{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T03:12:46Z","timestamp":1783912366980,"version":"3.55.0"},"reference-count":16,"publisher":"Consilium Medicum","issue":"7","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Myeloproliferative disorders (MPD) are accompanied by a high proportion of thrombotic complications, which may lead to cerebrovascular disease (CVD). Aim. To describe MRI-findings in patients with Ph - negative MPD and evaluate any cerebrovascular disease. Materials and methods. We included 104 patients with Ph - negative MPD (age varied between 20 and 58) with clinical correlates of cerebrovascular pathology. Results. Brain MRI showed post - stroke lesions in 20% of patients (7 hemispheric infarcts due to thrombotic occlusion of one of the large cerebral arteries, 14 - cortical infarcts). 37 patients (36%) had vascular cerebral lesions. Cerebral venous sinus thrombosis occurred in 5 patients - in 7% (n=3) of patients with polycythemia vera and 5% (n=2) - in patients with essential thrombocythemia. The incidence of vascular cerebral lesions was associated with higher levels of the following: erythrocyte, platelet count, fibrinogen, and with the decrease in fibrinolytic activity, as well. Conclusion. The pioneering results of the study include the description and analysis of brain MRI-findings in patients with Ph - negative MPD. The underlying mechanisms of cerebrovascular pathology in these patients are associated with certain blood alterations (particularly, hemorheology) which present a major risk factor.<\/jats:p>","DOI":"10.26442\/00403660.2019.07.000329","type":"journal-article","created":{"date-parts":[[2019,8,4]],"date-time":"2019-08-04T22:18:01Z","timestamp":1564957081000},"page":"29-34","source":"Crossref","is-referenced-by-count":4,"title":["Brain MRI-findings in Ph - negative myeloproliferative disorders"],"prefix":"10.26442","volume":"91","author":[{"given":"M M","family":"Tanashyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A L","family":"Melikyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P I","family":"Kuznetsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A A","family":"Raskurazhev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A A","family":"Shabalina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R N","family":"Konovalov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18344","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"key":"ref1","unstructured":"\u041f\u0438\u0440\u0430\u0434\u043e\u0432 \u041c.\u0410., \u0422\u0430\u043d\u0430\u0448\u044f\u043d \u041c.\u041c., \u041c\u0430\u043a\u0441\u0438\u043c\u043e\u0432\u0430 \u041c.\u042e. \u0418\u043d\u0441\u0443\u043b\u044c\u0442: \u0441\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044f. (3-\u0435 \u0438\u0437\u0434\u0430\u043d\u0438\u0435). - \u041c.: \u041c\u0415\u0414\u043f\u0440\u0435\u0441\u0441 - \u0438\u043d\u0444\u043e\u0440\u043c, 2018: 360 \u0441."},{"key":"ref2","unstructured":"Lim H.Y, Ng C, Rigano J, Nandurkar H, Ho P. Utility of global coagulation assays in myeloproliferative neoplasm: thromboelastography, thrombin generation and overall haemostatic potential. Blood. 2017;130:4198."},{"key":"ref3","unstructured":"\u041c\u0435\u043b\u0438\u043a\u044f\u043d \u0410.\u041b., \u0421\u0443\u0445\u0430\u043d\u043e\u0432\u0430 \u0413.\u0410., \u0421\u0443\u0431\u043e\u0440\u0446\u0435\u0432\u0430 \u0418.\u041d. \u0422\u0440\u043e\u043c\u0431\u043e\u0433\u0435\u043c\u043e\u0440\u0440\u0430\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043e\u0441\u043b\u043e\u0436\u043d\u0435\u043d\u0438\u044f \u0438 \u0438\u0445 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u044d\u0441\u0441\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0442\u0440\u043e\u043c\u0431\u043e\u0446\u0438\u0442\u0435\u043c\u0438\u0435\u0439. \u0412\u0435\u0441\u0442\u043d\u0438\u043a \u043f\u043e\u0441\u043b\u0435\u0434\u0438\u043f\u043b\u043e\u043c\u043d\u043e\u0433\u043e \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0433\u043e \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044f. 2013;3:63."