{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:34:23Z","timestamp":1740180863345,"version":"3.37.3"},"reference-count":30,"publisher":"Consilium Medicum","issue":"10","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim.The purpose of the study is to increase the effectiveness of treatment of metabolic syndrome (MS) in young patients with vitamin D deficiency.\r\nMaterials and methods.The study involved 54 patients with MS and vitamin D deficiency (50% of women, 50% of men), aged 2044years. To assess the concentration of melatonin at a young age, a control group of 42 practically healthy volunteers with comparable demographic characteristics with no signs of MS was formed.\r\nResults.In patients with MS and vitamin D deficiency, there was a significant decrease in the average daily level of 6-sulfatoxymelatonin in the urine by 3.7 times, compared with the group of individuals without MS. Patients with MS and vitamin D deficiency (n=54) were randomly assigned to two groups with comparable clinical and demographic characteristics. Patients of the 1st group (n=27) observed dietary recommendations and took the drug Metformin at a dose of 1700 mg\/day for 12 months. In the 2nd group (n=27), in addition to the one indicated in the 1st treatment group, correction of vitamin D deficiency was performed (a micelled preparation of cholecalciferol at a dose of 4000 IU\/day, for 6 months, then 2000 IU\/day for another 6 months) and the level of melatonin (melatonin preparation at a dose of 3 mg\/day for 6 months). After treatment in young patients with MS, there was a significant change in the median of the studied parameters in all therapeutic groups, but more pronounced dynamics was observed in group 2 in terms of: WC in women, BMI, insulin resistance index, LDL cholesterol, TG, hs-CRP, hs-TNF-, IL-6, leptin.\r\nConclusion.To increase the effectiveness of MS treatment in young patients with vitamin D deficiency, it is necessary to determine the level of melatonin (urinary 6-sulfatoxymelatonin) and, if it decreases, carry out correction of melatonin and 25 (OH) vitamin D in addition to the standard therapy of this syndrome.<\/jats:p>","DOI":"10.26442\/00403660.2020.10.000370","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T05:44:14Z","timestamp":1606196654000},"page":"34-39","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of metabolic syndrome in young patients with vitamin D deficiency"],"prefix":"10.26442","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9122-1735","authenticated-orcid":false,"given":"N. S.","family":"Alekseeva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.14341\/omet2014132-37"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.15829\/1560-4071-2018-5-7-14"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.18565\/cardio.2017.2.46-51"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.17116\/terarkh2016881051-56"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4936-x"},{"key":"ref6","unstructured":"\u041c\u043a\u0440\u0442\u0443\u043c\u044f\u043d \u0410.\u041c., \u041c\u0430\u0440\u043a\u043e\u0432\u0430 \u0422.\u041d., \u041a\u0438\u0447\u0438\u0433\u0438\u043d \u0412.\u0410. \u0438 \u0434\u0440. \u042d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u043c\u0435\u0442\u0444\u043e\u0440\u043c\u0438\u043d\u0430 \u043f\u0440\u0438 \u0430\u0431\u0434\u043e\u043c\u0438\u043d\u0430\u043b\u044c\u043d\u043e\u043c \u043e\u0436\u0438\u0440\u0435\u043d\u0438\u0438. \u0422\u0435\u0440\u0430\u043f\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0430\u0440\u0445\u0438\u0432. 