{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:32:41Z","timestamp":1740180761787,"version":"3.37.3"},"reference-count":21,"publisher":"Consilium Medicum","issue":"2","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To study the basic metabolic functions of the liver in patients with non-alcoholic fatty liver disease and to assess the relationship of these disorders with the bacterial overgrowth syndrome.\r\nMaterials and methods. 50 patients with non-alcoholic fatty liver disease at the stage of steatosis were examined. In the verification of the diagnosis, hepatobiliary system ultrasound and FibroMax test data were used. A study was conducted of indicators of lipid, carbohydrate, protein, pigment, mineral metabolism and the exchange of enzymes in the blood. The bacterial overgrowth syndrome was studied by the results of a hydrogen breath test with lactulose using a Lactof\u0430H2 analyzer.\r\nResults. Patients with non-alcoholic fatty liver disease showed a significant increase in total cholesterol (median 5.9 mmol\/l vs 5.0 mmol\/l, p=0.000013), triglycerides (1.35 g\/l vs 0.9 g\/l, p=0.014), glucose (5.65 mmol\/l against 5.1 mmol\/l, p=0.000001) of blood serum compared with the control group. An increase in total protein and a tendency to decrease in albumin, an increase in serum sodium and calcium were detected. In patients with non-alcoholic fatty liver disease there is a significant increase in the markers of cytolysis and cholestasis compared with the control group. The bacterial overgrowth syndrome was detected in 72% of cases, with ileocecal valve function impaired in 50% of patients, gastrointestinal motility slowed down, or colon dysbiosis occurred. A correlation analysis revealed positive relationships between the bacterial overgrowth syndrome on the one hand and glucose (r=0.83, p0.05), total protein (r=0.35, p0.05), calcium (r=0.5, p0.05) on the other hand; negative relationship between the bacterial overgrowth syndrome and albumin (r=-0.8, p0.05). In this case, a positive relationship between the bacterial overgrowth syndrome and the increase in glycemia after glucose loading, that is, absorption in the small intestine, was revealed.\r\nConclusion. The established violations of the metabolic functions of the liver with non-alcoholic fatty liver disease are closely related to the bacterial overgrowth syndrome.<\/jats:p>","DOI":"10.26442\/00403660.2021.02.200622","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T10:17:28Z","timestamp":1617704248000},"page":"169-173","source":"Crossref","is-referenced-by-count":1,"title":["The importance of the bacterial overgrowth syndrome in the development of disorders metabolic functions of the liver in non-alcoholic fatty liver disease"],"prefix":"10.26442","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-2658","authenticated-orcid":false,"given":"Ya. M.","family":"Vakhrushev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-6316","authenticated-orcid":false,"given":"A. P.","family":"Lukashevich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"ref1","unstructured":"\u0410\u0440\u0434\u0430\u0442\u0441\u043a\u0430\u044f \u041c.\u0414., \u0413\u0430\u0440\u0443\u0448\u044c\u044f\u043d \u0413.\u0412., \u041c\u043e\u0439\u0441\u0430\u043a \u0420.\u041f., \u0422\u043e\u043f\u0447\u0438\u0439 \u0422.