{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:34:28Z","timestamp":1740180868494,"version":"3.37.3"},"reference-count":36,"publisher":"Consilium Medicum","issue":"10","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Background. The main factors that increase the risk of cardiovascular accidents and mortality among patients with COVID-19 include hyperglycemia, arterial hypertension and dyslipidemia. Therefore, all patients with COVID-19 and metabolic syndrome should receive antihypertensive (AHT), hypolipidemic (GLT) and hypoglycemic therapy (GGT). Currently, there is a limited number of studies regarding the effectiveness and safety of this therapy in patients with COVID-19.\r\nAim. Evaluate the clinical outcomes of patients with COVID-19, depending on the recipient of AHT, GLT and GGT.\r\nMaterials and methods. A retrospective analysis of the clinical outcomes \"discharged\/died\" of 1753 patients with COVID-19 was carried out depending on the received AHT, GLT and GGT.\r\nResults. A significant reduction in the risk of mortality among patients with COVID-19 was observed during therapy with angiotensin-converting enzyme inhibitors\/angiotensin II receptor blockers  ACE inhibitors\/ARBs (OR 0.39, 95% CI 0.210.72; p0.05) and b-adrenergic blockers  b-AB (OR 0.53, 95% CI 0.281; p0.05). At the same time, against the background of therapy with ACE inhibitors\/ARBs and b-ABs, the chance of mortality decreased more significantly among patients with type 2 diabetes mellitus (T2DM) compared with patients without T2DM. Diuretic therapy was associated with a 3-fold increase in the chances of death: OR 3.33, 95% CI 1.884.79; p0.05. Statin therapy did not affect clinical outcomes in COVID-19 patients. On the background of therapy with oral hypoglycemic drugs, the risk of mortality decreased 5-fold (OR 0.19, 95% CI 0.070.54; p0.05). Against the background of insulin therapy, there was an increase in mortality risk by 2.8 times (OR 2.81, 95% CI 1.55.29; p0.05).\r\nConclusion. A significant reduction in mortality among patients with COVID-19 was observed during therapy with ACEI\/ARB, b-AB, and oral hypoglycemic therapy. Increased risk of death was associated with insulin therapy and diuretic therapy.<\/jats:p>","DOI":"10.26442\/00403660.2021.10.201072","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T18:35:47Z","timestamp":1636137347000},"page":"1193-1202","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective analysis of clinical outcomes of patients with COVID-19 depending on receiving antihypertensive, lipid-lowering and antihypertensive therapy"],"prefix":"10.26442","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6385-540X","authenticated-orcid":false,"given":"Tatiana Yu.","family":"Demidova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3656-0312","authenticated-orcid":false,"given":"Kristina G.","family":"Lobanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6276-2305","authenticated-orcid":false,"given":"Sergey N.","family":"Perekhodov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9944-2997","authenticated-orcid":false,"given":"Michail B.","family":"Antsiferov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9856-8643","authenticated-orcid":false,"given":"Olga S.","family":"Oynotkinova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"ref1","unstructured":"\u0410\u0432\u0434\u0435\u0435\u0432 \u0421.\u041d., \u0410\u0434\u0430\u043c\u044f\u043d \u041b.\u0412., \u0410\u043b\u0435\u043a\u0441\u0435\u0435\u0432\u0430 \u0415.\u0418., \u0438 \u0434\u0440. \u0412\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u043c\u0435\u0442\u043e\u0434\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438. \u041f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0430, \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u043d\u043e\u0432\u043e\u0439 \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0439 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438 (COVID-19). \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u043e \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0424\u0435\u0434\u0435\u0440\u0430\u0446\u0438\u0438. \u0412\u0435\u0440\u0441\u0438\u044f 7. 03.06.2020 [Avdeev SN, Adamyan LV, Alekseeva EI, et al. 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