{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T04:33:57Z","timestamp":1667190837533},"reference-count":15,"publisher":"Consilium Medicum","issue":"3","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To assess the risk of exacerbations of bronchial asthma (BA) in smoking patients with the asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) after inpatient treatment. Materials and methods. 36 smokers with ACO (main group) and 36 non-smoking patients (control group) with severe or moderate exacerbation of bronchial asthma were examined. Assessment of the severity of exacerbation of BA before treatment, levels of control and risk of exacerbations of BA after treatment was determined according to the Federal clinical guidelines for the diagnosis and treatment of BA (2016). Spirometry, monitoring of blood oxygenation using transcutaneous spectral pulse oximetry and enzyme immunoassay for determination of matrix metalloproteinases 9 were performed. Smoking experience, smoking index and pack\/years index were taken into account in patients with ACO. The carboxyhaemoglobin level was analyzed by the carbon monoxide fraction in the exhaled air. Results. For the first time in patients with the ACO, the ability of heavy tobacco smoking and associated decrease in blood oxygenation to potentiate the negative impact of other predictors on the risk of exacerbations of the underlying disease was revealed. In smoking patients with the ACO, for the first time, a direct association of higher levels of matrix metalloproteinases 9 (measured before inpatient treatment) with such a predictor of the risk of further exacerbations of the disease as more frequent detection of symptoms of uncontrolled BA was revealed. In non-smoking patients with BA, a direct relationship between increased sputum secretion and eosinophilia of blood and\/or sputum (a predictor of exacerbation of BA) and the relative duration of episodes of decreased blood oxygenation was established. Conclusion. It was found that intensive and prolonged smoking increases the duration and reduces the effectiveness of inpatient treatment of patients with ACO, contributing to the preservation of air traps and low (forced expiratory volume in 1 second 60%) ventilation capacity of the lungs with the persistence of moderately reduced blood oxygenation; the risk of further exacerbations of BA in this phenotype of patients is significantly higher than in non-smoking patients with BA without combination with COPD.<\/jats:p>","DOI":"10.26442\/00403660.2020.03.000422","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T14:35:20Z","timestamp":1593441320000},"page":"25-29","source":"Crossref","is-referenced-by-count":0,"title":["The risk of bronchial asthma exacerbations among smokers with asthma-chronic obstructive pulmonary disease overlap after inpatient treatment"],"prefix":"10.26442","volume":"92","author":[{"given":"V. V.","family":"Gnoevykh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Yu.","family":"Smirnova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu. A.","family":"Shorokhova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. P.","family":"Gening","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. V.","family":"Abakumova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"ref1","unstructured":"\u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u044b\u0435 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u043f\u043e \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044e \u0431\u0440\u043e\u043d\u0445\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0430\u0441\u0442\u043c\u044b, 2016 [Federal clinical guidelines for the diagnosis and treatment of bronchial asthma, 2016 (In Russ.)]. https:\/\/minzdrav.gov-murman.ru\/documents\/poryadki-okazaniya-meditsinskoy- pomoshchi\/clinasthma22013(3).pdf"},{"key":"ref2","unstructured":"Global Initiative for Asthma, GINA. 2018. https:\/\/ginasthma.org\/wp-content\/uploads\/2018\/04\/wms-GINA-2018-report-V1.3-002.pdf"},{"key":"ref3","unstructured":"\u0420\u0435\u0441\u043f\u0438\u0440\u0430\u0442\u043e\u0440\u043d\u0430\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430. \u041f\u043e\u0434 \u0440\u0435\u0434. \u0410.\u0413. \u0427\u0443\u0447\u0430\u043b\u0438\u043d\u0430. 2-\u0435 \u0438\u0437\u0434. \u0422. 1. \u041c.: \u041b\u0438\u0442\u0442\u0435\u0440\u0440\u0430, 2017 [Respiratory medicine. Ed. A.G. Chuchalina. 