\u0411. \u0421\u0438\u043d\u0434\u0440\u043e\u043c \u0438\u0437\u0431\u044b\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0440\u043e\u0441\u0442\u0430 \u0432 \u0442\u043e\u043d\u043a\u043e\u0439 \u043a\u0438\u0448\u043a\u0435 \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u043d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u043e\u0439 \u0436\u0438\u0440\u043e\u0432\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u044c\u044e \u043f\u0435\u0447\u0435\u043d\u0438. \u041a\u0440\u0435\u043c\u043b\u0435\u0432\u0441\u043a\u0430\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0432\u0435\u0441\u0442\u043d\u0438\u043a. 2018;4:92-7 [Ardatskaya MD, Garushyan GV, Moysak RP, Topchiy TB. Prevalence of small intestinal bacterial overgrowth syndrome in patients with nonalcoholic fatty liver disease. Kremlevskaya medicina. Klinicheskij vestnik. 2018;4:92-7 (In Russ.)]."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.31146\/1682-8658-ecg-168-8-4-10"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.31146\/1682-8658-ecg-168-8-23-28"},{"key":"ref4","unstructured":"\u0421\u0443\u0447\u043a\u043e\u0432\u0430 \u0415.\u0412. \u0424\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0435 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u0435 \u0433\u0435\u043f\u0430\u0442\u043e\u0431\u0438\u043b\u0438\u0430\u0440\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b \u043f\u0440\u0438 \u0436\u0438\u0440\u043e\u0432\u043e\u043c \u0433\u0435\u043f\u0430\u0442\u043e\u0437\u0435 \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0441 \u0441\u0430\u0445\u0430\u0440\u043d\u044b\u043c \u0434\u0438\u0430\u0431\u0435\u0442\u043e\u043c. \u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u0430\u044f \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2009;8:26-9 [Suchkova EV. The functional state of the hepatobiliary system in non-alcoholic fatty liver disease in patients with diabetes mellitus. Experimental and clinical gastroenterology. 2009;8:26-9 (In Russ.)]."},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"\u0416\u0438\u0440\u043a\u043e\u0432 \u0418.\u0418., \u0413\u043e\u0440\u0434\u0438\u0435\u043d\u043a\u043e \u0410.\u0412., \u0421\u0435\u0440\u0434\u044e\u043a\u043e\u0432 \u0414.\u042e., \u0414\u043e\u0440\u043e\u0445\u043e\u0432 \u0413.\u042e. \u041a\u043b\u044e\u0447\u0435\u0432\u044b\u0435 \u043c\u043e\u043c\u0435\u043d\u0442\u044b \u044d\u0442\u0438\u043e\u043f\u0430\u0442\u043e\u0433\u0435\u043d\u0435\u0437\u0430 \u043d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u043e\u0439 \u0436\u0438\u0440\u043e\u0432\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043f\u0435\u0447\u0435\u043d\u0438. \u0412\u0435\u0441\u0442\u043d\u0438\u043a \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0432\u043e\u0435\u043d\u043d\u043e-\u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0439 \u0430\u043a\u0430\u0434\u0435\u043c\u0438\u0438. 2019;2(66):219-22 [Zhirkov II, Gordienko AV, Serdyukov DYu, Dorokhov GYu. Key points of etiopathogenesis of non-alcoholic fatty liver disease. Vestnik Rossiiskoi voenno-medicinskoi academii. 2019;2(66):219-22 (In Russ.)].","DOI":"10.17816\/brmma25948"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.012369"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2901"},{"key":"ref8","unstructured":"\u041f\u0430\u0440\u0444\u0435\u043d\u043e\u0432 \u0410.\u0418. \u042d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. \u041c.: \u041c\u0418\u0410, 2009 [Parfenov AI. Enterologiya. \u041c.: MIA, 2009 (In Russ.)]."},{"key":"ref9","unstructured":"\u0412\u0430\u0445\u0440\u0443\u0448\u0435\u0432 \u042f.\u041c., \u041b\u044f\u043f\u0438\u043d\u0430 \u041c.\u0412. \u041a\u043b\u0438\u043d\u0438\u043a\u043e-\u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u0430\u044f \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430 \u0442\u043e\u043d\u043a\u043e\u0439 \u043a\u0438\u0448\u043a\u0438 \u043f\u0440\u0438 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0435. \u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u0430\u044f \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2011;9:26-9 [Vakhrushev YaM, Lyapina MV. Clinical and functional characteristics of small intestine in the metabolic syndrome. Experimental and clinical gastroenterology. 