2014;86(8):80-4 [Mkrtumyan AM, Markova TN, Kichigin VA, et al. The effectiveness of metformin in abdominal obesity. Therapeutic Archive. 2014;86(8):80-4 (In Russ.)]."},{"key":"ref7","unstructured":"\u0414\u0440\u0443\u043a \u0418.\u0412., \u041d\u0435\u0447\u0430\u0435\u0432\u0430 \u0413.\u0418. \u0421\u0430\u0445\u0430\u0440\u043d\u044b\u0439 \u0434\u0438\u0430\u0431\u0435\u0442 2-\u0433\u043e \u0442\u0438\u043f\u0430 \u0434\u043b\u044f \u043a\u0430\u0440\u0434\u0438\u043e\u043b\u043e\u0433\u043e\u0432. \u041f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0440\u0443\u043a\u043e\u0432\u043e\u0434\u0441\u0442\u0432\u043e \u0434\u043b\u044f \u0432\u0440\u0430\u0447\u0435\u0439. \u041c.: \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0435 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u043e\u043d\u043d\u043e\u0435 \u0430\u0433\u0435\u043d\u0442\u0441\u0442\u0432\u043e, 2017 [Druk IV, Nechaeva GI. Type 2 diabetes mellitus for cardiologists: A practical guide for physicians. Moscow: Medicinskoe informacionnoe agentstvo, 2017 (In Russ.)]."},{"key":"ref8","unstructured":"\u0414\u0440\u0430\u043f\u043a\u0438\u043d\u0430 \u041e.\u041c., \u041a\u043e\u0440\u043d\u0435\u0435\u0432\u0430 \u041e.\u041d., \u0418\u0432\u0430\u0448\u043a\u0438\u043d \u0412.\u0422. \u0412\u043b\u0438\u044f\u043d\u0438\u0435 \u043d\u0430 \u043f\u0430\u0440\u0430\u043c\u0435\u0442\u0440\u044b \u0430\u0431\u0434\u043e\u043c\u0438\u043d\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u043e\u0436\u0438\u0440\u0435\u043d\u0438\u044f \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u043e\u043c: \u0444\u043e\u043a\u0443\u0441 \u043d\u0430 \u043f\u0440\u0438\u0432\u0435\u0440\u0436\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u0434\u0438\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u044f\u043c. \u041b\u0435\u0447\u0430\u0449\u0438\u0439 \u0432\u0440\u0430\u0447. 2010;7:29-34 [Drapkina OM, Korneeva ON, Ivashkin VT. Impact on the parameters of abdominal obesity in patients with metabolic syndrome: focus on adherence to dietary recommendations. Lechashchij vrach. 2010;7:29-34 (In Russ.)]."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.17116\/terarkh201688699-104"},{"key":"ref10","unstructured":"\u0411\u0435\u043b\u0435\u043d\u043a\u043e\u0432 \u042e.\u041d., \u0414\u0436\u0435\u0440\u0438\u0435\u0432\u0430 \u0418.\u0421., \u0420\u0430\u043f\u043e\u043f\u043e\u0440\u0442 \u0421.\u0418., \u0412\u043e\u043b\u043a\u043e\u0432\u0430 \u041d.\u0418. \u041c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u043a\u0430\u043a \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442 \u043e\u0431\u0440\u0430\u0437\u0430 \u0436\u0438\u0437\u043d\u0438. \u041c.: \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0435 \u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u043e\u043d\u043d\u043e\u0435 \u0430\u0433\u0435\u043d\u0442\u0441\u0442\u0432\u043e, 2015 [Belenkov YuN, Jerieva IS, Rapoport SI, Volkova NI. Metabolic syndrome as a result of lifestyle. Moscow: Medicinskoe informacionnoe agentstvo, 2015 (In Russ.)]."},{"key":"ref11","unstructured":"\u0422\u044e\u0437\u0438\u043a\u043e\u0432 \u0418.\u0410., \u041a\u0430\u043b\u0438\u043d\u0447\u0435\u043d\u043a\u043e \u0421.\u042e., \u0412\u043e\u0440\u0441\u043b\u043e\u0432 \u041b.\u041e., \u0422\u0438\u0448\u043e\u0432\u0430 \u042e.