2nd ed. T. 1. Moscow: Litterra, 2017 (In Russ.)]."},{"key":"ref4","unstructured":"\u0410\u0432\u0434\u0435\u0435\u0432 \u0421.\u0420., \u0410\u0439\u0441\u0430\u043d\u043e\u0432 \u0417.\u0420., \u0410\u0440\u0445\u0438\u043f\u043e\u0432 \u0412.\u0412. \u0438 \u0434\u0440. \u0421\u043e\u0433\u043b\u0430\u0441\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u043f\u043e \u043e\u0431\u043e\u0441\u043d\u043e\u0432\u0430\u043d\u0438\u044e \u0432\u044b\u0431\u043e\u0440\u0430 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0431\u0440\u043e\u043d\u0445\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0430\u0441\u0442\u043c\u044b \u0438 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043e\u0431\u0441\u0442\u0440\u0443\u043a\u0442\u0438\u0432\u043d\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043b\u0435\u0433\u043a\u0438\u0445 \u0441 \u0443\u0447\u0435\u0442\u043e\u043c \u0444\u0435\u043d\u043e\u0442\u0438\u043f\u0430 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u0438 \u0440\u043e\u043b\u0438 \u043c\u0430\u043b\u044b\u0445 \u0434\u044b\u0445\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043f\u0443\u0442\u0435\u0439. \u0410\u0442\u043c\u043e\u0441\u0444\u0435\u0440\u0430. \u041f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u044f \u0438 \u0430\u043b\u043b\u0435\u0440\u0433\u043e\u043b\u043e\u0433\u0438\u044f. 2013;2:15-26 [Agreed recommendations on the rationale for the treatment of bronchial asthma and chronic obstructive pulmonary disease, taking into account the phenotype of the disease and the role of the small respiratory tract. Atmosphere. Pulmonology and allergology. 2013;2:15-26 (In Russ.)]."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072-1439.2014.03.04"},{"key":"ref6","unstructured":"\u041d\u0435\u043d\u0430\u0448\u0435\u0432\u0430 \u041d.\u041c. \u041f\u0435\u0440\u0441\u043e\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0431\u0440\u043e\u043d\u0445\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0430\u0441\u0442\u043c\u044b: \u0440\u0435\u0430\u043b\u0438\u0438 \u0438 \u043f\u0435\u0440\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u044b. \u0410\u0442\u043c\u043e\u0441\u0444\u0435\u0440\u0430. \u041f\u0443\u043b\u044c\u043c\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u044f \u0438 \u0430\u043b\u043b\u0435\u0440\u0433\u043e\u043b\u043e\u0433\u0438\u044f. 2013;4:12-8 [Nenasheva NM. Personalized therapy of bronchial asthma: realities and prospects. Atmosphere. Pulmonology and allergology. 2013;4:12-8 (In Russ.)]."},{"key":"ref7","unstructured":"\u0411\u0435\u043b\u0435\u0432\u0441\u043a\u0438\u0439 \u0410.\u0421., \u0410\u043d\u043e\u0445\u0438\u043d\u0430 \u0422.\u041d. \u0422\u0440\u0443\u0434\u043d\u0430\u044f \u0434\u043b\u044f \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u044f \u0431\u0440\u043e\u043d\u0445\u0438\u0430\u043b\u044c\u043d\u0430\u044f \u0430\u0441\u0442\u043c\u0430: \u0432\u0441\u0435\u0433\u0434\u0430 \u043b\u0438 \u044d\u0442\u043e \u0442\u044f\u0436\u0435\u043b\u0430\u044f \u0444\u043e\u0440\u043c\u0430 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f? \u0410\u0442\u043c\u043e\u0441\u0444\u0435\u0440\u0430. \u0410\u0441\u0442\u043c\u0430 \u0438 \u0430\u043b\u043b\u0435\u0440\u0433\u0438\u044f. 2016;2:31-6 [Belevskij AS, Anohina TN. Difficult to control bronchial asthma: is it always a severe form of the disease? Atmosphere. Asthma and allergies. 2016;2:31-6 (In Russ.)]."},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Lee JH, Haselkorn T, Borish L, et al. Risk factors associated with per-sistent airflow limitation in severe or difficult-to-treat asthma: insights from the TENOR study. Chest. 2007;132(6):1882-9.","DOI":"10.1378\/chest.07-0713"},{"key":"ref9","unstructured":"\u0427\u0443\u0447\u0430\u043b\u0438\u043d \u0410.\u0413. \u0422\u044f\u0436\u0435\u043b\u0430\u044f \u0431\u0440\u043e\u043d\u0445\u0438\u0430\u043b\u044c\u043d\u0430\u044f \u0430\u0441\u0442\u043c\u0430. \u0420\u041c\u0416. 2000;12:482-6 [Chuchalin AG. Severe bronchial asthma. RMZh. 2000;12:482-6 (In Russ.)]."},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"\u0427\u0435\u0440\u043d\u044b\u0448\u0435\u0432\u0430 \u041e.