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Nowadays antiangiogenic agents (which inhibit VEGF like bevacizumab neither VEGFR2 like ramucirumab) are widely used in very different chemotherapeutic regimens in clinical oncology. The signalling pathway VEGF-VEGFR plays a crucial role in supporting of adequate kidney function. Appearance of antiangiogenic drugs led to adverse nephrotoxic effects: arterial hypertension, proteinuria, rarely  nephrotic syndrome, and kidney dysfunction. Various hystological variants of nephropathy are described, however, in most cases, signs of thrombotic microangiopathy of the renal vessels are noted. This literature review discusses mechanisms, clinical and morphological aspects of nephropathy associated with antiangiogenic drugs.<\/jats:p>","DOI":"10.26442\/00403660.2020.06.000672","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T05:28:27Z","timestamp":1594358907000},"page":"93-98","source":"Crossref","is-referenced-by-count":1,"title":["Nephrotoxicity of anti-angiogenesis drugs"],"prefix":"10.26442","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0616-5477","authenticated-orcid":false,"given":"Katerina S.","family":"Grechukhina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2128-8560","authenticated-orcid":false,"given":"Natalia V.","family":"Chebotareva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7647-3942","authenticated-orcid":false,"given":"Tatyana N.","family":"Krasnova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2020,7,9]]},"reference":[{"key":"ref1","unstructured":"\u0421\u0432\u0435\u0442\u043e\u0437\u0430\u0440\u0441\u043a\u0438\u0439 \u041d.\u041b., \u0410\u0440\u0442\u0438\u0444\u0435\u043a\u0441\u043e\u0432\u0430 \u0410.\u0410., \u0421\u0432\u0435\u0442\u043e\u0437\u0430\u0440\u0441\u043a\u0438\u0439 \u0421.\u041d. \u0424\u0430\u043a\u0442\u043e\u0440 \u0440\u043e\u0441\u0442\u0430 \u044d\u043d\u0434\u043e\u0442\u0435\u043b\u0438\u044f \u0441\u043e\u0441\u0443\u0434\u043e\u0432: \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0441\u0432\u043e\u0439\u0441\u0442\u0432\u0430 \u0438 \u043f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 (\u043e\u0431\u0437\u043e\u0440 \u043b\u0438\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u044b). 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