{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:12:26Z","timestamp":1777349546573,"version":"3.51.4"},"reference-count":30,"publisher":"Consilium Medicum","issue":"10","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To compare advanced glycation end-products (AGE, RAGE) and 3-nitrotyrosine (3-HT) in patients with DM 1 after successful simultaneous pancreas-kidney transplantation (SPK) and kidney transplantation alone (KTA). To assess relationship between levels of AGE, RAGE, 3-HT and renal transplant (RT) function, carbohydrate and mineral metabolism.\r\nMaterials and methods. The study included 58 patients who received kidney transplantation in end-stage renal disease (ESRD). 36 patients received SPK. There were performed routine laboratory, examination of AGE, RAGE, 3-NT, parathyroid hormone (PTH), 25(OH)vitamin D, calcium, phosphorus, FGF23, osteoprotegerin (OPG), and fetuin-A levels.\r\nResults. All patients after SPK reached normoglycemia (HbA1c 5.7 [5.3; 6.1] %; C-peptide 3.24 [2.29; 4.40] ng\/ml) with the achievement of significant difference vs patients after KTA. Arterial hypertension (AH) was more frequent in recipients of SPK before transplantation than after (p=0.008). AH also persisted in greater number of cases in patients after KTA than after SPK. Patients after SPK had higher AGE (\u0440=0.0003) and lower RAGE (\u0440=0.000003) levels. OPG in patients after SPK was significantly higher (\u0440=0.04). The correlation analysis revealed significant positive correlation between 3-HT and OPG (p0.05; r=0.30), RAGE and eGFR (r=-0.52), HbA1c (r=0.48), duration of AH (r=0.34), AGE with HbA1c (r=0.51).\r\nConclusion. The results of the \"metabolic memory\" markers analysis may indicate their contribution to the persistence of the metabolic consequences of CKD and DM 1 after achievement of normoglycemia and renal function restoration and their possible participation in development of recurrent nephropathy, vascular calcification, and bone disorders.<\/jats:p>","DOI":"10.26442\/00403660.2021.10.201100","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T18:35:47Z","timestamp":1636137347000},"page":"1155-1163","source":"Crossref","is-referenced-by-count":1,"title":["Advanced glycation end products and oxidative stress as a basis for metabolic abnormalities in patients with type 1 diabetes after successful simultaneous pancreas-kidney transplantation"],"prefix":"10.26442","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6783-4200","authenticated-orcid":false,"given":"Irina I.","family":"Larina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0296-4933","authenticated-orcid":false,"given":"Anastasia S.","family":"Severina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0067-3622","authenticated-orcid":false,"given":"Irina S.","family":"Maganeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina R.","family":"Ainetdinova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-062X","authenticated-orcid":false,"given":"Anna K.","family":"Eremkina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8148-8180","authenticated-orcid":false,"given":"Alina O.","family":"Gavrilova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3433-0142","authenticated-orcid":false,"given":"Minara S.","family":"Shamhalova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5731-3310","authenticated-orcid":false,"given":"Ilya V.","family":"Dmitriev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9019-9567","authenticated-orcid":false,"given":"Aleksey V.","family":"Pinchuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-127X","authenticated-orcid":false,"given":"Marina V.","family":"Shestakova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1029"},{"key":"ref2","unstructured":"Bahar SG, Devulapally P. Pancreas Transplantation. 2020. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2021."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.15825\/1995-1191-2020-2-8-34"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.23873\/2074-0506-2009-0-1-19-31"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.14341\/DM2015269-78"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807093390202"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03627.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2015.00067"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.01.050"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8120638"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.15825\/1995-1191-2017-1-111-121"},{"key":"ref12","unstructured":"Jenssen TG, Lindahl JPH, Reinholdt F, et al. Simultaneous kidney and pancreas transplantation, compared to hyperglycaemia, improves longterm (>8 yrs) outcome in the transplanted kidney. Diabetologia Clinical and Experimental. Diabetologia. 2011;54:2417-20."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02414.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200301150-00012"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191421"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3353-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.10.006"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.11.034"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2000.7738"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1177\/1358863x06072202"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2189582"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-009-0439-2"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-015-0292-2"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0925"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2010.02298.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-012-0279-2"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1824"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2004.03.002"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.24884\/1561-6274-2017-21-4-30-39"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00211"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/86666\/65043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/86666\/65043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T11:19:41Z","timestamp":1643023181000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/86666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,15]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10,15]]}},"URL":"https:\/\/doi.org\/10.26442\/00403660.2021.10.201100","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10,15]]}}}