},{"key":"ref4","unstructured":"\u041c\u0435\u043b\u0438\u043a\u044f\u043d \u0410.\u041b., \u0422\u0443\u0440\u043a\u0438\u043d\u0430 \u0410.\u0413., \u0410\u0431\u0434\u0443\u043b\u043a\u0430\u0434\u044b\u0440\u043e\u0432 \u041a.\u041c., \u0417\u0430\u0440\u0438\u0446\u043a\u0438\u0439 \u0410.\u042e., \u0410\u0444\u0430\u043d\u0430\u0441\u044c\u0435\u0432 \u0411.\u0412., \u0428\u0443\u0432\u0430\u0435\u0432 \u0412.\u0410. \u0413\u0440\u0438\u0446\u0430\u0435\u0432 \u0421.\u0412., \u041c\u0430\u0440\u0442\u044b\u043d\u043a\u0435\u0432\u0438\u0447 \u0418.\u0421., \u0410\u0444\u0430\u043d\u0430\u0441\u044c\u0435\u0432 \u0411.\u0412., \u041c\u043e\u0440\u043e\u0437\u043e\u0432\u0430 \u0415.\u0412., \u0411\u0430\u0439\u043a\u043e\u0432 \u0412.\u0412., \u0413\u043e\u043b\u0435\u043d\u043a\u043e\u0432 \u0410.\u041a., \u0418\u0432\u0430\u043d\u043e\u0432\u0430 \u0412.\u041b., \u041a\u0430\u043f\u043b\u0430\u043d\u043e\u0432 \u041a.\u0414., \u041a\u043e\u043d\u0441\u0442\u0430\u043d\u0442\u0438\u043d\u043e\u0432\u0430 \u0422.\u0421., \u041f\u043e\u0441\u043f\u0435\u043b\u043e\u0432\u0430 \u0422.\u0418., \u0410\u0433\u0435\u0435\u0432\u0430 \u0422.\u0410., \u0428\u0430\u0442\u043e\u0445\u0438\u043d \u042e.\u0412., \u0421\u0430\u0432\u0447\u0435\u043d\u043a\u043e \u0412.\u0413. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u043f\u043e \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u0438 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 Ph - \u043d\u0435\u0433\u0430\u0442\u0438\u0432\u043d\u044b\u0445 \u043c\u0438\u0435\u043b\u043e\u043f\u0440\u043e\u043b\u0438\u0444\u0435\u0440\u0430\u0442\u0438\u0432\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 (\u0438\u0441\u0442\u0438\u043d\u043d\u0430\u044f \u043f\u043e\u043b\u0438\u0446\u0438\u0442\u0435\u043c\u0438\u044f, \u044d\u0441\u0441\u0435\u043d\u0446\u0438\u0430\u043b\u044c\u043d\u0430\u044f \u0442\u0440\u043e\u043c\u0431\u043e\u0446\u0438\u0442\u0435\u043c\u0438\u044f, \u043f\u0435\u0440\u0432\u0438\u0447\u043d\u044b\u0439 \u043c\u0438\u0435\u043b\u043e\u0444\u0438\u0431\u0440\u043e\u0437). \u0413\u0435\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f \u0438 \u0442\u0440\u0430\u043d\u0441\u0444\u0443\u0437\u0438\u043e\u043b\u043e\u0433\u0438\u044f. 2014;59(4):31-56."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4065\/81.2.159"},{"key":"ref7","unstructured":"\u0422\u0430\u043d\u0430\u0448\u044f\u043d \u041c.\u041c., \u041a\u0443\u0437\u043d\u0435\u0446\u043e\u0432\u0430 \u041f.\u0418., \u041b\u0430\u0433\u043e\u0434\u0430 \u041e.\u0412., \u0428\u0430\u0431\u0430\u043b\u0438\u043d\u0430 \u0410.\u0410., \u0421\u0443\u0431\u043e\u0440\u0446\u0435\u0432\u0430 \u0418.\u041d., \u041c\u0435\u043b\u0438\u043a\u044f\u043d \u0410.\u041b. \u041c\u0438\u0435\u043b\u043e\u043f\u0440\u043e\u043b\u0438\u0444\u0435\u0440\u0430\u0442\u0438\u0432\u043d\u044b\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u0438 \u0438\u0448\u0435\u043c\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0438\u043d\u0441\u0443\u043b\u044c\u0442. \u0410\u043d\u043d\u0430\u043b\u044b \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0438 \u044d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u043e\u0439 \u043d\u0435\u0432\u0440\u043e\u043b\u043e\u0433\u0438\u0438. 2014;8(2):41-5."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.6.1318"},{"key":"ref9","unstructured":"\u0421\u0443\u0431\u043e\u0440\u0446\u0435\u0432\u0430 \u0418.\u041d., \u041c\u0435\u043b\u0438\u043a\u044f\u043d \u0410.\u041b., \u041a\u043e\u0432\u0440\u0438\u0433\u0438\u043d\u0430 \u0410.\u041c., \u0421\u0443\u0434\u0430\u0440\u0438\u043a\u043e\u0432 \u0410.\u0411. \u041b\u0430\u0442\u0435\u043d\u0442\u043d\u0430\u044f \u0438\u0441\u0442\u0438\u043d\u043d\u0430\u044f \u043f\u043e\u043b\u0438\u0446\u0438\u0442\u0435\u043c\u0438\u044f. \u0413\u0435\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f \u0438 \u0442\u0440\u0430\u043d\u0441\u0444\u0443\u0437\u0438\u043e\u043b\u043e\u0433\u0438\u044f. 2016; 61(1-S1):72."