2011;9:26-9 (In Russ.)]."},{"key":"ref10","unstructured":"\u0414\u0436\u0443\u043b\u0430\u0439 \u0413.\u0421., \u0429\u0435\u043b\u043e\u0447\u0435\u043d\u043a\u043e\u0432 \u0421.\u0412. \u041c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u0442\u0430 \u0436\u0435\u043b\u0443\u0434\u043e\u0447\u043d\u043e-\u043a\u0438\u0448\u0435\u0447\u043d\u043e\u0433\u043e \u0442\u0440\u0430\u043a\u0442\u0430 \u0432 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0438 \u043d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u043e\u0439 \u0436\u0438\u0440\u043e\u0432\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043f\u0435\u0447\u0435\u043d\u0438 (\u043e\u0431\u0437\u043e\u0440 \u043b\u0438\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u044b). \u0412\u0435\u0440\u0445\u043d\u0435\u0432\u043e\u043b\u0436\u0441\u043a\u0438\u0439 \u043c\u0435\u0434. \u0436\u0443\u0440\u043d. 2015;14(3):36-41 [Dzhulay GS, Schelochenkov SV. Gastrointestinal microbiota in development of non-alcoholic fatty liver disease (literature review). Verhnevolzhskij medicinskij zhurnal. 2015;14(3):36-41 (In Russ.)]."},{"key":"ref11","unstructured":"\u0424\u0438\u043b\u0430\u0442\u043e\u0432\u0430 \u0418.\u0410., \u041a\u043e\u0437\u043b\u043e\u0432\u0430 \u041d.\u041c., \u0422\u0438\u0440\u0438\u043a\u043e\u0432\u0430 \u041e.\u0412. \u0438 \u0434\u0440. \u0420\u043e\u043b\u044c \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430 \u0438\u0437\u0431\u044b\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0440\u043e\u0441\u0442\u0430 \u0432 \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u0435\u0437\u0435 \u043d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u043e\u0439 \u0436\u0438\u0440\u043e\u0432\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043f\u0435\u0447\u0435\u043d\u0438. \u0414\u043d\u0435\u0432\u043d\u0438\u043a \u041a\u0430\u0437\u0430\u043d\u0441\u043a\u043e\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u043e\u0439 \u0448\u043a\u043e\u043b\u044b. 2018;4(22):104-8 [Filatova IA, Kozlova NM, Tiricova OV, et al. The role of small intestinal bacterial overgrowth syndrome in the pathogenesis of non-alcoholic fatty liver disease. Dnevnik Kazanskoj medicinskoj shkoly. 2018;4(22):104-8 (In Russ.)]."},{"key":"ref12","unstructured":"\u041c\u0430\u0442\u0430\u043b\u044b\u0433\u0438\u043d\u0430 \u041e.\u0410. \u041f\u0438\u0442\u0430\u043d\u0438\u0435 \u2013 \u043a\u0438\u0448\u0435\u0447\u043d\u0430\u044f \u043c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u0442\u0430 \u2013 \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f. \u041d\u043e\u0432\u043e\u0435 \u0438\u0437\u043c\u0435\u0440\u0435\u043d\u0438\u0435. \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430: \u0442\u0435\u043e\u0440\u0438\u044f \u0438 \u043f\u0440\u0430\u043a\u0442\u0438\u043a\u0430. 2019;4(1):271-6 [Matalygina OA. Nutrition \u2013 intestinal microbiota \u2013 cardiovascular diseases. A new dimensionnull. Medicine: theory and practice. 2019;4(1):271-6 (In Russ.)]."},{"key":"ref13","unstructured":"\u041a\u043e\u0437\u043b\u043e\u0432\u0430 \u0418.\u0412., \u041b\u0430\u043f\u0442\u0435\u0432\u0430 \u0415.\u0410., \u041b\u0435\u043a\u0430\u0440\u0435\u0432\u0430 \u041b.