{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:06:55Z","timestamp":1790662015301,"version":"4.1.0"},"reference-count":40,"publisher":"Consilium Medicum","issue":"5","license":[{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Recent studies have shown a high risk of chronic kidney disease and associated cardiovascular complications in patients with rheumatoid arthritis (RA), which determines the prognosis. However, the prevalence of chronic kidney disease (CKD) in RA has not been established in the Russians. Aim. Study was to examine the prevalence, risk factors and histological variants of CKD in RA. Materials and methods. 180 patients with rheumatoid arthritis were observed in the Tareev clinic of nephrology, for the period from 2014 to 2019 years. Age, gender, duration of RA, drug therapy, ESR, CRP, DAS28, renal function, proteinuria, histological variants were analyzed. Of the common population risk factors for CKD arterial hypertension, weight index, serum lipids and glucose levels were also assessed. Results. The prevalence of CKD in RA was 19.7%. Age, presence and stage of arterial hypertension, an increase in body mass index, as well as high rates of disease activity ESR, CRP, DAS28 score and duration of RA were risk factors of CKD in RA. Age, duration of the disease, stage of AH and hypercholesterolemia were risk factors in multifactorial regression analysis. Amyloidosis was the most common histologic pattern (50.0%), followed by chronic glomerulonephritis (30.4%) and tubulo-interstitial nephritis (19.6%). Among chronic glomerulonephritis mesangial glomerulonephritis was the most frequent. Renal amyloidosis was associated with a duration of RA, presence of systemic symptoms and CRP level. An isolated decrease in GFR of less than 60 ml\/min was detected in 31 (36.0%) out of 86 patients. \u0421onclusion. The risk factors for CKD in patients with RA are activity and duration of the disease In addition to common population factors. Amyloidosis was the most common histologic pattern associated with duration of RA and inflammatory proteins levels.<\/jats:p>","DOI":"10.26442\/00403660.2020.05.000604","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T14:05:35Z","timestamp":1593439535000},"page":"55-60","source":"Crossref","is-referenced-by-count":4,"title":["Clinicopatological variants and risk factors for chronic kidney disease in rheumatoid arthritis"],"prefix":"10.26442","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2128-8560","authenticated-orcid":false,"given":"N. V.","family":"Chebotareva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6138-4333","authenticated-orcid":false,"given":"S. V.","family":"Gulyaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9951-126X","authenticated-orcid":false,"given":"T. V.","family":"Androsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5164-4621","authenticated-orcid":false,"given":"E. N.","family":"Popova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8232-3679","authenticated-orcid":false,"given":"D. V.","family":"Gurova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0148-5655","authenticated-orcid":false,"given":"P. I.","family":"Novikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5599-0350","authenticated-orcid":false,"given":"L. Yu.","family":"Milovanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. V.","family":"Moiseev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18344","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.08.010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204021"},{"key":"ref3","unstructured":"\u041d\u0430\u0441\u043e\u043d\u043e\u0432 \u0415.\u041b., \u041a\u0430\u0440\u0430\u0442\u0435\u0435\u0432 \u0414.\u0415., \u0411\u0430\u043b\u0430\u0431\u0430\u043d\u043e\u0432\u0430 \u0420.\u041c. \u0420\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0439 \u0430\u0440\u0442\u0440\u0438\u0442. \u0412 \u043a\u043d.: \u0420\u0435\u0432\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f. \u041d\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0435 \u0440\u0443\u043a\u043e\u0432\u043e\u0434\u0441\u0442\u0432\u043e. \u041f\u043e\u0434. \u0440\u0435\u0434. \u0415.\u041b. \u041d\u0430\u0441\u043e\u043d\u043e\u0432\u0430, \u0412.\u0410. \u041d\u0430\u0441\u043e\u043d\u043e\u0432\u043e\u0439. \u041c.: \u0413\u042d\u041e\u0422\u0410\u0420-\u041c\u0435\u0434\u0438\u0430, 2008; \u0441. 290-331 [Nasonov EL, Karateev DE, Balabanova RM. Rheumatoid arthritis. In: Rheumatology. National Guide. Nasonov EL, Nasonova VA, ed. Moscow: GEOTAR-Media, 2008; p. 290-331 (In Russ.)]."