{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:34:20Z","timestamp":1740180860658,"version":"3.37.3"},"reference-count":25,"publisher":"Consilium Medicum","issue":"8","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To evaluate the frequency of liver fibrosis progression to stage 34 among patients with non-alcoholic fatty liver disease (NAFLD), type 2 diabetes and obesity, to identify predictors of severe liver fibrosis, to propose an algorithm for diagnosing fibrosis in this category of patients.\r\nMaterials and methods. 160 patients with NAFLD, type 2 diabetes mellitus (DM) and obesity and 50 patients with NAFLD without diabetes were comprehensively examined. Patients underwent laboratory examination (clinical blood test, biochemical analysis, immunoglobulins G, M, autoantibody assay, coagulogram), liver ultrasound. All patients underwent determination of the liver fibrosis stage by two methods: the serological test FibroMax and indirect ultrasound elastometry of the liver; 40 patients underwent a liver biopsy. Statistical data processing was performed using the programming language and statistical calculations R: we used correlation analysis, multiple logistic regression method, one-way analysis of variance, multi-factor analysis, the Kruskal-Wallis method, and comparison of the number of patients using the Fisher test.\r\nResults. DM is a risk factor for the liver fibrosis progression in patients with NAFLD. Significant markers of severe fibrosis in this category of patients are increased levels of GGTP, haptoglobin and alpha-2-macroglobulin, lower platelet and prothrombin levels. Obesity and isolated steatosis without steatohepatitis are not markers of severe liver fibrosis at present, but obesity can be considered a risk factor for the progression of fibrosis in the future.\r\nConclusion. All patients with NAFLD in combination with diabetes need screening to detect advanced liver fibrosis: it is advisable to determine the levels of GGTP, haptoglobin and alpha-2-macroglobulin.<\/jats:p>","DOI":"10.26442\/00403660.2020.08.000770","type":"journal-article","created":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T05:42:50Z","timestamp":1599889370000},"page":"73-78","source":"Crossref","is-referenced-by-count":3,"title":["Non-alcoholic fatty liver disease and type 2 diabetes mellitus: issues of the liver fibrosis diagnostics"],"prefix":"10.26442","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-0712","authenticated-orcid":false,"given":"A. V.","family":"Anisonyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4291-812X","authenticated-orcid":false,"given":"Yu. 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Atlas of health in Europe\/2nd edition. 2008."},{"key":"ref3","unstructured":"\u0414\u0440\u0430\u043f\u043a\u0438\u043d\u0430 \u041e.\u041c., \u0418\u0432\u0430\u0448\u043a\u0438\u043d \u0412.\u0422. \u042d\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u043d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u043e\u0439 \u0436\u0438\u0440\u043e\u0432\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043f\u0435\u0447\u0435\u043d\u0438 \u0432 \u0420\u043e\u0441\u0441\u0438\u0438 (\u0420\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b \u043e\u0442\u043a\u0440\u044b\u0442\u043e\u0433\u043e \u043c\u043d\u043e\u0433\u043e\u0446\u0435\u043d\u0442\u0440\u043e\u0432\u043e\u0433\u043e \u043f\u0440\u043e\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0433\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f-\u043d\u0430\u0431\u043b\u044e\u0434\u0435\u043d\u0438\u044f DIREG L 01903). \u0420\u043e\u0441. \u0436\u0443\u0440\u043d. \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0438, \u0433\u0435\u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438, \u043a\u043e\u043b\u043e\u043f\u0440\u043e\u043a\u0442\u043e\u043b\u043e\u0433\u0438\u0438. 2014;24(4):32-8 [Drapkina OM, Ivashkin VT. Epidemiological features of non-alcoholic fatty liver disease in Russia. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2014;24(4):32-8 (In Russ.)]."},{"key":"ref4","unstructured":"International Diabetes Federation: IDF Diabetes Atlas: Key Messages. http:\/\/diabetesatlas.org\/key-messages.html."},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"\u0414\u0435\u0434\u043e\u0432 \u0418.\u0418., \u0428\u0435\u0441\u0442\u0430\u043a\u043e\u0432\u0430 \u041c.\u0412., \u0412\u0438\u043a\u0443\u043b\u043e\u0432\u0430 \u041e.