{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T22:02:26Z","timestamp":1721858546744},"reference-count":16,"publisher":"Consilium Medicum","issue":"10","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Central hypothyroidism is a rare cause of hypothyroidism, consequence of various disorders affecting pituitary (secondary) or hypothalamus (tertiary hypothyroidism). Difficulties in the diagnosis and management of patients are due to the nontypical clinical picture, frequent combination with impaired function of other pituitary hormones, difficulties in laboratory assessment in high TSH levels or low - normal T4 free levels. Diagnosis is based on a confirmed decrease in the level of free T4 with a low or normal level of TSH. The standard treatment for hypothyroidism of any etiology remains monotherapy with levothyroxine, which allows to restore the euthyroid state in most patients. The criterion for the effectiveness of therapy is to maintain the level of T4 free in the upper half of the reference norm interval. The article presents a modern understanding of epidemiology, pathogenesis and strategies for managing patients with central hypothyroidism.<\/jats:p>","DOI":"10.26442\/00403660.2019.10.000358","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T22:30:51Z","timestamp":1574980251000},"page":"135-138","source":"Crossref","is-referenced-by-count":1,"title":["Central hypothyroidism"],"prefix":"10.26442","volume":"91","author":[{"given":"N A","family":"Petunina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L V","family":"Trukhina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N S","family":"Martirosian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-008-0122-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000491388"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.47"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2531"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Faglia G, Bitensky L, Pinchera A, Ferrari C, Paracchi A, Beck-Peccoz P, Ambrosi B, Spada A. Thyrotropin secretion in patients with central hypothyroidism: evidence for reduced biological activity of immunoreactive thyrotropin. J Clin Endocrinol Metab. 1979;48:989-98.","DOI":"10.1210\/jcem-48-6-989"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3977"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1616"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2009.08.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12868"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Alexopoulou O, Beguin C, De Nayer P, Maiter D. Clinical and hormonal characteristics of central hypothyroidism at diagnosis and during follow - up in adult patients. Eur J Endocrinol. 2004 Jan;150(1):1-8.","DOI":"10.1530\/eje.0.1500001"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Slawik M, Klawitter B, Meiser E, Schories M, Zwermann O, Borm K, Peper M, Lubrich B, Hug M.J, Nauck M, Olschewski M, Beuschlein F, Reincke M. Thyroid hormone replacement for central hypothyroidism: a randomized controlled trial comparing two doses of thyroxine (T4) with a combination of T4 and triiodothyronine. J Clin Endocrinol Metab. 2007 Nov;92(11):4115-22.","DOI":"10.1210\/jc.2007-0297"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000242"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Rajput R, Chatterjee S, Rajput M. Can levothyroxine be taken as evening dose? Comparative evaluation of morning versus evening dose of levothyroxine in treatment of hypothyroidism. J Thyroid Res. 2011;2011:505239.","DOI":"10.4061\/2011\/505239"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Bensenor I.M, Olmos R.D, Lotufo P.A. Hypothyroidism in the elderly: diagnosis and management. Clin Interv Aging. 2012;7:97-111.","DOI":"10.2147\/CIA.S23966"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Koulouri O, Auldin M.A, Agarwal R, Kieffer V, Robertson C, Falconer Smith J, Levy M.J, Howlett T.A. Diagnosis and treatment of hypothyroidism in TSH deficiency compared to primary thyroid disease: pituitary patients are at risk of under - replacement with levothyroxine. Clin Endocrinol. 2011;74:744-9.","DOI":"10.1111\/j.1365-2265.2011.03984.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0130"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/33720\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/33720\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T21:20:38Z","timestamp":1634160038000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/33720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,15]]},"references-count":16,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,15]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2019.10.000358","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10,15]]}}}