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw315"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3146-4"},{"key":"ref6","unstructured":"\u041e\u0440\u0430\u043d\u0441\u043a\u0438\u0439 \u0421.\u041f. \u0425\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u043e\u0447\u0435\u043a \u043f\u0440\u0438 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u043e\u043c \u0430\u0440\u0442\u0440\u0438\u0442\u0435: \u0430\u0441\u0441\u043e\u0446\u0438\u0430\u0446\u0438\u044f \u0441 \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u043c \u0440\u0438\u0441\u043a\u043e\u043c. \u0424\u0443\u043d\u0434\u0430\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u044b\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f. 2013;12:285-8 [Oranskij SP. Hronicheskaya bolezn pochek pri revmatoidnom artrite: associaciya s serdechno-sosudistym riskom. Fundamentalnye issledovaniya. 2013;12:285-8 (In Russ.)]. http:\/\/www.fundamental-research.ru\/ru\/article\/view?id=33321"},{"key":"ref7","unstructured":"\u0411\u0430\u0442\u044e\u0448\u0438\u043d \u041c.\u041c., \u0412\u044b\u0441\u0442\u0430\u0432\u043a\u0438\u043d\u0430 \u0415.\u0410. \u0424\u0430\u043a\u0442\u043e\u0440\u044b \u0440\u0438\u0441\u043a\u0430 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0438 \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043f\u043e\u0447\u0435\u043a \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u043c \u0430\u0440\u0442\u0440\u0438\u0442\u043e\u043c. \u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u043f\u0440\u043e\u0431\u043b\u0435\u043c\u044b \u043d\u0430\u0443\u043a\u0438 \u0438 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044f. 2011;5 [Batyushin MM, Vystavkina EA. Faktory riska razvitiya i progressirovaniya hronicheskoj bolezni pochek u bolnyh revmatoidnym artritom. Sovremennye problemy nauki i obrazovaniya. 2011;5 (In Russ.)]. http:\/\/www.science-education.ru\/ru\/article\/view?id=4871"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"\u0421\u0430\u0440\u043a\u0438\u0441\u043e\u0432\u0430 \u0418.\u0410., \u0420\u0430\u043c\u0435\u0435\u0432 \u0412.\u0412., \u041a\u043e\u0437\u043b\u043e\u0432\u0441\u043a\u0430\u044f \u041b.\u0412. \u0420\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u0439 \u0430\u0440\u0442\u0440\u0438\u0442 \u043a\u0430\u043a \u043e\u0441\u043d\u043e\u0432\u043d\u0430\u044f \u043f\u0440\u0438\u0447\u0438\u043d\u0430 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0410\u0410-\u0430\u043c\u0438\u043b\u043e\u0438\u0434\u043e\u0437\u0430. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0433\u0435\u0440\u043e\u043d\u0442\u043e\u043b\u043e\u0433\u0438\u044f. 2009;15(2):14-20 [Sarkisova IA, Rameev VV, Kozlovskaya LV. Revmatoidnyj artrit kak osnovnaya prichina razvitiya AA-amiloidoza. Klinicheskaya gerontologiya. 2009;15(2):14-20 (In Russ.)].","DOI":"10.1255\/nirn.1155"},{"key":"ref9","unstructured":"\u0421\u0430\u0440\u043a\u0438\u0441\u043e\u0432\u0430 \u0418.\u0410., \u0420\u0430\u043c\u0435\u0435\u0432 \u0412.\u0412., \u041a\u043e\u0437\u043b\u043e\u0432\u0441\u043a\u0430\u044f \u041b.\u0412. \u0424\u0430\u043a\u0442\u043e\u0440\u044b \u0440\u0438\u0441\u043a\u0430 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0438 \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u0410\u0410-\u0430\u043c\u0438\u043b\u043e\u0438\u0434\u043e\u0437\u0430 \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u043c \u0430\u0440\u0442\u0440\u0438\u0442\u043e\u043c. \u041d\u0435\u0444\u0440\u043e\u043b\u043e\u0433\u0438\u044f \u0438 \u0434\u0438\u0430\u043b\u0438\u0437. 2007;9(3):346 [Sarkisova IA, Rameev VV, Kozlovskaya LV. Faktory` riska razvitiya i progressirovaniya AA-amiloidoza u bolnykh revmatoidnym artritom. Nefrologiya i dializ. 2007;9(3):346 (In Russ.)]."},{"key":"ref10","unstructured":"\u0421\u0430\u0440\u043a\u0438\u0441\u043e\u0432\u0430 \u0418.\u0410., \u0420\u0430\u043c\u0435\u0435\u0432 \u0412.\u0412., \u0412\u0430\u0440\u0448\u0430\u0432\u0441\u043a\u0438\u0439 \u0412.\u0410. \u0438 \u0434\u0440. \u041e\u0441\u043e\u0431\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u0442\u0435\u0447\u0435\u043d\u0438\u044f \u0410\u0410-\u0430\u043c\u0438\u043b\u043e\u0438\u0434\u043e\u0437\u0430 \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u043c \u0430\u0440\u0442\u0440\u0438\u0442\u043e\u043c. \u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0440\u0445\u0438\u0432. 2006; 78(5):31-6 [Sarkisova IA, Rameev VV, Varshavskij VA, et al. Osobennosti techeniya AA-amiloidoza u bol`ny`kh revmatoidny`m artritom. Therapeutic Archive. 2006;78(5):31-6 (In Russ.)]."