{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:10:22Z","timestamp":1780405822768,"version":"3.54.1"},"reference-count":31,"publisher":"Consilium Medicum","issue":"11","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To study the relationship of hemostatic disorders with inflammation and estimate their role in the course and outcomes of COVID-19.\r\nMaterials and methods. We examined 215 consecutive patients with moderate and severe forms of acute COVID-19. The patients were on anticoagulants and immunosuppressive drugs. Hemostasis was assessed using the thrombodynamics assay, thromboelastography, fibrinogen and D-dimer levels, prothrombin time, and soluble fibrin-monomer complexes (ethanol gelation test). The hemostatic parameters were correlated with hematological and biochemical tests, including markers of inflammation (C-reactive protein, interleukins 6 and 8), as well as with the disease severity and outcomes.\r\nResults. Laboratory signs of coagulopathy were revealed in the vast majority of the cases. Despite the use of low-molecular-weight heparins in the prophylactic and therapeutic doses, coagulopathy in COVID-19 manifested predominantly as hypercoagulability that correlated directly with the systemic inflammation and metabolic changes due to liver and kidney dysfunction. A direct relationship was found between the grade of coagulopathy and the severity of COVID-19, including comorbidities and the mortality. The chronometric hypocoagulability observed in about 1\/4 cases was associated with a high level of C-reactive protein, which may decelerate coagulation in vitro and thereby mask the true inflammatory thrombophilia. Persistent hyperfibrinogenemia and high D-dimer in the absence of consumption coagulopathy suggest the predominance of local and\/or regional microthrombosis over disseminated intravascular coagulation.\r\nConclusion. The results obtained substantiate the need for laboratory monitoring of hemostasis and active prophylaxis and treatment of thrombotic complications in COVID-19.<\/jats:p>","DOI":"10.26442\/00403660.2021.11.201185","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T09:54:04Z","timestamp":1643795644000},"page":"1255-1263","source":"Crossref","is-referenced-by-count":1,"title":["Peculiarities of blood coagulation disorders in patients with COVID-19"],"prefix":"10.26442","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4950-3691","authenticated-orcid":false,"given":"Natalia G.","family":"Evtugina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0668-1877","authenticated-orcid":false,"given":"Svetlana S.","family":"Sannikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8790-1818","authenticated-orcid":false,"given":"Alina D.","family":"Peshkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4657-0140","authenticated-orcid":false,"given":"Svetlana I.","family":"Safiullina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3973-3183","authenticated-orcid":false,"given":"Izabella A.","family":"Andrianova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3599-1599","authenticated-orcid":false,"given":"Gulzada R.","family":"Tarasova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-8832","authenticated-orcid":false,"given":"Alina I.","family":"Khabirova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1643-5960","authenticated-orcid":false,"given":"Aleksandr G.","family":"Rumyantsev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6668-0948","authenticated-orcid":false,"given":"Fazoil I.","family":"Ataullakhanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-1496","authenticated-orcid":false,"given":"Rustem I.","family":"Litvinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18344","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000508233"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.21518\/1995-1477-2020-3-4-36-51"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.18087\/cardio.2020.5.n1132"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.15829\/1728-8800-2020-2571"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.05.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14810"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.17816\/KMJ2020-485"},{"key":"ref8","unstructured":"\u0412\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u043c\u0435\u0442\u043e\u0434\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438. \u041f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0430, \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u043d\u043e\u0432\u043e\u0439 \u043a\u043e\u0440\u043e\u043d\u0430\u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0439 \u0438\u043d\u0444\u0435\u043a\u0446\u0438\u0438 (COVID-19). \u041c\u0438\u043d\u0438\u0441\u0442\u0435\u0440\u0441\u0442\u0432\u043e \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044f \u0420\u0424. \u0412\u0435\u0440\u0441\u0438\u044f 9 (26.10.2020). \u0420\u0435\u0436\u0438\u043c \u0434\u043e\u0441\u0442\u0443\u043f\u0430: https:\/\/static-0.minzdrav.gov.ru\/system\/attachments\/attaches\/000\/052\/548\/original\/%D0%9C%D0%A0_COVID-19_%28v.9%29.pdf?1603730062. \u0421\u0441\u044b\u043b\u043a\u0430 \u0430\u043a\u0442\u0438\u0432\u043d\u0430 \u043d\u0430 18.11.2020 [Temporary guidelines. 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