{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:10:19Z","timestamp":1765041019488,"version":"3.37.3"},"reference-count":14,"publisher":"Consilium Medicum","issue":"3","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To assess the strength of the respiratory muscles in patients with community-acquired pneumonia (CAP) with varying severity of endogenous intoxication.\r\nMaterials and methods. In the hospital, 78 men aged 1826 years with CAP were examined. \u0421AP was diagnosed in 56 (72%) patients, severe CAP in 22 (28%). The severity of endogenous intoxication was verified using intoxication indices: hematological index of intoxication (HII), leukocyte index of intoxication (LII), nuclear index of intoxication (NII) and Krebs index. Middleweight molecules (MWM) was determined by spectrophotometry in the serum and the concentration of interleukin (IL)-10 and tumor necrosis factor \uf061 (TNF-\uf0e1) by ELISA. The strength of the respiratory muscles was measured on the device Micro RPM (Care Fusion, Great Britain). The maximum expiratory pressure (\u041c\u0415\u0420), inspiratory pressure (MIP) in the oral cavity, the Maximal Rate of Pressure Development (MRPD) during inhalation (MRPDin) and exhalation (MRPDex), and intranasal test (SNIP) were determined. Statistical processing was performed using descriptive statistics, MannWhitney test, correlation and cluster analysis.\r\nResults. Three clusters of endogenous intoxication corresponding to mild, moderate and severe degree were identified. The first cluster was represented only by patients with mild CAP, the second-mild CAP and severe CAP, and the third  severe CAP. Dysfunction of the expiratory respiratory muscles prevailed during the height of the disease in patients with the first cluster, and in the second and third inspiratory, including the diaphragm. The level of actually measured values of MIP and SNIP was 68% and 58% of those due to severe endogenous intoxication. Significant negative correlations were established LII, HII, MWM, TNF-\uf0e1, IL-10 \u0441 MEP, MRPDex, MIP \u0438 SNIP. Respiratory muscle dysfunction remained only expiratory respiratory muscles in convalescents of the first cluster, and expiratory and inspiratory muscles of the second and third cluster.\r\nConclusion. The development of respiratory muscle dysfunction in CAP is associated with the influence of endogenous intoxication factors. The results can be used in personalized programs of rehabilitation.<\/jats:p>","DOI":"10.26442\/00403660.2020.03.000372","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T14:35:20Z","timestamp":1593441320000},"page":"19-24","source":"Crossref","is-referenced-by-count":5,"title":["Comparative analysis of the strength of the respiratory muscles in community-acquired pneumonia with different severity of endogenous intoxication"],"prefix":"10.26442","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9250-557X","authenticated-orcid":false,"given":"B. I.","family":"Geltser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2626-412X","authenticated-orcid":false,"given":"A. A.","family":"Dej","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1926-5274","authenticated-orcid":false,"given":"I. N.","family":"Titorenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5830-1322","authenticated-orcid":false,"given":"V. N.","family":"Kotelnikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"ref1","unstructured":"\u0411\u043e\u0440\u043e\u0434\u0438\u043d \u0415.\u0410., \u0415\u0433\u043e\u0440\u0448\u0438\u043d\u0430 \u0415.\u0412., \u0421\u0430\u043c\u0441\u043e\u043d\u043e\u0432 \u0412.\u041f. \u0411\u0438\u043e\u0445\u0438\u043c\u0438\u044f \u044d\u043d\u0434\u043e\u0442\u043e\u043a\u0441\u0438\u043a\u043e\u0437\u0430. \u041c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u044b \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0438 \u043e\u0446\u0435\u043d\u043a\u0430 \u0441\u0442\u0435\u043f\u0435\u043d\u0438 \u0442\u044f\u0436\u0435\u0441\u0442\u0438 \u043f\u0440\u0438 \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445 \u043b\u0435\u0433\u043a\u0438\u0445. \u0411\u043b\u0430\u0433\u043e\u0432\u0435\u0449\u0435\u043d\u0441\u043a: \u0410\u0413\u041c\u0410, 2003 [Borodin EA, Egorshina EV, Samsonov VP. Biochemistry of endotoxemia. Development mechanisms and severity assessment in inflammatory lung diseases. Blagoveshchensk: AGMA, 2003 (In Russ.)]