},{"key":"ref11","unstructured":"G\u00f3is M, Carvalho F, Sousa H, et al. Renal involvement in rheumatoid arthritis: analysis of 53 renal biopsies. Port J Nephrol Hypert. 2017;31(1):25-30."},{"key":"ref12","unstructured":"\u0420\u0435\u0431\u0440\u043e\u0432 \u0410.\u041f., \u0422\u044f\u043f\u043a\u0438\u043d\u0430 \u041c.\u0410., \u0412\u043e\u043b\u043e\u0448\u0438\u043d\u043e\u0432\u0430 \u0415.\u0412. \u0421\u0443\u0431\u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u043f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u0435 \u043f\u043e\u0447\u0435\u043a \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u043c \u0430\u0440\u0442\u0440\u0438\u0442\u043e\u043c. \u041b\u0435\u0447\u0430\u0449\u0438\u0439 \u0432\u0440\u0430\u0447. 2012;4:40-2 [Rebrov AP, Tyapkina MA, Voloshinova EV. Subclinical failure of kidneys in patients with rheumatoid arthritis. Lechashchij vrach. 2012;4:40-2 (In Russ.)]."},{"key":"ref13","unstructured":"\u041a\u0438\u0441\u0435\u043b\u0435\u0432\u0430 \u0410.\u0413., \u041e\u0440\u043b\u043e\u0432\u0430 \u0413.\u041c., \u0411\u0435\u0440\u0434\u043d\u0438\u043a\u043e\u0432\u0430 \u0418.\u0410., \u0424\u0435\u0440\u0435\u0444\u0435\u0440\u043e\u0432\u0430 \u041d.\u041c. \u0425\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u043e\u0447\u0435\u043a \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0440\u0435\u0432\u043c\u0430\u0442\u043e\u0438\u0434\u043d\u044b\u043c \u0430\u0440\u0442\u0440\u0438\u0442\u043e\u043c. \u0421\u0438\u0431\u0438\u0440\u0441\u043a\u0438\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b. 2007;7:90-2 [Kiseleva AG, Orlova GM, Berdnikova IA, Fereferova NM. Chronic kidney disease in rheumatoid arthritis patients. Sibirskij medicinskij zhurnal, 2007;7:90-2 (In Russ.)]."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160225"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.283"},{"key":"ref16","unstructured":"Nakahara C, Kanemoto K, Saito N, et al. C-reactive protein frequently localizes in the kidney in glomerular diseases. Clin Nephrol. 2001;55(5):365-70."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg407"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.42"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken386"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90201.2008"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.9.658"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/546039"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.39"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204078"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.105049"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Salomon MI, Gallo G, Poon TP, et al. The kidney in rheumatoid arthritis. Nephron. 1974;12:297310.","DOI":"10.1159\/000180342"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159\/000182132"},{"key":"ref28","unstructured":"Yoshida A, Morozumi K, Suganuma T, et al. Clinicopathological study of nephropathy in patients with rheumatoid arthritis. Ryumachi. 1991;31:14-21."},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380213"},{"key":"ref30","unstructured":"Nakano M, Ueno M, Nishi S, et al. Analysis of renal pathology and drug history in 158 Japanese patients with rheumatoid arthritis. Clin Nephrol. 1998;50:154-60."},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3109\/s101650200025"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90654-5"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.11.025"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1002\/art.24308"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.023119"},{"key":"ref36","unstructured":"Gonzalez-Gay MA, De Matias JM, Gonzalez-Juanatey C, et al. Anti-tumor necrosis factor-alpha blockade improves insulin resistance in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2006;24(1):83-6."},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2010.549252"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.01.028"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes190"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1002\/art.11163"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/34603\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/34603\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T20:30:50Z","timestamp":1667161850000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/34603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,5]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,6,5]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2020.05.000604","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6,5]]}}}