\u041a. \u042d\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u044f \u0441\u0430\u0445\u0430\u0440\u043d\u043e\u0433\u043e \u0434\u0438\u0430\u0431\u0435\u0442\u0430 \u0432 \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438: \u043a\u043b\u0438\u043d\u0438\u043a\u043e-\u0441\u0442\u0430\u0442\u0438\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u043d\u0430\u043b\u0438\u0437 \u043f\u043e \u0434\u0430\u043d\u043d\u044b\u043c \u0444\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0430 \u0441\u0430\u0445\u0430\u0440\u043d\u043e\u0433\u043e \u0434\u0438\u0430\u0431\u0435\u0442\u0430. \u0421\u0430\u0445\u0430\u0440\u043d\u044b\u0439 \u0434\u0438\u0430\u0431\u0435\u0442. 2017;20(1):13-41. [Dedov II, Shestakova MV, Vikulova OK. Epidemiology of Diabetes Mellitus in Russian Federation: Clinical and Statistical report according to the Federal Diabetes Register. 2017;20(1):13-41 (In Russ.)].","DOI":"10.14341\/DM8664"},{"key":"ref6","unstructured":"\u041c\u0435\u0445\u0442\u0438\u0435\u0432 \u0421.\u041d., \u0413\u0440\u0438\u043d\u0435\u0432\u0438\u0447 \u0412.\u0411., \u041a\u0440\u0430\u0432\u0447\u0443\u043a \u042e.\u0410., \u0411\u0440\u0430\u0449\u0435\u043d\u043a\u043e\u0432\u0430 \u0410.\u0412. \u041d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u0430\u044f \u0436\u0438\u0440\u043e\u0432\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u0435\u0447\u0435\u043d\u0438: \u043a\u043b\u0438\u043d\u0438\u043a\u0430, \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u0435. \u041b\u0435\u0447\u0430\u0449\u0438\u0439 \u0432\u0440\u0430\u0447. 2008;2:29-37. [Mekhtiev SN, Grinevich VB, Kravchuk YuA, Brashchenkova AV. Non-alcoholic fatty liver disease: clinical picture, diagnosis and treatment. Lechaschi Vrach. 2008;2:29-37 (In Russ.)]."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-010-0122-6"},{"key":"ref8","unstructured":"Pazhanivel M, Jayanthi V. Diabetes mellitus and cirrhosis liver. Gastroenterol Dietol. 2010;56(1):7-11."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-313884"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.147"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2016.07.003"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28370"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2012.02.007"},{"key":"ref15","unstructured":"\u0421\u0430\u0445\u0430\u0440\u043d\u044b\u0439 \u0434\u0438\u0430\u0431\u0435\u0442 \u0442\u0438\u043f\u0430 2: \u043e\u0442 \u0442\u0435\u043e\u0440\u0438\u0438 \u043a \u043f\u0440\u0430\u043a\u0442\u0438\u043a\u0435. \u041f\u043e\u0434 \u0440\u0435\u0434. \u0418.\u0418. \u0414\u0435\u0434\u043e\u0432\u0430, \u041c.\u0412. \u0428\u0435\u0441\u0442\u0430\u043a\u043e\u0432\u043e\u0439. \u041c.: \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0435 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u043e\u043d\u043d\u043e\u0435 \u0430\u0433\u0435\u043d\u0442\u0441\u0442\u0432\u043e, 2016. [Diabetes mellitus type 2: from theory to practice. Ed. II Dedova, MV Shestakova. Moscow: Medical Information Agency, 2016 (In Russ.)]."},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012356"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Amarapurka D, Amarapurkar A, Patel N, et al. Nonalcoholic steatohepatitis (NASH) with diabetes: predictors of liver fibrosis. Ann Hepatol. 2006;5(1):30-3.","DOI":"10.1016\/S1665-2681(19)32036-8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04929.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.11.004"},{"key":"ref20","unstructured":"\u041f\u043b\u043e\u0445\u0438\u043d\u0441\u043a\u0438\u0439 \u041d.\u0410. \u0411\u0438\u043e\u043c\u0435\u0442\u0440\u0438\u044f. 2-\u0435 \u0438\u0437\u0434. \u041c.: \u0418\u0437\u0434-\u0432\u043e \u041c\u0413\u0423, 1970; \u0441. 367 [Plokhinsky NA. Biometrics. 2nd ed. Moscow: Moscow State University Publishing House, 1970; p. 367 (In Russ.)]."},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30081-4"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14734"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.endinu.2017.12.011"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.252.lsf"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14577"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/43544\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/43544\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T20:35:50Z","timestamp":1634157350000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/43544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,3]]},"references-count":25,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,9,3]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2020.08.000770","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"type":"electronic","value":"2309-5342"},{"type":"print","value":"0040-3660"}],"subject":[],"published":{"date-parts":[[2020,9,3]]}}}