{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:32:18Z","timestamp":1774344738850,"version":"3.50.1"},"reference-count":18,"publisher":"Consilium Medicum","issue":"5","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To assess the diagnostic value of the detection of soluble transferrin receptors (sTfR) and ferritin index (sTfR\/log Fer) in patients with spondyloarthritis (SpA) and anemia for the revealing absolute iron deficiency (ID).\r\nMaterials and methods. The study included 68 patients with SpA: median age  39 [34; 47] years, men: 38 (55.9%). Hemogram, C-reactive protein levels and ferrokinetics parameters were assessed, including sTfR testing by the method of quantitative enzyme-linked immunosorbent assay (Monobind Inc., USA). We also calculated sTfR\/log Fer. Based on ferrokinetics parameters and C-reactive protein levels, chronic disease anemia (CDA), iron deficiency anemia (IDA), or their combination (CDA\/IDA) were diagnosed.\r\nResults. CDA was diagnosed in 16 patients, CDA\/IDA  in 32 patients, and 20 patients had no anemia. An increase in sTfR concentration in patients with CDA\/IDA (1.7 [1.4; 2.2] mg\/L) compared with patients with CDA (1.5 [1.1; 1.7] mg\/L, p0.05) was revealed. sTfR\/log Fer in patients with CDA\/IDA (0.93 [0.82; 1.24]) was higher than in patients with CDA (0.64 [0.48; 0.75], p0.0001). When evaluating the ROC curves, it was found that sTfR levels 1.39 mg\/L and sTfR\/log Fer levels 0.83 indicate the presence of absolute ID. The area under the ROC curve for sTfR was 0.72 (95% confidence interval 0.600.82, p0.001), for sTfR\/log Fer  0.85 (95% confidence interval 0.740.92, p0.001). The sensitivity and specificity of sTfR\/log Fer (75 and 83%, respectively) were higher compared with sTfR (53 and 81%, respectively).\r\nConclusion. In patients with SpA having CDA\/IDA, sTfR and sTfR\/log Fer are statistically significantly increased. The results obtained indicate the possibility of diagnosing ID by using these parameters.<\/jats:p>","DOI":"10.26442\/00403660.2021.05.200870","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T11:53:21Z","timestamp":1624449201000},"source":"Crossref","is-referenced-by-count":2,"title":["Soluble transferrin receptors and ferritin index in the diagnosis of iron deficiency in patients with spondyloarthritis and anemia"],"prefix":"10.26442","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8989-8405","authenticated-orcid":false,"given":"Karina N.","family":"Safarova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1765-2737","authenticated-orcid":false,"given":"Kseniia D.","family":"Dorogoykina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3563-5535","authenticated-orcid":false,"given":"Eduard A.","family":"Fedotov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3463-7734","authenticated-orcid":false,"given":"Andrey P.","family":"Rebrov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.183"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.17116\/terarkh2016885107\u2013112"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210770"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133645"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22108"},{"key":"ref7","unstructured":"WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System. Geneva, World Health Organization, 2011. (WHO\/NMH\/NHD\/MNM\/11.1). Available at: http:\/\/www.who.int\/vmnis\/indicators\/haemoglobin.pdf. Accessed: 18.10.2019."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13773"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Wilson A, Yu HT, Goodnough LT, Nissenson AR. Prevalence and outcomes of anemia in rheumatoid arthritis: a systematic review of the literature. Am J Med. 2004;116(Suppl. 7A):50S-57S. DOI:10.1016 \/ j.amjmed.2003.12.012","DOI":"10.1016\/j.amjmed.2003.12.012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202709"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket233"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Niccoli L, Nannini C, Cassar\u00e0 E, et al. Frequency of anemia of inflammation in patients with ankylosing spondylitis requiring anti-TNF\u03b1 drugs and therapy-induced changes. Int J Rheum Dis. 2012;15(1):56-61. DOI:10.1111 \/ j.1756-185X.2011.01662","DOI":"10.1111\/j.1756-185X.2011.01662.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.18786\/2072-0505-2019-47-037"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.14412\/1996-7012-2018-1-13-19"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.36740\/WLek202004117"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.14412\/1995-4484-2015-299-307"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.17650\/1818-836-2016-11-1-37-46"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2018.11.012"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/71514\/52269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/71514\/52269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T19:48:27Z","timestamp":1634154507000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/71514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,15]]},"references-count":18,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,15]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2021.05.200870","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5,15]]}}}