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The most promising compounds for the development as immunomodulating agents and adjuvants for a wide range of vaccines are low molecular weight fragments of peptidoglycan - muramylpeptides. The article describes the mechanisms of action of muramylpeptides, their biological effects and properties of medicines developed on their basis. Special emphasis is placed to glucosaminylmuramyl dipeptide registered in the Russian Federation under the trade name Likopid, which is currently the best - studied drug in its group. The results of Likopid studies when used as a prophylactic and therapeutic agent for infections of various localization in adults and children, for oncological diseases and complications of chemotherapy and radiation therapy, psoriasis, atopic and other diseases are presented. It is emphasized that in diseases associated with human papillomavirus and plaque psoriasis, according to current criteria of evidence - based medicine, Likopid should be classified as drug with level A efficacy (high efficiency in 80-100% of patients). High safety of Likopid in adults and children, including newborns, is noted.<\/jats:p>","DOI":"10.26442\/00403660.2019.12.000471","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T15:59:34Z","timestamp":1593446374000},"page":"122-127","source":"Crossref","is-referenced-by-count":5,"title":["Muramyldipeptide - based compounds in current medicine: focus on glucosaminylmuramyl dipeptide"],"prefix":"10.26442","volume":"91","author":[{"given":"E A","family":"Ushkalova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S K","family":"Zyryanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K E","family":"Zatolochina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18344","published-online":{"date-parts":[[2019,12,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.02.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000085"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70134-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14436"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14481"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci7110144"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx035"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00002"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2018.02.017"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2018_45"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12878"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glw240"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1265897"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0366-6999.2012.18.023"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-013-4478-0"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.MR0518-204RR"},{"key":"ref18","unstructured":"\u0421\u0430\u043c\u0441\u044b\u0433\u0438\u043d\u0430 \u0413.\u0410., \u0422\u0440\u043e\u0448\u0438\u043d\u0430 \u0412.\u0412., \u041f\u0435\u0440\u0446\u0435\u0432\u0430 \u0410.\u0414. \u041e\u0441\u043e\u0431\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u043e\u0432 \u0432\u0440\u043e\u0436\u0434\u0435\u043d\u043d\u043e\u0433\u043e \u0438 \u0430\u0434\u0430\u043f\u0442\u0438\u0432\u043d\u043e\u0433\u043e \u0438\u043c\u043c\u0443\u043d\u0438\u0442\u0435\u0442\u0430 \u0443 \u0447\u0430\u0441\u0442\u043e \u0431\u043e\u043b\u0435\u044e\u0449\u0438\u0445 \u0434\u0435\u0442\u0435\u0439. \u0412\u0435\u0441\u0442\u043d\u0438\u043a \u0420\u0413\u041c\u0423. 2013;(2):42-6."},{"key":"ref19","unstructured":"\u0425\u0440\u044f\u043d\u0438\u043d \u0410.\u0410. \u041d\u0430\u0448 \u043e\u0442\u0432\u0435\u0442 \u0440\u0435\u0437\u0438\u0441\u0442\u0435\u043d\u0442\u043d\u043e\u0441\u0442\u0438. \u0418\u043c\u043c\u0443\u043d\u043e\u043c\u043e\u0434\u0443\u043b\u0438\u0440\u0443\u044e\u0449\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0439, \u043f\u0435\u0440\u0435\u0434\u0430\u0432\u0430\u0435\u043c\u044b\u0445 \u043f\u043e\u043b\u043e\u0432\u044b\u043c \u043f\u0443\u0442\u0435\u043c, \u0441 \u043f\u043e\u0437\u0438\u0446\u0438\u0438 \u0434\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u044b. 