\u0418. \u041d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u0430\u044f \u0436\u0438\u0440\u043e\u0432\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a: \u0432\u0437\u0430\u0438\u043c\u043e\u0441\u0432\u044f\u0437\u0438 \u0438 \u0432\u0437\u0430\u0438\u043c\u043e\u0432\u043b\u0438\u044f\u043d\u0438\u044f. \u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u0430\u044f \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2017;138(2):86-91 [Kozlova IV, Lapteva EA, Lekareva LI. Nonalcoholic fatty liver disease and colon: the relationship and interaction. Experimental and clinical gastroenterology. 2017;138(2):86-91 (In Russ.)]."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1061\/j.cmet.2013.01.003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms.3384"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1358520"},{"key":"ref17","unstructured":"\u041b\u0430\u0437\u0435\u0431\u043d\u0438\u043a \u041b.\u0411., \u0417\u0432\u0435\u043d\u0438\u0433\u043e\u0440\u043e\u0434\u0441\u043a\u0430\u044f \u041b.\u0410. \u041c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0438 \u043e\u0440\u0433\u0430\u043d\u044b \u043f\u0438\u0449\u0435\u0432\u0430\u0440\u0435\u043d\u0438\u044f. \u041c.: \u0410\u043d\u0430\u0445\u0430\u0440\u0441\u0438\u0441, 2009 [Lazebnik LB, Zvenigorodskaya LA. Metabolicheskiy sindrom i organy pishchevareniya. Moscow: Anaharsis, 2009 (In Russ.)]."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.22416\/1382-4376-2018-28-4-84-90"},{"key":"ref19","unstructured":"\u0424\u0435\u0434\u043e\u0441\u044c\u0438\u043d\u0430 \u0415.\u0410., \u0416\u0430\u0440\u043a\u043e\u0432\u0430 \u041c.\u0421., \u041c\u0430\u0435\u0432\u0441\u043a\u0430\u044f \u041c.\u0412. \u0411\u0430\u043a\u0442\u0435\u0440\u0438\u0430\u043b\u044c\u043d\u0430\u044f \u043a\u0438\u0448\u0435\u0447\u043d\u0430\u044f \u043c\u0438\u043a\u0440\u043e\u0444\u043b\u043e\u0440\u0430 \u0438 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u043f\u0435\u0447\u0435\u043d\u0438. \u0420\u043e\u0441. \u0436\u0443\u0440\u043d. \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0438, \u0433\u0435\u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043a\u043e\u043b\u043e\u043f\u0440\u043e\u043a\u0442\u043e\u043b\u043e\u0433\u0438\u0438. 2009;19(6):73-81 [Fedosyina YeA, Zharkova MS, Maevskaya MV. Bacterial intestinal microflora and diseases of the liver. Rus J Gastroenterol Hepatol Coloproctol. 2009;19(6):73-81 (In Russ.)]."},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.20514\/2226-6704-2019-9-1-64-69"},{"key":"ref21","unstructured":"\u041f\u043b\u043e\u0442\u043d\u0438\u043a\u043e\u0432\u0430 \u0415.\u042e. \u041d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u0430\u044f \u0436\u0438\u0440\u043e\u0432\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u043c\u0438\u043a\u0440\u043e\u0444\u043b\u043e\u0440\u0430 \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0430. \u0413\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f \u0421\u0430\u043d\u043a\u0442-\u041f\u0435\u0442\u0435\u0440\u0431\u0443\u0440\u0433\u0430. 2017;2:76-85 [Plotnikova EYu. Non-alcoholic fatty liver disease and intestinal microflora. Gastroenterologiya Sankt-Peterburga. 2017;2:76-85 (In Russ.)]."}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/64710\/47586","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/64710\/47586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T20:04:22Z","timestamp":1634155462000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/64710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,15]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,15]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2021.02.200622","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"type":"electronic","value":"2309-5342"},{"type":"print","value":"0040-3660"}],"subject":[],"published":{"date-parts":[[2021,2,15]]}}}