\u0410. \u0414\u0435\u0444\u0438\u0446\u0438\u0442 \u043c\u0435\u043b\u0430\u0442\u043e\u043d\u0438\u043d\u0430 \u043a\u0430\u043a \u043f\u0440\u0438\u0447\u0438\u043d\u0430 \u0433\u043e\u0440\u043c\u043e\u043d\u0430\u043b\u044c\u043d\u043e-\u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0439 \u0443 \u043c\u0443\u0436\u0447\u0438\u043d. \u0423\u0440\u043e\u043b\u043e\u0433\u0438\u044f \u0438 \u043d\u0435\u0444\u0440\u043e\u043b\u043e\u0433\u0438\u044f. \u0421\u043f\u0435\u0446\u0432\u044b\u043f. \u00ab\u041c\u0443\u0436\u0441\u043a\u043e\u0435 \u0437\u0434\u043e\u0440\u043e\u0432\u044c\u0435\u00bb. \u042d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u0430\u044f \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f. 2015;27:48-55 [Tyuzikov IA, Kalinchenko SYu, Vorslov LO, Tishova YuA. Melatonin Deficiency as a Cause of Hormone-Metabolic Disorders in Men. Urologiya i nefrologiya. Spetsvyp. \u00abMuzhskoe zdorov\u2019e\u00bb. Effektivnaya farmakoterapiya. 2015;27:48-55 (In Russ.)]."},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"\u041a\u043e\u043d\u0435\u043d\u043a\u043e\u0432 \u0412.\u0418., \u041a\u043b\u0438\u043c\u043e\u043d\u0442\u043e\u0432 \u0412.\u0412., \u041c\u0438\u0447\u0443\u0440\u0438\u043d\u0430 \u0421.\u0412. \u0438 \u0434\u0440. \u041c\u0435\u043b\u0430\u0442\u043e\u043d\u0438\u043d \u043f\u0440\u0438 \u0441\u0430\u0445\u0430\u0440\u043d\u043e\u043c \u0434\u0438\u0430\u0431\u0435\u0442\u0435: \u043e\u0442 \u043f\u0430\u0442\u043e\u0444\u0438\u0437\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u043a \u043f\u0435\u0440\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u0430\u043c \u043b\u0435\u0447\u0435\u043d\u0438\u044f. \u0421\u0430\u0445\u0430\u0440\u043d\u044b\u0439 \u0434\u0438\u0430\u0431\u0435\u0442. 2013;2:11-6 [Konenkov VI, Klimontov VV, Michurina SV, et al. Melatonin and diabetes: from pathophysiology to the treatment perspectives. Sakharnyj diabet. 2013;2:11-6 (In Russ.)].","DOI":"10.14341\/2072-0351-3751"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4172\/2155-615"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.18565\/pharmateca.2019.4.50-54"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"ref16","unstructured":"\u0414\u0435\u0434\u043e\u0432 \u0418.\u0418., \u041c\u0435\u043b\u044c\u043d\u0438\u0447\u0435\u043d\u043a\u043e \u0413.\u0410., \u041f\u0438\u0433\u0430\u0440\u043e\u0432\u0430 \u0415.\u0410. \u0438 \u0434\u0440. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u00ab\u0414\u0435\u0444\u0438\u0446\u0438\u0442 \u0432\u0438\u0442\u0430\u043c\u0438\u043d\u0430 D \u0443 \u0432\u0437\u0440\u043e\u0441\u043b\u044b\u0445: \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430, \u043b\u0435\u0447\u0435\u043d\u0438\u0435, \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0430\u00bb, 2015 [Dedov II, Melnichenko GA, Pigarova EA, et al. Clinical recommendations \u00abVitamin D deficiency in adults: diagnosis, treatment, prevention\u00bb, 2015 (In Russ.)]."},{"key":"ref17","unstructured":"\u041a\u043e\u043d\u0441\u0435\u043d\u0441\u0443\u0441 \u0440\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0445 \u044d\u043a\u0441\u043f\u0435\u0440\u0442\u043e\u0432 \u043f\u043e \u043f\u0440\u043e\u0431\u043b\u0435\u043c\u0435 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430 \u0432 \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438: \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435, \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043a\u0440\u0438\u0442\u0435\u0440\u0438\u0438, \u043f\u0435\u0440\u0432\u0438\u0447\u043d\u0430\u044f \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0430 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u0435. \u041f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430. 