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\u041c\u0430\u043a\u0441\u0438\u043c\u043e\u0432\u0430 \u0422.\u0410. \u0438 \u0434\u0440. \u041e\u043f\u0442\u0438\u043c\u0438\u0437\u0430\u0446\u0438\u044f \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0447\u0430\u0441\u0442\u043e \u0438 \u0434\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u0431\u043e\u043b\u0435\u044e\u0449\u0438\u0445 \u0434\u0435\u0442\u0435\u0439: \u0438\u043c\u043c\u0443\u043d\u043e\u043a\u043e\u0440\u0440\u0435\u043a\u0446\u0438\u044f \u041b\u0438\u043a\u043e\u043f\u0438\u0434\u043e\u043c. \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0439 \u043f\u0435\u0434\u0438\u0430\u0442\u0440\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b. 2001;(5):27-9."},{"key":"ref57","unstructured":"\u041c\u0435\u043d\u0438\u043d\u0433\u043e\u043a\u043e\u043a\u043a\u043e\u0432\u0430\u044f \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044f \u0443 \u0434\u0435\u0442\u0435\u0439 (\u044d\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u044f, \u043a\u043b\u0438\u043d\u0438\u043a\u0430, \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430, \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0438 \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0430). \u041c\u0435\u0442\u043e\u0434\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u043f\u043e\u0434 \u0440\u0435\u0434\u0430\u043a\u0446\u0438\u0435\u0439 \u0437\u0430\u0441\u043b\u0443\u0436\u0435\u043d\u043d\u043e\u0433\u043e \u0434\u0435\u044f\u0442\u0435\u043b\u044f \u043d\u0430\u0443\u043a\u0438 \u0420\u0424, \u043f\u0440\u043e\u0444\u0435\u0441\u0441\u043e\u0440\u0430 \u0430\u043a\u0430\u0434\u0435\u043c\u0438\u043a\u0430 \u0420\u0410\u041c\u041d \u042e.\u0412. \u041b\u043e\u0431\u0437\u0438\u043d\u0430. \u0421\u0430\u043d\u043a\u0442-\u041f\u0435\u0442\u0435\u0440\u0431\u0443\u0440\u0433: \u0418\u0437\u0434\u0430\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u043e \u0422\u0430\u043a\u0442\u0438\u043a-\u0421\u0442\u0443\u0434\u0438\u043e; 2009. \u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e \u043f\u043e \u0441\u0441\u044b\u043b\u043a\u0435: http:\/\/www.licopid.ru\/sites\/default\/files\/meningokokkovaya_infekciya_u_detey_epidemiologiya_klinika_diagnostika_terapiya_i_profilaktika.pdf"},{"key":"ref58","unstructured":"\u0421\u043e\u0431\u043e\u043b\u0435\u0432\u0430 \u041d.\u0413., \u0428\u0430\u043f\u043e\u0432\u0430\u043b\u043e\u0432\u0430 \u0422.\u0418., \u041e\u0441\u0438\u043f\u043e\u0432\u0430 \u0418.\u0413. \u0420\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b \u0434\u0432\u043e\u0439\u043d\u043e\u0433\u043e \u0441\u043b\u0435\u043f\u043e\u0433\u043e \u0440\u0430\u043d\u0434\u043e\u043c\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0433\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u043b\u0438\u043a\u043e\u043f\u0438\u0434\u0430 \u0432 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u043e\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u0438 \u0446\u0438\u0442\u043e\u043c\u0435\u0433\u0430\u043b\u043e\u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0433\u043e \u0433\u0435\u043f\u0430\u0442\u0438\u0442\u0430 \u0443 \u0434\u0435\u0442\u0435\u0439. \u041f\u0435\u0434\u0438\u0430\u0442\u0440\u0438\u044f: \u043d\u0430\u0443\u0447\u043d\u043e - \u043f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b. 2009;87(2):100-3."},{"key":"ref59","unstructured":"\u041c\u0430\u0439\u0447\u0443\u043a \u042e.\u0424. \u0414\u0435\u0441\u044f\u0442\u0438\u043b\u0435\u0442\u043d\u0438\u0439 \u043e\u043f\u044b\u0442 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0438\u043c\u043c\u0443\u043d\u043e\u043c\u043e\u0434\u0443\u043b\u044f\u0442\u043e\u0440\u0430 \u041b\u0438\u043a\u043e\u043f\u0438\u0434\u0430 \u0432 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u0433\u043b\u0430\u0437. \u0420\u0435\u0444\u0440\u0430\u043a\u0446\u0438\u043e\u043d\u043d\u0430\u044f \u0445\u0438\u0440\u0443\u0440\u0433\u0438\u044f \u0438 \u043e\u0444\u0442\u0430\u043b\u044c\u043c\u043e\u043b\u043e\u0433\u0438\u044f. 2005;5(2):52-6."