."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.17691\/stm2017.9.2.06"},{"key":"ref3","unstructured":"\u0410\u0432\u0434\u0435\u0435\u0432 \u0421.\u041d. \u041e\u0446\u0435\u043d\u043a\u0430 \u0441\u0438\u043b\u044b \u0434\u044b\u0445\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043c\u044b\u0448\u0446 \u0432 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043f\u0440\u0430\u043a\u0442\u0438\u043a\u0435. \u041f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u044f. 2008;4:2-17 [Avdeev SN. Evaluation of the strength of the respiratory muscles in clinical practice. Prakticheskaya pul\u2019monologiya. 2008;4:2-17 (In Russ.)]."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177723"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-15-123"},{"key":"ref6","unstructured":"\u0413\u0435\u043b\u044c\u0446\u0435\u0440 \u0411.\u0418., \u0414\u0435\u0439 \u0410.\u0410., \u0422\u0438\u0442\u043e\u0440\u0435\u043d\u043a\u043e \u0418.\u041d., \u041a\u043e\u0442\u0435\u043b\u044c\u043d\u0438\u043a\u043e\u0432 \u0412.\u041d. \u041e\u0446\u0435\u043d\u043a\u0430 \u0441\u0438\u043b\u044b \u0434\u044b\u0445\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043c\u044b\u0448\u0446 \u043f\u0440\u0438 \u0432\u043d\u0435\u0431\u043e\u043b\u044c\u043d\u0438\u0447\u043d\u043e\u0439 \u043f\u043d\u0435\u0432\u043c\u043e\u043d\u0438\u0438. \u0412\u043e\u0435\u043d\u043d\u043e-\u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b. 2018;339(11):27-33 [Geltser BI, Day AA, Titorenko IN, Kotelnikov VN. Evaluation of the strength of the respiratory muscles in community-acquired pneumonia. Voenno-medicinskij zhurnal. 2018;339(11):27-33 (In Russ.)]."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.18093\/0869-0189-2014-0-4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7868\/S0869813918090058"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v021.i05"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000580"},{"key":"ref11","unstructured":"\u0410\u043b\u0435\u043a\u0441\u0430\u043d\u0434\u0440\u043e\u0432\u0430 \u041d.\u041f. \u0426\u0438\u0442\u043e\u043a\u0438\u043d\u044b \u0438 \u0440\u0435\u0437\u0438\u0441\u0442\u0438\u0432\u043d\u043e\u0435 \u0434\u044b\u0445\u0430\u043d\u0438\u0435. \u0424\u0438\u0437\u0438\u043e\u043b\u043e\u0433\u0438\u044f \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430. 2012;38(2):119 [Alexandrova NP. Cytokines and Resistive Respiration. Fiziologiya cheloveka. 2012;38(2):119 (In Russ.)]."},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.26442\/00403660.2019.03.000108"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1365283"},{"key":"ref14","unstructured":"\u0422\u0435\u0442\u0435\u043d\u0435\u0432 \u0424.\u0424., \u0410\u0433\u0435\u0435\u0432\u0430 \u0422.\u0421., \u0414\u0430\u043d\u0438\u043b\u0435\u043d\u043a\u043e \u0412.\u042e., \u0414\u0443\u0431\u0430\u043a\u043e\u0432 \u0410.\u0412. \u041f\u0438\u043a\u043e\u0432\u0430\u044f \u0441\u043a\u043e\u0440\u043e\u0441\u0442\u044c \u0432\u044b\u0434\u043e\u0445\u0430 \u0438 \u0431\u0440\u043e\u043d\u0445\u0438\u0430\u043b\u044c\u043d\u043e\u0435 \u0441\u043e\u043f\u0440\u043e\u0442\u0438\u0432\u043b\u0435\u043d\u0438\u0435 \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0432\u043d\u0435\u0431\u043e\u043b\u044c\u043d\u0438\u0447\u043d\u043e\u0439 \u043f\u043d\u0435\u0432\u043c\u043e\u043d\u0438\u0435\u0439. \u0421\u0438\u0431\u0438\u0440\u0441\u043a\u0438\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b. 2005;58(8);43-5 [Tetenev FF, Ageeva TS, Danilenko VYu, Dubakov AV. Peak expiratory flow rate and bronchial resistance in patients with community-acquired pneumonia. Sibirskij medicinskij zhurnal. 2005;58(8);43-5 (In Russ.)]."}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/33888\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/33888\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T20:50:12Z","timestamp":1634158212000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/33888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,27]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,27]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2020.03.000372","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"type":"electronic","value":"2309-5342"},{"type":"print","value":"0040-3660"}],"subject":[],"published":{"date-parts":[[2020,3,27]]}}}