group. Lancet. 1990,336:827-30.","DOI":"10.1016\/0140-6736(90)92336-G"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet. 1996 Nov 16;348(9038):1329-39.","DOI":"10.1016\/S0140-6736(96)09457-3"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010746"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Mehta S.R, Yusuf S, Peters R.J, Bertrand M.E, Lewis B.S, Natarajan M.K, Malmberg K, Rupprecht H, Zhao F, Chrolavicius S, Copland I, Fox K.A; Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators. Effects of pretreatment with clopidogrel and aspirin followed by long - term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;328:527-33.","DOI":"10.1016\/S0140-6736(01)05701-4"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Borja J, Garc\u00eda O, Donado E, Izquierdo I. Clopidogrel and metoprolol in myocardial infarction. Lancet. 2006 Mar 11;367(9513):811-2.","DOI":"10.1016\/S0140-6736(06)68327-X"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Antman E.M, Anbe D.T, Armstrong P.W, Bates E.R, Green L.A, Hand M, Hochman J.S, Krumholz H.M, Kushner F.G, Lamas G.A, Mullany C.J, Ornato J.P, Pearle D.L, Sloan M.A, Smith S.C. Jr, Alpert J.S, Anderson J.L, Faxon D.P, Fuster V, Gibbons R.J, Gregoratos G, Halperin J.L, Hiratzka L.F, Hunt S.A, Jacobs A.K; American College of Cardiology; American Heart Association Task Force on Practice Guidelines; Canadian Cardiovascular Society. ACC\/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction). Circulation. 2004 Aug 31;110(9):e82-292.","DOI":"10.1161\/01.CIR.0000134791.68010.FA"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.007"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409312"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500857"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Telford A.M, Wilson C. Trial of heparin versus atenolol in prevention of myocardial infarction in intermediate coronary syndrome. Lancet. 1981 Jun 6;1(8232):1225-8.","DOI":"10.1016\/S0140-6736(81)92399-0"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"RISC Group Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. The RISC Group. 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