},{"key":"ref60","unstructured":"\u041c\u0430\u0439\u0447\u0443\u043a \u042e.\u0424., \u041f\u043e\u0437\u0434\u043d\u044f\u043a\u043e\u0432 \u0412.\u0418, \u041f\u043e\u0437\u0434\u043d\u044f\u043a\u043e\u0432\u0430 \u0412.\u0412. \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430\u044f \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u044f \u2116\u0424\u0421-2007\/020-\u0443. \u041a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0442\u044f\u0436\u0435\u043b\u044b\u0445 \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u0433\u043b\u0430\u0437 \u0441 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u0435\u043c \u0438\u043c\u043c\u0443\u043d\u043e\u043c\u043e\u0434\u0443\u043b\u044f\u0442\u043e\u0440\u043e\u0432 \u0438 \u0441\u0440\u0435\u0434\u0441\u0442\u0432 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043b\u0435\u0447\u0435\u043d\u0438\u044f. \u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e \u043f\u043e \u0441\u0441\u044b\u043b\u043a\u0435: http:\/\/www.licopid.ru\/sites\/default\/files\/maychukyu.f.kompleksnaya_terapiya_tyazhelyh_vospalitelnyh_zabolevaniy_glaz_s_primeneniem_immunomodulyatorov_i_sredstv_specificheskogo_lecheniya.pdf (\u0434\u0430\u0442\u0430 \u043e\u0431\u0440\u0430\u0449\u0435\u043d\u0438\u044f: 20.08.2019)"},{"key":"ref61","unstructured":"\u041b\u0438\u043a\u043e\u043f\u0438\u0434\u00ae - \u043d\u043e\u0432\u044b\u0435 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u0432 \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0438 \u0441\u0435\u0437\u043e\u043d\u043d\u043e\u0439 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u0435\u043c\u043e\u0441\u0442\u0438 \u0443 \u0434\u0435\u0442\u0435\u0439 \u0438 \u0432\u0437\u0440\u043e\u0441\u043b\u044b\u0445. \u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e \u043f\u043e \u0441\u0441\u044b\u043b\u043a\u0435: http:\/\/www.licopid.ru\/sites\/default\/files\/sbornik_statey_snizhenie_sezonnoy_zabolevaemosti.pdf (\u0434\u0430\u0442\u0430 \u043e\u0431\u0440\u0430\u0449\u0435\u043d\u0438\u044f: 20.08.2019)."},{"key":"ref62","unstructured":"\u041b\u0438\u043a\u043e\u043f\u0438\u0434 \u0432 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u043e\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u0438 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0442\u0443\u0431\u0435\u0440\u043a\u0443\u043b\u0435\u0437\u043e\u043c \u043b\u0435\u0433\u043a\u0438\u0445. \u041f\u043e\u0441\u043e\u0431\u0438\u0435 \u0434\u043b\u044f \u0432\u0440\u0430\u0447\u0435\u0439. \u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e \u043f\u043e \u0441\u0441\u044b\u043b\u043a\u0435: http:\/\/www.licopid.ru\/sites\/default\/files\/ftiziatriya_likopid_v_lechenii_tuberkuleza.pdf (\u0434\u0430\u0442\u0430 \u043e\u0431\u0440\u0430\u0449\u0435\u043d\u0438\u044f: 20.08.2019)."},{"key":"ref63","unstructured":"\u041b\u0438\u043a\u043e\u043f\u0438\u0434\u00ae \u0432 \u043e\u0442\u043e\u0440\u0438\u043d\u043e\u043b\u0430\u0440\u0438\u043d\u0433\u043e\u043b\u043e\u0433\u0438\u0438. \u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e \u043f\u043e \u0441\u0441\u044b\u043b\u043a\u0435: http:\/\/www.licopid.ru\/sites\/default\/files\/likopid_v_otorinolaringologii._ sbornik_nauchnyh_statei.pdf (\u0434\u0430\u0442\u0430 \u043e\u0431\u0440\u0430\u0449\u0435\u043d\u0438\u044f: 20.08.2019)"},{"key":"ref64","unstructured":"\u0410\u043b\u0435\u043a\u0441\u0435\u0435\u0432\u0430 \u0415.\u0418., \u0410\u043d\u0434\u0440\u043e\u043d\u043e\u0432\u0430 \u0422.\u041c., \u0412\u043e\u043b\u043e\u0434\u0438\u043d \u041d.\u041d., \u0414\u0435\u0433\u0442\u044f\u0440\u0435\u0432\u0430 \u041c.\u0412., \u0441\u043e\u0441\u0442\u0430\u0432\u0438\u0442\u0435\u043b\u0438. \u0418\u043c\u043c\u0443\u043d\u043e\u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u043b\u0438\u043a\u043e\u043f\u0438\u0434\u0430 \u0432 \u043f\u0435\u0434\u0438\u0430\u0442\u0440\u0438\u0438: \u041c\u0435\u0442\u043e\u0434\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u043f\u043e\u0441\u043e\u0431\u0438\u0435 \u0434\u043b\u044f \u0432\u0440\u0430\u0447\u0435\u0439. \u041c.: \u041f\u0435\u043f\u0442\u0435\u043a, 2005."