{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T09:57:18Z","timestamp":1763978238482,"version":"3.37.3"},"reference-count":36,"publisher":"Consilium Medicum","issue":"8","license":[{"start":{"date-parts":[[2021,8,15]],"date-time":"2021-08-15T00:00:00Z","timestamp":1628985600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. Evaluation of the practice of using trimebutine (tablets, 300 mg, extended release), for the treatment of patients with functional gastrointestinal disorders (FGID) in primary health care.\r\nMaterials and methods. A prospective observational multicenter non-interventional study was carried out, which included patients of both sexes aged 18 to 60 years with a verified diagnosis of functional gastrointestinal disorders (functional dyspepsia, irritable bowel syndrome, biliary tract dysfunction, sphincter of Oddi dysfunction, postcholecystectomy syndrome). Trimebutine was prescribed in accordance with the instructions for medical use: orally, 300 mg twice per day for 28 days. The severity of simptoms was evaluated by five-point rating scale.\r\nResults. The study included 4433 patients, the per protocol sample consisted of 3831 people. The proportion of patients with a significant decrease in the severity of abdominal pain after treatment was 74.73% (95% confidence interval  CI 73.3276.11). At the and of the study a statistically significant decrease in the severity of FGID` simptoms was observed: epigastric pain\/burning (mean score at the 1st visit was 1.21 [95% CI 1.181.25], at the 2nd visit  0.22 [95% CI 0.20.23]; p0.001), abdominal pain (1st visit  2.01 [95% CI 1.982.04), 2nd visit  0.33 [95% CI 0.310.35]; p0.001), biliary pain (1st visit  1.22 [95% CI 1.181.26], 2nd visit  0.2 [95% CI 0.190.22]; p0.001), postprandial fullness and early satiation (1st visit  1.29 [95% CI 1.251.32], 2nd visit  0.21 [95% CI 0.190.22]; p0.001), severity of heartburn (1st visit  0.92 [95% CI 0.880.95], 2nd visit  0.18 [95% CI 0.170.20]; p0.001), belching (1st visit  1.13 [95% CI 1.091.16], 2nd visit  0.22 [95% CI 0.210.24]; p0.001), as well as abdominal distention (1st visit  1.99 (95% CI 1, 96, 2.03), 2nd visit  0.43 [95% CI 0.410.45]; p0.001).\r\nConclusion. The present prospective observational multicenter non-interventional study has demonstrated that trimebutine is an effective approach to treating FGID.<\/jats:p>","DOI":"10.26442\/00403660.2021.08.200919","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:37:07Z","timestamp":1631101027000},"page":"897-903","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of trimebutine in the treatment of functional gastrointestinal disorders: an observational multicenter study"],"prefix":"10.26442","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4007-7112","authenticated-orcid":false,"given":"Dmitry N.","family":"Andreev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6114-564X","authenticated-orcid":false,"given":"Igor V.","family":"Maev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2021,8,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.22416\/1382-4376-2017-27-1-4-11"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.032"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14165"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Lewis ML, Palsson OS, Whitehead WE, van Tilburg MA. 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Pharmacological properties of trimebutine and M-monodesmethyltrimebutine. J Pharmacol Exp Ther. 1999;289(3):1391-7. 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Efficacy of drugs most commonly prescribed at functional gastrointestinal diseases (functional dyspepsia syndrome and irritable bowel syndrome) observational study results. 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Assessment of the role of inflammatory and microbiological changes in irritable bowel syndrome in children. Abstract of thesis. dis. ... Cand. honey. sciences. Saint Petersburg, 2014 (in Russian)]."},{"key":"ref32","unstructured":"\u0413\u0440\u0438\u043d\u0435\u0432\u0438\u0447 \u0412.\u0411., \u0421\u0430\u0441 \u0415.\u0418., \u041a\u0440\u0430\u0432\u0447\u0443\u043a \u042e.\u0410., \u0438 \u0434\u0440. \u0411\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u044c \u0434\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0433\u043e \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u044f \u0441\u0435\u043b\u0435\u043a\u0442\u0438\u0432\u043d\u044b\u0445 \u041c3-\u0445\u043e\u043b\u0438\u043d\u043e\u043b\u0438\u0442\u0438\u043a\u043e\u0432 \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0441 \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u043e\u043c \u0440\u0430\u0437\u0434\u0440\u0430\u0436\u0435\u043d\u043d\u043e\u0439 \u043a\u0438\u0448\u043a\u0438. \u0420\u041c\u0416. 