\u0415. \u041c\u0430\u0440\u043a\u0435\u0440\u044b \u0440\u0435\u043c\u043e\u0434\u0435\u043b\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u0434\u044b\u0445\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043f\u0443\u0442\u0435\u0439 \u043f\u0440\u0438 \u0431\u0440\u043e\u043d\u0445\u043e\u043b\u0435\u0433\u043e\u0447\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445. \u0417\u0434\u043e\u0440\u043e\u0432\u044c\u0435 \u0440\u0435\u0431\u0435\u043d\u043a\u0430. 2014;7(58):80-3 [Chernyshova OYe. Markers of airway remodeling in bronchopulmonary diseases. Zdorov\u2019e rebenka. 2014;7(58):80-3 (In Russ.)].","DOI":"10.22141\/2224-0551.7.58.2014.75838"},{"key":"ref11","unstructured":"\u041d\u0435\u043d\u0430\u0440\u0442\u043e\u0432\u0438\u0447 \u0418.\u0410., \u0416\u0435\u0440\u043d\u043e\u0441\u0435\u043a \u0412.\u0424. \u0420\u0435\u043c\u043e\u0434\u0435\u043b\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u0431\u0440\u043e\u043d\u0445\u043e\u0432 \u043f\u0440\u0438 \u0431\u0440\u043e\u043d\u0445\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0430\u0441\u0442\u043c\u0435 \u0438 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u0435\u0433\u043e \u043a\u043e\u0440\u0440\u0435\u043a\u0446\u0438\u0438. \u0420\u0435\u0446\u0435\u043f\u0442. 2010;3(71):77-89 [Nenartovich IA, Zhernosek VF. Remodeling of bronchi during bronchial asthma and possibility of its correction. Recept. 2010;3(71):77-89 (In Russ.)]."},{"key":"ref12","unstructured":"\u042f\u0440\u043c\u043e\u043b\u0438\u043d\u0441\u043a\u0430\u044f \u041c.\u0418., \u041c\u043e\u043b\u043e\u0442\u043a\u043e\u0432 \u0410.\u0421., \u0414\u0435\u043d\u0438\u0441\u043e\u0432\u0430 \u0412.\u041c. \u041c\u0430\u0442\u0440\u0438\u043a\u0441\u043d\u044b\u0435 \u043c\u0435\u0442\u0430\u043b\u043b\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437\u044b \u0438 \u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440\u044b: \u043a\u043b\u0430\u0441\u0441\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u044f, \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c \u0434\u0435\u0439\u0441\u0442\u0432\u0438\u044f. \u0416\u0443\u0440\u043d\u0430\u043b \u0430\u043a\u0443\u0448\u0435\u0440\u0441\u0442\u0432\u0430 \u0438 \u0436\u0435\u043d\u0441\u043a\u0438\u0445 \u0431\u043e\u043b\u0435\u0437\u043d\u0435\u0439. 2012; LXI(\u0412\u044b\u043f.1):113-25 [Yarmolinskaya MI, Molotkov AS, Denisova VM. Matrix metalloproteinases and inhibitors: classification, mechanism of action. Zhurnal akusherstva i zhenskikh boleznei. 2012; LXI(Vyp.1):113-25 (In Russ.)]."},{"key":"ref13","unstructured":"\u0413\u043d\u043e\u0435\u0432\u044b\u0445 \u0412.\u0412., \u0413\u0435\u043d\u0438\u043d\u0433 \u0422.\u041f., \u041f\u043e\u0440\u0442\u043d\u043e\u0432\u0430 \u042e.\u0410. \u0438 \u0434\u0440. \u041c\u0430\u0442\u0440\u0438\u043a\u0441\u043d\u044b\u0435 \u043c\u0435\u0442\u0430\u043b\u043b\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437\u044b \u0438 \u043a\u043b\u0438\u043d\u0438\u043a\u043e-\u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0439 \u0441\u0442\u0430\u0442\u0443\u0441 \u043a\u0443\u0440\u0438\u043b\u044c\u0449\u0438\u043a\u043e\u0432 \u0441 \u043f\u0435\u0440\u0441\u0438\u0441\u0442\u0438\u0440\u0443\u044e\u0449\u0435\u0439 \u0431\u0440\u043e\u043d\u0445\u0438\u0430\u043b\u044c\u043d\u043e\u0439 \u0430\u0441\u0442\u043c\u043e\u0439. \u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0440\u0445\u0438\u0432. 2014;86(8):29-35. [Gnoevykh VV, Gening TP, Portnova JuA. Matrix metalloproteinase, clinical and functional state at bronchial asthma smokers. Therapeutic Archive. 2014;86(8):29-35 (In Russ.)]."},{"key":"ref14","unstructured":"Diagnosis of diseases of chronic airflow limitation: asthma, COPD and asthma-COPD overlap syndrome (ACOS). A joint proect of GINA and GOLD, 2015. https:\/\/goldcopd.org\/asthma-copd-asthma-copd-overlap-syndrome\/"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.17116\/terarkh2017891268-75"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/33889\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/33889\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T20:37:54Z","timestamp":1667162274000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/33889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,27]]},"references-count":15,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,27]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2020.03.000422","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3,27]]}}}