},{"key":"ref65","unstructured":"\u041c\u0435\u0442\u043e\u0434\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u211696\/181 \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u0430 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0420\u0424. \u0418\u043c\u043c\u0443\u043d\u043e\u0442\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u043b\u0438\u043a\u043e\u043f\u0438\u0434\u0430 \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0441 \u0432\u0442\u043e\u0440\u0438\u0447\u043d\u044b\u043c\u0438 \u0438\u043c\u043c\u0443\u043d\u043e\u0434\u0435\u0444\u0438\u0446\u0438\u0442\u043d\u044b\u043c\u0438 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u044f\u043c\u0438. \u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e \u043f\u043e \u0441\u0441\u044b\u043b\u043a\u0435: http:\/\/www.licopid.ru\/sites\/default\/files\/metodicheskiye-ukazaniya-1.pdf (\u0434\u0430\u0442\u0430 \u043e\u0431\u0440\u0430\u0449\u0435\u043d\u0438\u044f: 20.08.2019)"},{"key":"ref66","unstructured":"\u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u044b\u0435 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u043f\u043e \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044e \u0442\u0443\u0431\u0435\u0440\u043a\u0443\u043b\u0435\u0437\u0430 \u043e\u0440\u0433\u0430\u043d\u043e\u0432 \u0434\u044b\u0445\u0430\u043d\u0438\u044f. \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0435 \u043e\u0431\u0449\u0435\u0441\u0442\u0432\u043e \u0444\u0442\u0438\u0437\u0438\u0430\u0442\u0440\u043e\u0432. \u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e \u043f\u043e \u0441\u0441\u044b\u043b\u043a\u0435: http:\/\/obltub.ru\/images\/153\/2\/protokol1.pdf (\u0434\u0430\u0442\u0430 \u043e\u0431\u0440\u0430\u0449\u0435\u043d\u0438\u044f: 20.08.2019)"},{"key":"ref67","unstructured":"\u041b\u0438\u043a\u043e\u043f\u0438\u0434 \u0432 \u043b\u0435\u0447\u0435\u043d\u0438\u0438 \u0433\u0438\u043d\u0435\u043a\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439. \u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e \u043f\u043e \u0441\u0441\u044b\u043b\u043a\u0435: www.licopid.ru\/sites\/default\/files\/likopid_v_lechenii_ginekologicheskih_zabolevaniy.pdf (\u0434\u0430\u0442\u0430 \u043e\u0431\u0440\u0430\u0449\u0435\u043d\u0438\u044f: 20.08.2019)"},{"key":"ref68","unstructured":"\u0425\u0440\u044f\u043d\u0438\u043d \u0410.\u0410. \u0412\u0417\u041e\u041c\u0422: \u0441\u0442\u0440\u0430\u0442\u0435\u0433\u0438\u044f \u0434\u043e\u0441\u0442\u0438\u0436\u0435\u043d\u0438\u044f \u0434\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0440\u0435\u043c\u0438\u0441\u0441\u0438\u0438 \u0438 \u0440\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0439 \u043f\u043e\u0434\u0445\u043e\u0434 \u043a \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u043e\u0441\u0442\u0440\u044b\u0445 \u0438 \u043e\u0431\u043e\u0441\u0442\u0440\u0438\u0432\u0448\u0438\u0445\u0441\u044f \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u043e\u0432. StatusPraesens. 2016;3(32):2-11. \u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e \u043f\u043e \u0441\u0441\u044b\u043b\u043a\u0435: http:\/\/www.licopid.ru\/sites\/default\/files\/docs\/Hryanin-terapiya-ostryh-processov.pdf"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.25207\/1608-6228-2017-24-5-120-128"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.15789\/1563-0625-2007-4-5-435-446"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)79253-9"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01275"},{"key":"ref73","unstructured":"\u0420\u0435\u0432\u044f\u043a\u0438\u043d\u0430 \u0412.\u0410., \u041a\u043e\u0437\u043b\u043e\u0432\u0430 \u0418.\u0413., \u0412\u043e\u0440\u043e\u043d\u0438\u043d\u0430 \u0415.\u0412. \u0438 \u0434\u0440. \u0412\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u0433\u043b\u044e\u043a\u043e\u0437\u0430\u043c\u0438\u043d\u0438\u043b\u043c\u0443\u0440\u0430\u043c\u0438\u043b\u0434\u0438\u043f\u0435\u043f\u0442\u0438\u0434\u0430 \u0432 \u043b\u0435\u0447\u0435\u043d\u0438\u0438 \u0430\u0442\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u0443 \u0434\u0435\u0442\u0435\u0439. \u0412\u043e\u043f\u0440\u043e\u0441\u044b \u043f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043f\u0435\u0434\u0438\u0430\u0442\u0440\u0438\u0438. 