2014;22(15):1103-7 [Grinevich VB, Sas EI, Kravchuk YA, et al. Safety of long-term use of selective M3 anticholinergics in patients with irritable bowel syndrome. Breast cancer. 2014;22(15):1103-7 (in Russian)]."},{"key":"ref33","unstructured":"\u042f\u043a\u043e\u0432\u0435\u043d\u043a\u043e \u042d.\u041f., \u0410\u0433\u0430\u0444\u043e\u043d\u043e\u0432\u0430 \u041d.\u0410., \u042f\u043a\u043e\u0432\u0435\u043d\u043a\u043e \u0410.\u0412., \u0438 \u0434\u0440. \u0410\u0433\u043e\u043d\u0438\u0441\u0442 \u043e\u043f\u0438\u0430\u0442\u043d\u044b\u0445 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u0432 \u0442\u0440\u0438\u043c\u0435\u0431\u0443\u0442\u0438\u043d \u0432 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0445 \u0440\u0430\u0441\u0441\u0442\u0440\u043e\u0439\u0441\u0442\u0432 \u0436\u0435\u043b\u0447\u043d\u043e\u0433\u043e \u043f\u0443\u0437\u044b\u0440\u044f \u0438 \u0441\u0444\u0438\u043d\u043a\u0442\u0435\u0440\u0430 \u041e\u0434\u0434\u0438. \u041b\u0435\u0447\u0430\u0449\u0438\u0439 \u0432\u0440\u0430\u0447. 2014;2:56 [Yakovenko EP, Agafonova NA, Yakovenko AV, et al. Opiate receptor agonist trimebutin in the treatment of functional disorders of the gallbladder and the sphincter of Oddi. Attending doctor. 2014;2:56 (in Russian)]."},{"key":"ref34","unstructured":"\u0418\u0432\u0430\u0448\u043a\u0438\u043d \u0412.\u0422., \u0428\u0435\u043b\u044b\u0433\u0438\u043d \u042e.\u0410., \u0411\u0430\u0440\u0430\u043d\u0441\u043a\u0430\u044f \u0415.\u041a., \u0438 \u0434\u0440. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0430\u0441\u0441\u043e\u0446\u0438\u0430\u0446\u0438\u0438 \u0438 \u0410\u0441\u0441\u043e\u0446\u0438\u0430\u0446\u0438\u0438 \u043a\u043e\u043b\u043e\u043f\u0440\u043e\u043a\u0442\u043e\u043b\u043e\u0433\u043e\u0432 \u0420\u043e\u0441\u0441\u0438\u0438 \u043f\u043e \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044e \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430 \u0440\u0430\u0437\u0434\u0440\u0430\u0436\u0435\u043d\u043d\u043e\u0433\u043e \u043a\u0438\u0448\u0435\u0447\u043d\u0438\u043a\u0430. \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0438, \u0433\u0435\u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043a\u043e\u043b\u043e\u043f\u0440\u043e\u043a\u0442\u043e\u043b\u043e\u0433\u0438\u0438. 2017;27(5):76-93 [Ivashkin VT, Shelygin YuA, Baranskaya YK, et al. Diagnosis and treatment of the irritable bowel syndrome: clinical guidelines of the Russian gastroenterological association and Russian association of coloproctology. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2017;27(5):76-93 (in Russian)]."},{"key":"ref35","unstructured":"\u0418\u0432\u0430\u0448\u043a\u0438\u043d \u0412.\u0422., \u041c\u0430\u0435\u0432 \u0418.\u0412., \u0428\u0435\u043f\u0442\u0443\u043b\u0438\u043d \u0410.\u0410., \u0438 \u0434\u0440. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0430\u0441\u0441\u043e\u0446\u0438\u0430\u0446\u0438\u0438 \u043f\u043e \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044e \u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0439 \u0434\u0438\u0441\u043f\u0435\u043f\u0441\u0438\u0438. \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0438, \u0433\u0435\u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043a\u043e\u043b\u043e\u043f\u0440\u043e\u043a\u0442\u043e\u043b\u043e\u0433\u0438\u0438. 2017;1:50-61 [Ivashkin VT, Mayev IV, Sheptulin AA, et al. Diagnosis and treatment of the functional dyspepsia: clinical guidelines of the Russian Gastroenterological Association. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2017;27(1):50-61 (in Russian)]."},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.22416\/1382-4376-2018-28-3-63-80"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/79425\/60070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/79425\/60070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T04:22:58Z","timestamp":1634098978000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/79425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,15]]},"references-count":36,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,15]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2021.08.200919","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"type":"electronic","value":"2309-5342"},{"type":"print","value":"0040-3660"}],"subject":[],"published":{"date-parts":[[2021,8,15]]}}}