{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:46:41Z","timestamp":1769503601658,"version":"3.49.0"},"reference-count":25,"publisher":"Consilium Medicum","issue":"8","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. Determine the primary antibiotic resistance of Helicobacter pylori (H. pylori) strains isolated from patients living in the European part of the Russian Federation.\r\nMaterials and methods. As part of a clinical laboratory study, from 2015 to 2018, 27 gastrobiopsy samples obtained from H. pylori-infected patients were analyzed. H. pylori infection was verified using a rapid urease test or a 13C-urea breath test. The values of the minimum inhibitory concentration (MIC) of antibiotics were determined by the diffusion method using E-test strips (BioMerieux, France) according to the recommendations of the manufacturer. The sensitivity of the isolates was determined for 6 antibacterial drugs (amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, rifampicin).\r\nResults. According to the data obtained, resistance to amoxicillin was 0%, clarithromycin  11.1%, metronidazole  59.3%, levofloxacin  3.7%, tetracycline  0%, and rifampicin  14.8%. Dual resistance to clarithromycin and metronidazole was recorded in two isolates (7.4%).\r\nConclusion. Thus, the first results of the evaluation of H. pylori antibiotic resistance in the European part of the Russian Federation indicate a low resistance of the microorganism to clarithromycin and quite high to metronidazole.<\/jats:p>","DOI":"10.26442\/00403660.2020.08.000761","type":"journal-article","created":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T05:42:50Z","timestamp":1599889370000},"page":"24-28","source":"Crossref","is-referenced-by-count":8,"title":["Antibiotic resistance of Helicobacter pylori in the European part of the Russian Federation: first results"],"prefix":"10.26442","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6114-564X","authenticated-orcid":false,"given":"I. V.","family":"Maev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4007-7112","authenticated-orcid":false,"given":"D. 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