2009;4(4):42-9."},{"key":"ref74","unstructured":"\u041a\u043e\u043b\u0435\u0441\u043d\u0438\u043a\u043e\u0432a \u041d.\u0412., \u0410\u043d\u0434\u0440\u043e\u043d\u043e\u0432a \u0422.\u041c., \u0440\u0435\u0434. \u041b\u0438\u043a\u043e\u043f\u0438\u0434 \u0432 \u0430\u043b\u043b\u0435\u0440\u0433\u043e\u043b\u043e\u0433\u0438\u0438: \u0441\u0431\u043e\u0440\u043d\u0438\u043a \u043d\u0430\u0443\u0447\u043d\u044b\u0445 \u0441\u0442\u0430\u0442\u0435\u0439. \u041c.: \u041f\u0435\u043f\u0442\u0435\u043a, 2019. \u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e \u043f\u043e \u0441\u0441\u044b\u043b\u043a\u0435: http:\/\/www.licopid.ru\/sites\/default\/files\/alergologia.pdf"},{"key":"ref75","unstructured":"\u041a\u043e\u0437\u043b\u043e\u0432 \u0418.\u0413., \u0412\u043e\u0440\u043e\u043d\u0438\u043d\u0430 \u0415.\u0412., \u0412\u0430\u043b\u044f\u043a\u0438\u043d\u0430 \u0422.\u0418., \u0421\u0438\u043c\u043e\u043d\u043e\u0432\u0430 \u041c.\u0410., \u0413\u0443\u0440\u044c\u044f\u043d\u043e\u0432\u0430 \u0421.\u0412., \u041c\u0435\u0449\u0435\u0440\u044f\u043a\u043e\u0432\u0430 \u0415.\u0410., \u0410\u043d\u0434\u0440\u043e\u043d\u043e\u0432\u0430 \u0422.\u041c. \u041b\u0438\u043a\u043e\u043f\u0438\u0434 \u0432 \u0438\u043c\u043c\u0443\u043d\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0439: \u043e\u0431\u0437\u043e\u0440 \u044d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u044b\u0445 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0439. \u0412\u043e\u043f\u0440\u043e\u0441\u044b \u0433\u0435\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438\/\u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u0438\u043c\u043c\u0443\u043d\u043e\u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438 \u0432 \u043f\u0435\u0434\u0438\u0430\u0442\u0440\u0438\u0438. 2011;10(2):32-8."},{"key":"ref76","unstructured":"\u041b\u0438\u043a\u043e\u043f\u0438\u0434 \u0432 \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0438. \u0421\u0431\u043e\u0440\u043d\u0438\u043a \u043d\u0430\u0443\u0447\u043d\u044b\u0445 \u0441\u0442\u0430\u0442\u0435\u0439. \u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e \u043f\u043e \u0441\u0441\u044b\u043b\u043a\u0435: http:\/\/www.licopid.ru\/sites\/default\/files\/likopid_v_onko_14.pdf (\u0434\u0430\u0442\u0430 \u043e\u0431\u0440\u0430\u0449\u0435\u043d\u0438\u044f: 20.08.2019)"},{"key":"ref77","unstructured":"\u0413\u0430\u0439\u0441\u0438\u043d\u0430 \u042d.\u0428., \u0414\u0443\u0434\u0430\u0440\u0435\u0432 \u041c.\u0412., \u0427\u0443\u0447\u043a\u043e\u0432\u0430 H.H. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u043e\u0442\u0435\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0438\u043c\u043c\u0443\u043d\u043e\u043c\u043e\u0434\u0443\u043b\u044f\u0442\u043e\u0440\u0430 \u0433\u043b\u044e\u043a\u043e\u0437\u0430\u043c\u0438\u043d\u0438\u043b\u043c\u0443\u0440\u0430\u043c\u0438\u043b - \u0434\u0438\u043f\u0435\u043f\u0442\u0438\u0434\u0430 (\u041b\u0438\u043a\u043e\u043f\u0438\u0434) \u0432 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u043f\u043e\u0436\u0438\u043b\u044b\u0445 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0439 \u0441\u0442\u0435\u043d\u043e\u043a\u0430\u0440\u0434\u0438\u0435\u0439. \u041f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430. 2011;52(4):80-5"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/33756\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/33756\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T21:08:53Z","timestamp":1634159333000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/33756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,15]]},"references-count":77,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12,15]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2019.12.000471","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12,15]]}}}