},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Tanashyan M.M, Kuznetsova P.I, Shabalina A.A, Raskurazhev A.A, Lagoda O.V, Subortseva I.N, Melikyan A.L. Clinical characteristics of cerebrovascular pathology with patients suffering from Ph - negative myeloproliferative disease. Cerebrovasc Dis Extra. 2016;6(3):66-70. https:\/\/doi.org\/10.1159\/0 00448597","DOI":"10.1159\/000448597"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2015.03.009"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Hurford R, Charidimou A, Fox Z, Cipolotti L, Jager R, Werring D.J. MRI-visible perivascular spaces: relationship to cognition and small vessel disease MRI markers in ischaemic stroke and TIA. J Neurol Neurosurg Psychiatry. 2013;85(5):522-5.","DOI":"10.1136\/jnnp-2013-305815"},{"key":"ref13","unstructured":"\u0414\u043e\u0431\u0440\u044b\u043d\u0438\u043d\u0430 \u041b.\u0410., \u0428\u0430\u043c\u043f\u0442\u0438\u0435\u0432\u0430 \u041a.\u0412., \u041a\u0440\u0435\u043c\u043d\u0435\u0432\u0430 \u0415.\u0418. \u041a\u0430\u043b\u0430\u0448\u043d\u0438\u043a\u043e\u0432\u0430 \u041b.\u0410., \u041a\u0440\u043e\u0442\u0435\u043d\u043a\u043e\u0432\u0430 \u041c.\u0412., \u0413\u043d\u0435\u0434\u043e\u0432\u0441\u043a\u0430\u044f \u0415.\u0412., \u0411\u0435\u0440\u0434\u0430\u043b\u0438\u043d \u0410.\u0411. \u0421\u0443\u0442\u043e\u0447\u043d\u044b\u0439 \u043f\u0440\u043e\u0444\u0438\u043b\u044c \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0434\u0430\u0432\u043b\u0435\u043d\u0438\u044f \u0438 \u043c\u0438\u043a\u0440\u043e\u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u043d\u044b\u0435 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0432\u0435\u0449\u0435\u0441\u0442\u0432\u0430 \u0433\u043e\u043b\u043e\u0432\u043d\u043e\u0433\u043e \u043c\u043e\u0437\u0433\u0430 \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0441 \u0446\u0435\u0440\u0435\u0431\u0440\u0430\u043b\u044c\u043d\u043e\u0439 \u043c\u0438\u043a\u0440\u043e\u0430\u043d\u0433\u0438\u043e\u043f\u0430\u0442\u0438\u0435\u0439 \u0438 \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0433\u0438\u043f\u0435\u0440\u0442\u0435\u043d\u0437\u0438\u0435\u0439. \u0410\u043d\u043d\u0430\u043b\u044b \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0438 \u044d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u043e\u0439 \u043d\u0435\u0432\u0440\u043e\u043b\u043e\u0433\u0438\u0438. 2019;13(1):36-46."},{"key":"ref14","unstructured":"\u0412\u0435\u0440\u0435\u0449\u0430\u0433\u0438\u043d \u041d.\u0412., \u041c\u043e\u0440\u0433\u0443\u043d\u043e\u0432 \u0412.\u0410., \u0413\u0443\u043b\u0435\u0432\u0441\u043a\u0430\u044f \u0422.\u0421. \u041f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f \u0433\u043e\u043b\u043e\u0432\u043d\u043e\u0433\u043e \u043c\u043e\u0437\u0433\u0430 \u043f\u0440\u0438 \u0430\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0437\u0435 \u0438 \u0430\u0440\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0433\u0438\u043f\u0435\u0440\u0442\u043e\u043d\u0438\u0438. \u041c.: \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430, 1997."},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Falanga A, Marchetti M, Barbui T, Smith C.W. Pathogenesis of thrombosis in essential thrombocythemia and polycythemia vera: the role of neutrophils. Semin Hematol. 2005;42(4):239-47.","DOI":"10.1053\/j.seminhematol.2005.05.023"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013311"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/33582\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/33582\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T21:39:38Z","timestamp":1634161178000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/33582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,15]]},"references-count":16,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7,15]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2019.07.000329","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7,15]]}}}