2010;13(5):27-32 [Consensus of Russian experts on the problem of metabolic syndrome in the Russian Federation: definition, diagnostic criteria, primary prevention and treatment. Profilakticheskaya meditsina. 2010;13(5):27-32 (In Russ.)]."},{"key":"ref18","unstructured":"\u041c\u043e\u043b\u0447\u0430\u043d\u043e\u0432 \u0410.\u042e., \u0418\u0432\u0430\u043d\u043e\u0432\u0441\u043a\u0430\u044f \u041c.\u041b., \u0420\u0430\u043f\u043e\u043f\u043e\u0440\u0442 \u0421.\u0418., \u041c\u043e\u043b\u0447\u0430\u043d\u043e\u0432\u0430 \u0415.\u0421. \u041e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u043c\u0435\u043b\u0430\u0442\u043e\u043d\u0438\u043d\u0430 \u0432 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0436\u0438\u0434\u043a\u043e\u0441\u0442\u044f\u0445. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0438 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u0430\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430. 2011;6:3-7 [Molchanov AYu, Ivanovskaya ML, Rapoport SI, Molchanova ES. The definition of melatonin in biological fluids. Klinicheskaya i laboratornaya diagnostika.2011;6:3-7 (In Russ.)]."},{"key":"ref19","unstructured":"\u0414\u0440\u0443\u043a \u0418.\u0412., \u0420\u044f\u043f\u043e\u043b\u043e\u0432\u0430 \u0415.\u0410. \u041c\u0435\u0442\u0444\u043e\u0440\u043c\u0438\u043d: \u043e\u0431\u043d\u043e\u0432\u043b\u0435\u043d\u043d\u044b\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u0438 \u043f\u043b\u0435\u0439\u043e\u0442\u0440\u043e\u043f\u043d\u044b\u0439 \u043f\u043e\u0442\u0435\u043d\u0446\u0438\u0430\u043b. \u0422\u0435\u0440\u0430\u043f\u0438\u044f. 2016;2:4(8):44-51 [Druk IV, Ryapolova EA. Metformin: updated guidelines and pleiotropic potential. Terapiya. 2016;4(8):44-51 (In Russ.)]."},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.24411\/2304-9529-2017-00050"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0416-8"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"\u0413\u0440\u043e\u043c\u043e\u0432\u0430 \u041e.\u0410., \u0422\u043e\u0440\u0448\u0438\u043d \u0418.\u042e., \u041f\u0440\u043e\u043d\u0438\u043d \u0410.\u0412. \u041e\u0441\u043e\u0431\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u043b\u043e\u0433\u0438\u0438 \u0432\u043e\u0434\u043e\u0440\u0430\u0441\u0442\u0432\u043e\u0440\u0438\u043c\u043e\u0439 \u0444\u043e\u0440\u043c\u044b \u0432\u0438\u0442\u0430\u043c\u0438\u043d\u0430 D \u043d\u0430 \u043e\u0441\u043d\u043e\u0432\u0435 \u043c\u0438\u0446\u0435\u043b\u043b. \u0424\u0430\u0440\u043c\u0430\u0442\u0435\u043a\u0430. 2015;1:38-45 [Gromova OA, Torshin IYu, Pronin AV. Features of pharmacology of water-soluble form of vitamin D on the basis of micelles. Farmateka. 2015;1:38-45 (In Russ.)].","DOI":"10.1097\/01.NURSE.0000460712.06302.19"},{"key":"ref23","unstructured":"\u0420\u0435\u0433\u0438\u0441\u0442\u0440 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u0441\u0440\u0435\u0434\u0441\u0442\u0432 \u0420\u043e\u0441\u0441\u0438\u0438. \u042d\u043d\u0446\u0438\u043a\u043b\u043e\u043f\u0435\u0434\u0438\u044f \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432. (\u042d\u043b\u0435\u043a\u0442\u0440\u043e\u043d\u043d\u0430\u044f \u0432\u0435\u0440\u0441\u0438\u044f) [Register of medicines of Russia. Encyclopedia of drugs. 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