{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:21:09Z","timestamp":1792023669594,"version":"4.4.0"},"reference-count":85,"publisher":"Consilium Medicum","issue":"10","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease that combines various clinical manifestations and pathophysiological mechanisms. It underlies the separation of patients with COPD by phenotypes, endotypes and a personalized therapy of this disease. The implementation of this approach is possible only with the use of appropriate biomarkers. One of the most important biomarkers of COPD is eosinophilia of blood and\/or sputum, which is considered as a predictor of frequent exacerbations and the effectiveness of inhaled glucocorticosteroids in patients with COPD. The literature discusses the impact of eosinophilic inflammation on the prognosis, clinical and functional parameters in COPD, and the role of the targeted therapy in the treatment of eosinophilic COPD.<\/jats:p>","DOI":"10.26442\/00403660.2019.10.000426","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T22:30:51Z","timestamp":1574980251000},"page":"144-152","source":"Crossref","is-referenced-by-count":11,"title":["Eosinophilic inflammation in chronic obstructive pulmonary disease"],"prefix":"10.26442","volume":"91","author":[{"given":"S N","family":"Avdeev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N V","family":"Trushenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z M","family":"Merzhoeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M S","family":"Ivanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E V","family":"Kusraeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18344","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.18093\/0869-0189-2017-27-1-13-20"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rppnen.2015.12.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.6.7952628"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-7939-2_2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.5.9804028"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2018.1441275"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00106-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00162414"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/2040622315609251"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.10.002"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-017-9990-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/08958378.2017.1346006"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.01.013"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12724"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000221902"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.4.2790"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.108290"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5603\/ARM.a2017.0045"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-113"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118456"},{"key":"ref22","unstructured":"Brusselle G, Pavord I.D, Landis S, Pascoe S, Lettis S, Morjaria N, Barnes N, Hilton E. Blood eosinophil levels as a biomarker in COPD. Respir Med. 2017. doi: 10.1016\/ j.rmed.2018.03.016"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/all.13760"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201408-1458OC"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70187-0"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-112"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212110"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2016.1139084"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S152291"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201104-0597OC"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202646"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00072105"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S115132"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.14.0226"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13036"},{"key":"ref36","unstructured":"Hastie A.T, Alexis N.E, Doerschuk C, Hansel N.N, Christenson S, Putcha N, et al. Blood eosinophils poorly correlate with sputum eosinophils, and have few associations with spirometry, clinical and quantitated computed tomography measures compared to sputum eosinophils in the SPIROMICS cohort. Am J Respir Crit Care Med. 2016;193:A6168."},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0559-0"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S100338"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201708-1684LE"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201705-0892LE"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201601-0015ED"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0840-x"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201612-2525LE"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01162-2017"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.12.979"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201701-0009LE"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2011.602422"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198101083040201"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Weir M, Zhao H, Han M.K, Kanner R, Pirozzi C.S, Scholand M.B, et al. Eosinophils in chronic obstructive pulmonary disease, the SPIROMICS cohort. Am J Respir Crit Care Med. 2014;189:A5902.","DOI":"10.1164\/rccm.201308-1541PP"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201509-1869OC"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2015.1.92"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S163749"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01659-2015"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-013-9653-8"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S134998"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Lams B.E, Sousa A.R, Rees P.J, Lee T.H. Subepithelial immunopathology of the large airways in smokers with and without chronic obstructive pulmonary disease. Eur Respir J. 2000 Mar;15(3):512-6. PMID: 10759445","DOI":"10.1034\/j.1399-3003.2000.15.14.x"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30432-0"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S80992"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4655"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S94259"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S129787"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S90330"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2009.01651.x"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S88058"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.10.003"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13745-x"},{"key":"ref67","unstructured":"Rahimi-Rada M.H, Asgarib B, Hosseinzadehc N, Eishid A. Eosinopenia as a marker of outcome in acute exacerbations of chronic obstructive pulmonary disease. MAEDICA - J Clin Med. 2015;10(1):10-13."},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S194511"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.3.565"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00146306"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201502-0235LE"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708208"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2018.OA2127"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01370-2015"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30368-0"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201709-1822LE"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201701-0193OC"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-015-0322-6"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.congress-2015.PA4362"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02486-2016"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201500135"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.071068"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201112-2142OC"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1905248"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S94797"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/33724\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/33724\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T21:20:55Z","timestamp":1634160055000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/33724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,15]]},"references-count":85,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10,15]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2019.10.000426","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10,15]]}}}